Medical Image Registration (MIR) is a challenge that arises in many image processing applications when multiple images must be aligned. We deal with the case of multi-modalities that is approached as an optimization problem. In MIR deterministic algorithms are used mainly, the disadvantage is that many of them get trapped in local optima, especially in multi-modal registration. This work aims to overcome this disadvantage using Scatter Search and Particle Swarm as optimization algorithms, with the mutual information approach proposed by Mattes et. al. The proposed optimizers were tested and contrasted with Reference Algorithms. A multi-modal rigid 3D / 3D of brain medical image registration scheme was implemented, and it was validated in RIRE project. The qualitative and quantitative validation of the results was satisfactory; the results demonstrated the accuracy and applicability of the proposed methods in comparison to conventional methods, as well as not being trapped in local optima.
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