Dr. Osman O. Ahsen
at Massachusetts General Hospital
SPIE Involvement:
Area of Expertise:
Optical coherence tomography , Intravascular imaging , Esophageal cancer and dysplasia , Endoscopic imaging , Fluorescence imaging , Nonlinear microscopy
Profile Summary

I have done my graduate research in the research group that pioneered the development of Optical Coherence Tomography (OCT) imaging technology. During my tenure at the MIT, I have made contributions to several OCT and fluorescence imaging technologies including swept source-OCT, Optical Coherence Microscopy and Nonlinear Imaging Microscopy. These imaging devices were developed in a highly collaborative setting involving clinical collaborators at the VA Boston Healthcare System and Beth Israel Deaconess Medical Center, as well as our industrial partners at the Thorlabs, Inc and Praevium Research, Inc. I got the opportunity to work on throughout the various stages of medical device development pipeline, which involved development of basic technology, demonstrating its safety and effectiveness in preclinical settings, obtaining regulatory approvals for in human testing and finally conducting large-scale human studies to assess clinical utility. Recently, I joined Dr. Guillermo J. Tearney’s group at Wellman Center at the MGH, and have shifted my focus to intravascular imaging. In Dr. Tearney’s group I am working on developing novel multi-modal intravascular imaging technologies aimed to improve clinical management of coronary artery disease, by combining an array of technologies such as OCT, near-infrared fluorescence and near-infrared autofluorescence (NIRAF) imaging, and endothelial shear stress measurement methods.
Publications (5)

Proceedings Article | 7 March 2019 Presentation
Proc. SPIE. 10855, Diagnostic and Therapeutic Applications of Light in Cardiology 2019
KEYWORDS: Coherence (optics), Visualization, Image segmentation, Image processing, Imaging technologies, Image resolution, Arteries, Scanning electron microscopy, Tomography, 3D image processing

Proceedings Article | 24 April 2018 Paper
Proc. SPIE. 10711, Biomedical Imaging and Sensing Conference
KEYWORDS: Endoscopy, Medicine, Gastroenterology, Visualization, Tissues, Imaging systems, Optical coherence tomography, Medical research, Angiography, In vivo imaging

SPIE Journal Paper | 6 July 2017
JBO Vol. 22 Issue 07
KEYWORDS: Radiofrequency ablation, Optical coherence tomography, Tissue optics, Esophagus, Real time imaging, System identification, Tumor growth modeling, Quantitative analysis, Tissues, Visualization

Proceedings Article | 14 March 2016 Presentation + Paper
Proc. SPIE. 9712, Multiphoton Microscopy in the Biomedical Sciences XVI
KEYWORDS: Breast, Microscopes, Femtosecond phenomena, Real time imaging, Multiphoton microscopy, Breast cancer, Tissues, Imaging systems, Image processing, Pathology, Luminescence, Collagen, Computer aided design, Tissue optics

Proceedings Article | 4 March 2014 Paper
Proc. SPIE. 8927, Endoscopic Microscopy IX; and Optical Techniques in Pulmonary Medicine
KEYWORDS: Endoscopy, Medicine, Tissues, Imaging systems, Optical coherence tomography, Angiography, Vertical cavity surface emitting lasers, In vivo imaging, Esophagus, 3D image processing

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