Mr. Nathaniel J. M. Haven Profile

Nathaniel J. M. Haven

at Univ of Alberta

SPIE Involvement:

Author

Publications (29)

Proceedings Article | 13 March 2024 Presentation

Deep ultraviolet transmittance and scattering microscopy for virtual histology

Brendyn Cikaluk, Mohammad Masoumi, Brendon Restall, Matthew Martell, Nathaniel J. Haven, Roger Zemp

Proceedings Volume PC12854, PC128540P (2024) https://doi.org/10.1117/12.3001806

KEYWORDS: Microscopy, Deep ultraviolet, Confocal fluorescent microscopy, Tissues, Scattering, Ultraviolet radiation, Imaging systems, UV optics, Transmittance, Tissue optics

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Proceedings Article | 13 March 2024 Presentation

Combined ultraviolet confocal reflectance, autofluorescence, and photoacoustic remote sensing microscopy for generating virtual sectioned histology in thick tissues

Nathaniel J. Haven, Brendon Restall, Matthew Martell, Brendyn Cikaluk, Roger Zemp

Proceedings Volume PC12842, PC128421K (2024) https://doi.org/10.1117/12.3002864

KEYWORDS: Tissues, Confocal microscopy, Ultraviolet radiation, Reflectivity, Autofluorescence, Remote sensing, Photoacoustic spectroscopy, Resection, Surgery, Microscopy

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Proceedings Article | 13 March 2024 Presentation

Photoacoustic remote sensing microscopy and meta-LASE microscopy for visualizing virtual histology, circulating tumor cells, and tissue energetics

Pradyumna Kedarisetti, Nathaniel J. Haven, Matthew Martell, Frank Wuest, Roger Zemp

Proceedings Volume PC12854, PC128540I (2024) https://doi.org/10.1117/12.3002145

KEYWORDS: Biological imaging, White blood cells, Tumors, Remote sensing, Photoacoustic spectroscopy, Photoacoustic imaging, Diagnostics, Blood, Cancer detection, Biological samples

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Proceedings Article | 13 March 2024 Presentation

Comparing deep ultraviolet transmission microscopy and ultraviolet photoacoustic remote sensing microscopy for thin-tissue histology

Brendyn Cikaluk, Mohammad Masoumi, Nathaniel J. Haven, Matthew Martell, Brendon Restall, Roger Zemp

Proceedings Volume PC12842, PC128421N (2024) https://doi.org/10.1117/12.3002868

KEYWORDS: Microscopy, Ultraviolet radiation, Transmittance, Tissues, Remote sensing, Photoacoustic spectroscopy, Diagnostics, Deep ultraviolet, Target detection, Photoacoustic imaging

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Proceedings Article | 11 August 2023 Paper

Ultraviolet photoacoustic remote sensing and scattering microscopy for CycleGAN-enabled realistic virtual histology

Matthew Martell, Nathaniel J. Haven, Ewan McAlister, Brendon Restall, Brendyn Cikaluk, Rohan Mittal, Benjamin Adam, Nadia Giannakopoulos, Lashan Peiris, Sveta Silverman, Jean Deschenes, Xingyu Li, Roger Zemp

Proceedings Volume 12631, 126310C (2023) https://doi.org/10.1117/12.2671022

KEYWORDS: Tissues, Ultraviolet radiation, Scattering, Remote sensing, Photoacoustic spectroscopy, Microscopy, Breast, Surgery, Gold, Diagnostics

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Proceedings Article | 11 August 2023 Paper

Utilizing a ten million frames-per-second camera to investigate mechanisms responsible for laser pulse-induced reflectivity modulations in photoacoustic remote sensing

Nathaniel J. Haven, Matthew Martell, Haoyang Li, James Hogan, Roger Zemp

Proceedings Volume 12631, 1263103 (2023) https://doi.org/10.1117/12.2670970

KEYWORDS: Modulation, Remote sensing, Photoacoustic spectroscopy, Cameras, Water, Gold, Photoacoustic imaging, Microscopy, Refractive index, Contrast agents

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Proceedings Article | 16 March 2023 Presentation

Prostate needle biopsy metabolic analysis and virtual H&E microscopy using photoacoustic remote sensing and autofluorescence microscopy (Conference Presentation)

Brendon Restall, Brendyn Cikaluk, Matthew Martell, Nathaniel J. Haven, Adam Kinnaird, Roger Zemp

Proceedings Volume PC12391, PC123910P (2023) https://doi.org/10.1117/12.2650688

KEYWORDS: Microscopy, Remote sensing, Photoacoustic spectroscopy, Biopsy, Prostate, Biological research, Genomics, Cancer, Prostate cancer, Image quality

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Proceedings Article | 9 March 2023 Presentation

Combined ultraviolet confocal reflectance and photoacoustic remote sensing microscopy for generating virtual sectioned histology

Nathaniel J. Haven, Matthew Martell, Jean Deschenes, Lashan Peiris, Nadia Giannakopoulos, Roger Zemp

Proceedings Volume PC12379, PC123791T (2023) https://doi.org/10.1117/12.2650881

KEYWORDS: Confocal microscopy, Ultraviolet radiation, Microscopy, Reflectivity, Remote sensing, Photoacoustic spectroscopy, Tissue optics, Absorption, Tissues, Objectives

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Proceedings Article | 9 March 2023 Presentation

Rapid virtual histology of fresh tissue via photoacoustic remote sensing microscopy and a voice-coil scanning stage

Brendyn Cikaluk, Brendon Restall, Matthew Martell, Nathaniel J. Haven, Roger Zemp

Proceedings Volume PC12379, PC123791V (2023) https://doi.org/10.1117/12.2649205

KEYWORDS: Remote sensing, Photoacoustic spectroscopy, Microscopy, Tissue optics, Ultraviolet radiation, Imaging systems, UV optics, Tumors, Tissues, Scattering

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Proceedings Article | 9 March 2023 Presentation

Photoacoustic remote sensing combined with autofluorescence surface excitation for virtual histology and metabolism imaging

Brendon Restall, Brendyn Cikaluk, Matthew Martell, Nathaniel J. Haven, Roger Zemp

Proceedings Volume PC12379, PC123791Q (2023) https://doi.org/10.1117/12.2649338

KEYWORDS: Remote sensing, Photoacoustic spectroscopy, Cancer, Mode conditioning cables, Tumors, Solids, Receptors, Optical testing, Molecules, Absorption

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Proceedings Article | 9 March 2023 Presentation

Multimodal imaging with ultraviolet photoacoustic remote sensing and interferometric synthetic aperture microscopy

Matthew Martell, Nathaniel J. Haven, Brendon Restall, Roger Zemp

Proceedings Volume PC12367, PC123670V (2023) https://doi.org/10.1117/12.2651039

KEYWORDS: Ultraviolet radiation, Synthetic aperture microscopy, Remote sensing, Photoacoustic spectroscopy, Interferometry, Tissues, Multimodal imaging, UV optics, Scattering, Optical coherence tomography

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Proceedings Article | 7 March 2022 Presentation

Towards high-speed widefield ultraviolet photoacoustic remote sensing microscopy via voice-coil stage scanning and an on-demand pulsed laser

Brendyn Cikaluk, Brendon Restall, Nathaniel J. Haven, Matthew Martell, Roger Zemp

Proceedings Volume PC11960, PC119602M (2022) https://doi.org/10.1117/12.2610286

KEYWORDS: Ultraviolet radiation, Pulsed laser operation, Remote sensing, Photoacoustic spectroscopy, Tissues, Absorption, Surgery, Scattering, Reflectivity, Modulation

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Proceedings Article | 7 March 2022 Presentation

Virtual hematoxylin and eosin histopathology with ultraviolet photoacoustic remote sensing and synthetic aperture optical coherence microscopy

Matthew Martell, Nathaniel J. Haven, Brendon Restall, Sveta Silverman, Lashan Peiris, Jean Deschenes, Roger Zemp

Proceedings Volume PC11960, PC1196006 (2022) https://doi.org/10.1117/12.2610470

KEYWORDS: Ultraviolet radiation, Remote sensing, Photoacoustic spectroscopy, Optical coherence tomography, Optical coherence microscopy, Microscopy, Image resolution, Tissue optics, Scattering, UV optics

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Proceedings Article | 7 March 2022 Presentation

Ultraviolet scattering and photoacoustic remote sensing (sPARS) microscopy for virtual H&E histology

Nathaniel J. Haven, Matthew Martell, Brendyn Cikaluk, Brendon Restall, Ewan McAlister, Roger Zemp, Sveta Silverman, Lashan Peiris, Jean Deschenes, Xingyu Li

Proceedings Volume PC11960, PC1196005 (2022) https://doi.org/10.1117/12.2610317

KEYWORDS: Ultraviolet radiation, Scattering, Remote sensing, Photoacoustic spectroscopy, Microscopy, Laser scattering, Gold, Standards development, Image resolution, Tumors

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Proceedings Article | 7 March 2022 Presentation

Towards high-speed camera-based parallelized widefield photoacoustic remote sensing microscopy

Nathaniel J. Haven, Matthew Martell, Haoyang Li, James Hogan, Roger Zemp, Brendon Restall

Proceedings Volume PC11960, PC119602C (2022) https://doi.org/10.1117/12.2610350

KEYWORDS: Cameras, Microscopy, Remote sensing, Photoacoustic spectroscopy, High speed cameras, Modulation, Image resolution, Fiber optic illuminators, Wavefronts, Reflectivity

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Proceedings Article | 7 March 2022 Presentation

Rapid virtual H&E photoacoustic remote sensing using constant velocity and galvanometer mirror scanning

Brendon Restall, Brendyn Cikaluk, Nathaniel J. Haven, Matthew Martell, Sveta Silverman, Lashan Peiris, Jean Deschenes, Roger Zemp

Proceedings Volume PC11960, PC1196024 (2022) https://doi.org/10.1117/12.2610322

KEYWORDS: Remote sensing, Photoacoustic spectroscopy, Mirrors, Tissues, Ultraviolet radiation, Tissue optics, Surgery, Prostate, Optical microscopy, Microscopy

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Proceedings Article | 7 March 2022 Poster + Presentation

OCT-guided contour scanning for dynamically-focused photoacoustic remote sensing microscopy

Matthew Martell, Nathaniel J. Haven, Sveta Silverman, Lashan Peiris, Jean Deschenes, Roger Zemp

Proceedings Volume PC11960, PC119601K (2022) https://doi.org/10.1117/12.2610457

KEYWORDS: Microscopy, Remote sensing, Photoacoustic spectroscopy, Tissues, Natural surfaces, Surgery, Scattering, Optical coherence tomography, Breast, Ultraviolet radiation

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Proceedings Article | 7 March 2022 Presentation

Improving the histological realism of ultraviolet photoacoustic remote sensing microscopy images using a deep learning-based generative adversarial network

Matthew Martell, Ewan McAlister, Nathaniel J. Haven, Sveta Silverman, Lashan Peiris, Jean Deschenes, Xingyu Li, Roger Zemp

Proceedings Volume PC11960, PC1196013 (2022) https://doi.org/10.1117/12.2610461

KEYWORDS: Microscopy, Ultraviolet radiation, Remote sensing, Photoacoustic spectroscopy, Oncology, Cancer, Visualization, Tissues, Solids, Scattering

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Proceedings Article | 9 December 2021 Paper

Virtual histological assessment of human breast tumor specimens using spectral-domain optical coherence tomography augmented with ultraviolet photoacoustic remote sensing microscopy

Matthew Martell, Nathaniel J. Haven, Brendon Restall, Pradyumna Kedarisetti, Lashan Peiris, Sveta Silverman, Jean Deschenes, Roger Zemp

Proceedings Volume 11923, 1192312 (2021) https://doi.org/10.1117/12.2615989

KEYWORDS: Tissues, Optical coherence tomography, Tumors, Ultraviolet radiation, Tissue optics, Breast, Scattering, Microscopy, Remote sensing, Photoacoustic spectroscopy

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Proceedings Article | 7 December 2021 Paper

Depth-resolved hematoxylin and eosin virtual histopathology with photoacoustic remote sensing and scattering microscopy

Brendon Restall, Nathaniel J. Haven, Matthew Martell, Pradyumna Kedarisetti, Brendyn Cikaluk, Sveta Silverman, Lashan Peiris, Jean Deschenes, Roger Zemp

Proceedings Volume 11922, 119220S (2021) https://doi.org/10.1117/12.2615728

KEYWORDS: Tissues, Scattering, Microscopy, Surgery, Remote sensing, Photoacoustic spectroscopy, Imaging systems, Breast, Absorption, Lung

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Proceedings Article | 7 December 2021 Paper

Fast analysis of resected breast tissue margins using ultraviolet photoacoustic remote sensing microscopy

Brendyn Cikaluk, Matthew Martell, Nathaniel J. Haven, Brendon Restall, Roger Zemp

Proceedings Volume 11922, 1192219 (2021) https://doi.org/10.1117/12.2615795

KEYWORDS: Tissues, Tissue optics, Microscopy, Photoacoustic spectroscopy, Ultraviolet radiation, Remote sensing, Breast, Surgery, Tumors, Breast cancer

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SPIE Journal Paper | 15 September 2021 Open Access

Multimodal 3D photoacoustic remote sensing and confocal fluorescence microscopy imaging

Brendon S. Restall, Pradyumna Kedarisetti, Nathaniel J. Haven, Matthew Martell, Roger Zemp

JBO, Vol. 26, Issue 09, 096501, (September 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.9.096501

KEYWORDS: Luminescence, Tissues, Confocal microscopy, Imaging systems, Microscopy, Absorption, Photoacoustic spectroscopy, 3D image processing, Remote sensing, 3D photoacoustic microscopy

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SPIE Journal Paper | 23 June 2021 Open Access

Fiber-based photoacoustic remote sensing microscopy and spectral-domain optical coherence tomography with a dual-function 1050-nm interrogation source

Matthew Martell, Nathaniel J. Haven, Roger Zemp

JBO, Vol. 26, Issue 06, 066502, (June 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.6.066502

KEYWORDS: Optical coherence tomography, Imaging systems, Microscopy, Light sources, Mirrors, Photoacoustic spectroscopy, Remote sensing, Absorption, Integrated optics, Photodiodes

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Significance: Spectral-domain optical coherence tomography (SD-OCT) offers depth-resolved imaging of optical scattering contrast but is limited in sensitivity to optical absorption. Dual-modality imaging combined with the noncontact absorption contrast of photoacoustic remote sensing (PARS) microscopy can augment SD-OCT applications with specific molecular and functional contrasts in an all-optical, fiber-based platform. Aim: To develop a fiber-based multimodal PARS and SD-OCT imaging system, which efficiently uses a common 1050-nm light source for SD-OCT and PARS interrogation. Approach: PARS microscopy has predominantly utilized a 1310-nm interrogation light source to date. Hence, a recent dual-modality PARS and 1050-nm SD-OCT imaging system required three distinct wavelengths including a 532-nm PARS excitation, necessitating a free-space optical architecture with discrete subsystems. Here, we validate the first use of a 1050-nm interrogation wavelength for PARS. This enables the transition to fiber-based interferometry as is standard in modern SD-OCT systems, though infeasible with inclusion of an additional 1310-nm wavelength. PARS interrogation functionality is integrated using a broadband optical circulator. Results: Dual-modality imaging is demonstrated in carbon fiber phantoms and a mouse ear in vivo. SD-OCT provided a 4.5-μm lateral resolution, 8.8-μm axial resolution in air, and >101 dB of sensitivity, and PARS contributed 532-nm optical absorption contrast with a 47-dB SNR, and lateral and axial resolutions of 2.4 and 35 μm, respectively. Total interrogation power was reduced from 90% to 58% of the ANSI limit compared to a previous three-wavelength approach. Conclusions: Adapting PARS to use the 1050-nm SD-OCT light source for interrogation enabled implementation of a fiber-based dual-modality system configuration, with image quality maintained. This will facilitate development of potential applications demanding handheld, catheter-based, or endoscopic form factors.

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Proceedings Article | 5 March 2021 Presentation

Towards non-contact functional oxygen metabolism estimation with multi-wavelength photoacoustic remote sensing and Doppler optical coherence tomography

Matthew Martell, Nathaniel J. Haven, Pradyumna Kedarisetti, Roger Zemp, Brendon Restall

Proceedings Volume 11642, 1164233 (2021) https://doi.org/10.1117/12.2578942

KEYWORDS: Optical coherence tomography, Oxygen, Remote sensing, Photoacoustic spectroscopy, Doppler tomography, Mode conditioning cables, In vivo imaging, Image resolution, Structural imaging, Tissues

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Proceedings Article | 5 March 2021 Presentation

Comprehensive evaluation of ex vivo and in vivo tissues with ultraviolet photoacoustic remote sensing virtual histology and spectral-domain optical coherence tomography

Matthew Martell, Nathaniel J. Haven, Brendon Restall, Pradyumna Kedarisetti, Roger Zemp

Proceedings Volume 11642, 116422W (2021) https://doi.org/10.1117/12.2578954

KEYWORDS: Tissues, Optical coherence tomography, In vivo imaging, Ultraviolet radiation, Remote sensing, Photoacoustic spectroscopy, Tumors, Tissue optics, Natural surfaces, UV optics

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Proceedings Article | 5 March 2021 Presentation

Photoacoustic remote sensing 3D H&E histology with fluorescence validation

Brendon Restall, Nathaniel J. Haven, Matthew Martell, Pradyumna Kedarisetti, Brendyn Cikaluk, Lashan Peiris, Sveta Silverman, Jean Deschenes, Roger Zemp

Proceedings Volume 11642, 1164231 (2021) https://doi.org/10.1117/12.2578944

KEYWORDS: Remote sensing, Photoacoustic spectroscopy, Tissues, UV optics, Tissue optics, Refractive index, Reflectivity, Confocal microscopy, Luminescence, Microscopy

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Proceedings Article | 5 March 2021 Presentation

Label-free virtual H&E histopathology using f-mode ultraviolet photoacoustic remote sensing

Pradyumna Kedarisetti, Nathaniel J. Haven, Brendon Restall, Matthew Martell, Roger Zemp

Proceedings Volume 11642, 116422S (2021) https://doi.org/10.1117/12.2578545

KEYWORDS: Photoacoustic spectroscopy, Ultraviolet radiation, Remote sensing, Image restoration, Scattering, Principal component analysis, Photoacoustic microscopy, Microscopy, Electronic filtering

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Proceedings Article | 17 February 2020 Paper

Multispectral photoacoustic remote sensing microscopy using 532nm and 266nm excitation wavelengths

Brendon Restall, Nathaniel Haven, Pradyumna Kedarisetti, Roger Zemp

Proceedings Volume 11240, 112404C (2020) https://doi.org/10.1117/12.2546410

KEYWORDS: Microscopy, In vivo imaging, Signal to noise ratio, Photoacoustic spectroscopy, Absorption, Ultraviolet radiation, Tissue optics, Image resolution, Remote sensing

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Proceedings Article | 4 March 2019 Presentation

Label-free non-contact imaging of cell nuclei using ultraviolet photoacoustic remote sensing microscopy (Conference Presentation)

Nathaniel J. Haven, Kevan Bell, Pradyumna Kedarisetti, Parsin Haji Reza, John Lewis, Roger Zemp

Proceedings Volume 10878, 108781X (2019) https://doi.org/10.1117/12.2508036

KEYWORDS: Microscopy, Ultraviolet radiation, Photoacoustic spectroscopy, Remote sensing, Surgery, Cancer, Confocal microscopy, Tumors, Gold, UV optics

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Showing 5 of 29 publications

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