Photodynamic diagnosis and therapy (PDD and PDT) involve the use of photochemical reactions induced by light irradiation with a photosensitizer for the detection and treatment of cancer cells and tissues. 5-Aminolevukinic acid (5-ALA) is a clinically used drug for PDT (5-ALA-PDT) in glioblastoma and bladder cancer. However, the conventional 5-ALA-PDT using visible light sours is not effective for the deep portion of organs and tissues. In this study, to overcome the limitation in penetration depth of 5-ALA-PDT, we developed two-photon excited 5-ALA-PDT system with NIR fiber laser for the effective treatment of peritoneal dissemination in gastric cancer.
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