The fourth industrial revolution will change the way we create, apply, and inspect Smart Materials and Systems. Modern manufacturing techniques are characterized by networking of systems in all industrial areas (Industry 4.0) and producing individual components tailored to the needs of individual customers. This course explains how the Internet of Things and the next generation of industrial production encompasses the complete networking of all industrial areas. New production techniques, such as 3D printing, will allow efficient in-time production for low numbers of unique parts. A significant aspect is also quality and maintainability of these sometimes unique structures and components. NDE has to follow these trends, by not only adapting NDE techniques to the new technologies, but also by introducing the capability of cyber systems into the inspection and maintenance processes. This course will introduce present trends in industry such as production of individual parts by 3D printing, product design and testing by digital twins, 3D volume data creation, component live data files, management of big data, real time monitoring of structural integrity, reliable inspection of individual components, and remote NDE to include competencies not available onsite.