Mr. Nigel R. Sharma Profile

Nigel R. Sharma

at MicroPlumbers Microsciences LLC

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Proceedings Article | 13 February 2008 Paper

Development of an evaporation-based microfluidic sample concentrator

Nigel Sharma, Anatoly Lukyanov, Ron Bardell, Lynn Seifried, Mingchao Shen

Proceedings Volume 6886, 68860R (2008) https://doi.org/10.1117/12.764100

KEYWORDS: Solar concentrators, Liquids, Microfluidics, Particles, Humidity, Proteins, Control systems, Bacteria, Sensors, Diffusion

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MicroPlumbers Microsciences LLC, has developed a relatively simple concentrator device based on isothermal evaporation. The device allows for rapid concentration of dissolved or dispersed substances or microorganisms (e.g. bacteria, viruses, proteins, toxins, enzymes, antibodies, etc.) under conditions gentle enough to preserve their specific activity or viability. It is capable of removing of 0.8 ml of water per minute at 37°C, and has dimensions compatible with typical microfluidic devices. The concentrator can be used as a stand-alone device or integrated into various processes and analytical instruments, substantially increasing their sensitivity while decreasing processing time. The evaporative concentrator can find applications in many areas such as biothreat detection, environmental monitoring, forensic medicine, pathogen analysis, and agricultural industrial monitoring. In our presentation, we describe the design, fabrication, and testing of the concentrator. We discuss multiphysics simulations of the heat and mass transport in the device that we used to select the design of the concentrator and the protocol of performance testing. We present the results of experiments evaluating water removal performance.

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