Dr. Mircea Mujat Profile

Dr. Mircea Mujat

Principal Research Scientist at Physical Sciences Inc

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Author

Publications (28)

Proceedings Article | 13 March 2024 Presentation

Multispectral cellular-level imaging of Aβ in the retina

Mircea Mujat, Ankit Patel, John Grimble, Nicusor Iftimia

Proceedings Volume PC12824, PC128240E (2024) https://doi.org/10.1117/12.3005686

KEYWORDS: Multispectral imaging, Retina, Retinal scanning, In vivo imaging, Alzheimer's disease, Spatial resolution, Retinal diseases, Nervous system, Image resolution, Eye models

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Proceedings Article | 13 March 2024 Presentation + Paper

High-resolution retinal phase gradient imaging using line-scanning laser ophthalmoscopy

Ankit Patel, Nicusor Iftimia, Taeyoon Son, Tobiloba Adejumo, Xincheng Yao, Mircea Mujat

Proceedings Volume 12824, 1282403 (2024) https://doi.org/10.1117/12.3005629

KEYWORDS: Scanning laser ophthalmoscopy, Confocal microscopy, Adaptive optics, Retina, Retinal scanning, Cameras, Light sources and illumination, Visualization, Phase imaging, Eye

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Proceedings Article | 17 March 2023 Presentation

Phase imaging of retinal microstructures with multi-channel AOSLO

Mircea Mujat, Ankit Patel, Nicusor Iftimia

Proceedings Volume PC12360, PC123600W (2023) https://doi.org/10.1117/12.2650877

KEYWORDS: Phase imaging, Visualization, Retinal scanning, Optical fibers, Eye, Wavefronts, Scattering, Retina, Microscopy, Image resolution

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Proceedings Article | 6 March 2023 Presentation

Guiding skin cancer therapy with combined confocal-OCT imaging

Nicusor Iftimia, Gopi Maguluri, John Grimble, Mircea Mujat, Aliana Caron, Aditi Sahu, Miguel Cordova, Milind Rajadhyaksha, Christopher Barker

Proceedings Volume PC12368, PC1236807 (2023) https://doi.org/10.1117/12.2649339

KEYWORDS: Skin cancer, Optical coherence tomography, Image resolution, Skin, Tissue optics, Reflectivity, Radiotherapy, Radio optics, Diagnostics, Confocal microscopy

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Proceedings Article | 5 March 2021 Presentation + Paper

Choroidal and retinal hemodynamic imager

Mircea Mujat, Ankit Patel, Gopi Maguluri, R. Daniel Ferguson, Nicusor Iftimia

Proceedings Volume 11623, 116230G (2021) https://doi.org/10.1117/12.2583310

KEYWORDS: Optical coherence tomography, Hemodynamics, Imaging systems, Blood circulation, Visualization, Doppler tomography, Veins, Sensors, Retina, Ophthalmic imaging

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Proceedings Article | 5 March 2021 Presentation + Paper

Simultaneous multi-offset imaging of retinal microstructures free of directionality artifacts

Mircea Mujat, Ankit Patel, Gopi Maguluri, R. Daniel Ferguson, Nicusor Iftimia

Proceedings Volume 11623, 116230E (2021) https://doi.org/10.1117/12.2583298

KEYWORDS: Retinal scanning, Optical fibers, Imaging systems, Scanning laser ophthalmoscopy, Scanning laser ophthalmoscopes, Light scattering, Detector development, Capillaries, Blood vessels, Blood

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Proceedings Article | 26 April 2016 Presentation

OCT-based profiler for automating ocular surface prosthetic fitting (Conference Presentation)

Mircea Mujat, Ankit Patel, Gopi Maguluri, Nicusor Iftimia, Chirag Patel, Josh Agranat, Olga Tomashevskaya, Eugene Bonte, R. Daniel Ferguson

Proceedings Volume 9693, 96930Z (2016) https://doi.org/10.1117/12.2213938

KEYWORDS: Optical coherence tomography, Sclera, Cornea, Eye, 3D metrology, Physical sciences, Contact lenses, Holmium, Current controlled current source

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Proceedings Article | 11 March 2015 Paper

High-resolution retinal imaging: enhancement techniques

Mircea Mujat, Ankit Patel, Nicusor Iftimia, James Akula, Anne Fulton, R. Daniel Ferguson

Proceedings Volume 9307, 930703 (2015) https://doi.org/10.1117/12.2082711

KEYWORDS: Image registration, Imaging systems, Linear filtering, Sensors, Retinal scanning, Digital imaging, Detection and tracking algorithms, Channel projecting optics, Convolution, Matrices

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Proceedings Article | 3 March 2014 Paper

Compact adaptive optics line scanning retinal imager; closer to the clinic

Mircea Mujat, Ankit Patel, Nicusor Iftimia, R. Daniel Ferguson

Proceedings Volume 8930, 89301B (2014) https://doi.org/10.1117/12.2040261

KEYWORDS: Adaptive optics, Imaging systems, Optical coherence tomography, Confocal microscopy, Scanning laser ophthalmoscopy, Cones, Image resolution, Eye, Head, Retinal scanning

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Proceedings Article | 27 September 2013 Paper

Mueller matrix microscopy

Mircea Mujat, R. Daniel Ferguson, Nicusor Iftimia

Proceedings Volume 8873, 88730E (2013) https://doi.org/10.1117/12.2024962

KEYWORDS: Polarization, Microscopes, Optical components, Wave plates, Polarizers, Polarimetry, Microscopy, Refractive index, Birefringence, Dichroic materials

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Proceedings Article | 16 February 2011 Paper

Advanced capabilities of the multimodal adaptive optics imager

Daniel Hammer, R. Ferguson, Mircea Mujat, David Biss, Nicusor Iftimia, Ankit Patel, Emily Plumb, Melanie Campbell, Jennifer Norris, Alfredo Dubra, Toco Chui, James Akula, Anne Fulton

Proceedings Volume 7885, 78850A (2011) https://doi.org/10.1117/12.876579

KEYWORDS: Optical coherence tomography, Scanning laser ophthalmoscopy, Adaptive optics, Imaging systems, Raster graphics, Video, Multichannel imaging systems, Image registration, Scanners, Doppler effect

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Proceedings Article | 16 February 2011 Paper

Towards real-time wavefront sensorless adaptive optics using a graphical processing unit (GPU) in a line scanning system

David Biss, Ankit Patel, R. Daniel Ferguson, Mircea Mujat, Nicusor Iftimia, Daniel Hammer

Proceedings Volume 7885, 788516 (2011) https://doi.org/10.1117/12.876645

KEYWORDS: Adaptive optics, Sensors, Mirrors, Wavefronts, Imaging systems, Image sensors, Wavefront sensors, Eye, Graphics processing units, Eye models

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Proceedings Article | 3 March 2010 Paper

Multimodal adaptive optics for depth-enhanced high-resolution ophthalmic imaging

Daniel Hammer, Mircea Mujat, Nicusor Iftimia, Niyom Lue, R. Daniel Ferguson

Proceedings Volume 7550, 755011 (2010) https://doi.org/10.1117/12.846583

KEYWORDS: Adaptive optics, Optical coherence tomography, Scanning laser ophthalmoscopy, Imaging systems, Eye, Eye models, Point spread functions, Retina, Human subjects, Algorithm development

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We developed a multimodal adaptive optics (AO) retinal imager for diagnosis of retinal diseases, including glaucoma, diabetic retinopathy (DR), age-related macular degeneration (AMD), and retinitis pigmentosa (RP). The development represents the first ever high performance AO system constructed that combines AO-corrected scanning laser ophthalmoscopy (SLO) and swept source Fourier domain optical coherence tomography (SSOCT) imaging modes in a single compact clinical prototype platform. The SSOCT channel operates at a wavelength of 1 μm for increased penetration and visualization of the choriocapillaris and choroid, sites of major disease activity for DR and wet AMD. The system is designed to operate on a broad clinical population with a dual deformable mirror (DM) configuration that allows simultaneous low- and high-order aberration correction. The system also includes a wide field line scanning ophthalmoscope (LSO) for initial screening, target identification, and global orientation; an integrated retinal tracker (RT) to stabilize the SLO, OCT, and LSO imaging fields in the presence of rotational eye motion; and a high-resolution LCD-based fixation target for presentation to the subject of stimuli and other visual cues. The system was tested in a limited number of human subjects without retinal disease for performance optimization and validation. The system was able to resolve and quantify cone photoreceptors across the macula to within ~0.5 deg (~100-150 μm) of the fovea, image and delineate ten retinal layers, and penetrate to resolve targets deep into the choroid. In addition to instrument hardware development, analysis algorithms were developed for efficient information extraction from clinical imaging sessions, with functionality including automated image registration, photoreceptor counting, strip and montage stitching, and segmentation. The system provides clinicians and researchers with high-resolution, high performance adaptive optics imaging to help guide therapies, develop new drugs, and improve patient outcomes.

SPIE Journal Paper | 1 May 2009 Open Access

Automated algorithm for breast tissue differentiation in optical coherence tomography

Mircea Mujat, Robert Ferguson, Daniel Hammer, Christopher Gittins, Nicusor Iftimia

JBO, Vol. 14, Issue 03, 034040, (May 2009) https://doi.org/10.1117/12.10.1117/1.3156821

KEYWORDS: Tissues, Optical coherence tomography, Tissue optics, Tumors, Biopsy, Breast, Reflectivity, Diagnostics, Coherence imaging, Image processing

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SPIE Journal Paper | 1 March 2009 Open Access

Three-dimensional pointwise comparison of human retinal optical property at 845 and 1060 nm using optical frequency domain imaging

Yueli Chen, Daina Burnes, Martijn de Bruin, Mircea Mujat, Johannes de Boer

JBO, Vol. 14, Issue 02, 024016, (March 2009) https://doi.org/10.1117/12.10.1117/1.3119103

KEYWORDS: Optical coherence tomography, Scattering, Optical properties, Retina, Image segmentation, 3D image processing, Retinal scanning, Optical imaging, Absorption, Signal attenuation

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Proceedings Article | 20 February 2009 Paper

Swept-source parallel OCT

Mircea Mujat, Nicusor Iftimia, R. Daniel Ferguson, Daniel Hammer

Proceedings Volume 7168, 71681E (2009) https://doi.org/10.1117/12.809915

KEYWORDS: Optical coherence tomography, Sensors, Image processing, Mirrors, Tissues, Charge-coupled devices, Cameras, Reflectivity, Spectroscopy, Data acquisition

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Proceedings Article | 18 February 2009 Paper

Multimodal scanning laser ophthalmoscopy for image guided treatment of age-related macular degeneration

Daniel Hammer, R. Ferguson, Ankit Patel, Nicusor Iftimia, Mircea Mujat, Deeba Husain

Proceedings Volume 7163, 71631C (2009) https://doi.org/10.1117/12.810050

KEYWORDS: Photodynamic therapy, Angiography, Imaging systems, Eye, Electronics, Confocal microscopy, Scanning laser ophthalmoscopy, Sensors, Head, Video

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Proceedings Article | 18 February 2009 Paper

Compact adaptive optics line scanning laser ophthalmoscope

Daniel Hammer, Mircea Mujat, Nicusor Iftimia, R. Ferguson

Proceedings Volume 7163, 71630J (2009) https://doi.org/10.1117/12.810445

KEYWORDS: Adaptive optics, Cones, Imaging systems, Sensors, Wavefronts, Mirrors, Eye, Retina, Scanning laser ophthalmoscopes, Capillaries

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SPIE Journal Paper | 1 July 2007 Open Access

Autocalibration of spectral-domain optical coherence tomography spectrometers for in vivo quantitative retinal nerve fiber layer birefringence determination

Mircea Mujat, Boris Park, Barry Cense, Teresa Chen, Johannes de Boer

JBO, Vol. 12, Issue 04, 041205, (July 2007) https://doi.org/10.1117/12.10.1117/1.2764460

KEYWORDS: Polarization, Birefringence, Optical coherence tomography, Spectrometers, Calibration, Modulation, In vivo imaging, Retina, Nerve, Biomedical optics

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Proceedings Article | 7 February 2007 Paper

In-vivo human retinal imaging with pulsed illumination spectral-domain optical coherence tomography

Jang-Woo You, Teresa Chen, Mircea Mujat, B. Hyle Park, Johannes de Boer

Proceedings Volume 6429, 642912 (2007) https://doi.org/10.1117/12.701240

KEYWORDS: Signal to noise ratio, Retinal scanning, Retina, In vivo imaging, Optical coherence tomography, Motion measurement, Cameras, Standards development, Eye

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Proceedings Article | 7 March 2006 Paper

Retinal nerve fiber layer thickness map

Mircea Mujat, Raymond Chan, Barry Cense, Hyle Park, Chulmin Joo, Teresa Chen, Johannes de Boer

Proceedings Volume 6138, 61380J (2006) https://doi.org/10.1117/12.649064

KEYWORDS: Optical coherence tomography, Reflectivity, Nerve, Image processing, Blood vessels, Binary data, Retina, Tissue optics, Edge detection, Biomedical optics

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Proceedings Article | 20 February 2006 Paper

Retinal nerve fiber layer thickness map and blood flow pulsation measured with SDOCT

Mircea Mujat, Raymond Chan, Barry Cense, Mark Pierce, Hyle Park, Chulmin Joo, Teresa Chen, Johannes de Boer

Proceedings Volume 6079, 607909 (2006) https://doi.org/10.1117/12.649095

KEYWORDS: Optical coherence tomography, Blood circulation, Reflectivity, Blood vessels, Nerve, Arteries, Veins, Doppler effect, Doppler tomography, Phase shifts

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Proceedings Article | 13 April 2005 Paper

Spectral-domain polarization-sensitive optical coherence tomography at 850 nm

Barry Cense, Teresa Chen, Mircea Mujat, Chulmin Joo, Taner Akkin, B. Park, Mark Pierce, Andy Yun, Brett Bouma, Guillermo Tearney, Johannes de Boer

Proceedings Volume 5690, (2005) https://doi.org/10.1117/12.592840

KEYWORDS: Optical coherence tomography, Polarization, Retina, Nerve, Phase measurement, Eye, Birefringence, Line scan cameras, Beam splitters, Lamps

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Proceedings Article | 13 April 2005 Paper

Fluid flow analysis in microfluidic devices by spectral-domain optical Doppler tomography

Mark Pierce, Chulmin Joo, Barry Cense, Eli Weinberg, B. Hyle Park, Mircea Mujat, Jeffrey Borenstein, Guillermo Tearney, Brett Bouma, Johannes de Boer

Proceedings Volume 5690, (2005) https://doi.org/10.1117/12.592864

KEYWORDS: Microfluidics, Doppler tomography, Optical coherence tomography, Fluid dynamics, Capillaries, Velocity measurements, Microfluidic imaging, Phase measurement, Imaging devices, Imaging systems

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Proceedings Article | 1 April 2005 Paper

Fluid flow analysis in microfluidic devices by spectral-domain optical Doppler tomography

Mark Pierce, Chulmin Joo, Barry Cense, Eli Weinberg, Boris Hyle Park, Mircea Mujat, Jeffrey Borenstein, Guillermo Tearney, Brett Bouma, Johannes de Boer

Proceedings Volume 5692, (2005) https://doi.org/10.1117/12.589862

KEYWORDS: Microfluidics, Doppler tomography, Optical coherence tomography, Microfluidic imaging, Capillaries, Fluid dynamics, Velocity measurements, Velocimetry, Imaging devices, Particles

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Proceedings Article | 12 December 2003 Paper

Polarimetric signature of dense scattering media

Mircea Mujat, Alexander Spier, Aristide Dogariu

Proceedings Volume 5158, (2003) https://doi.org/10.1117/12.506109

KEYWORDS: Particles, Scattering, Light scattering, Polarization, Specular reflections, Silica, Scattering media, Backscatter, Polarimetry, Remote sensing

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Proceedings Article | 5 September 2000 Paper

Real-time Mueller matrix measurement for particulate systems

Mircea Mujat, Aristide Dogariu

Proceedings Volume 4035, (2000) https://doi.org/10.1117/12.397810

KEYWORDS: Polarization, Scattering, Particles, Atmospheric propagation, Multiple scattering, Light scattering, Silica, Absorbance, Denoising, Photons

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Proceedings Article | 23 August 1996 Paper

Measurement of parasite Doppler effect in radar systems using laser heterodyning techniques

Nicusor Iftimia, Mircea Mujat, Virgil Vasiliu, Ileana Iftimia

Proceedings Volume 2868, (1996) https://doi.org/10.1117/12.248658

KEYWORDS: Heterodyning, Doppler effect, Radar, Laser systems engineering, Helium neon lasers, Distance measurement, Antennas, Signal processing, Sensors, Space telescopes

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Showing 5 of 28 publications

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