Classical multi-(two-)dimensional separations in gas chromatography (GC) require switching systems to transfer the gas
flow stream from the first to second dimension. This can be accomplished by valve systems, but is more suitably effected
by pressure balanced systems, such as the Deans' switch method. Recent developments in microfluidics and related
micro-technologies should make gas phase switching much more effective. The capillary flow technology platform of
Agilent Technologies is an example of recent developments introduced to GC. Thus various Deans' switch pressure
balanced devices, stream splitters, and column couplings bring new capabilities to analytical GC. We are uniquely placed
to take advantage of the new devices, owing to our development of advanced operational methods in GC which can
make use of microfluidic capillary couplings, and novel cryogenic approaches that deliver performance previously
impossible with conventional methods. Multidimensional chromatographic flow switching to isolate pure compounds
from complex mixtures suggests many potential applications for enhanced chemical analysis. Multiple dimensions of GC
analysis, capabilities for integrating different spectroscopic detection methods for chemical identification of isolated
chemical species including mass spectrometry, nuclear magnetic resonance and Fourier transform infrared, can be
proposed. Applications in the essential oils and petrochemical area will be outlined.
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