Dr. Polina A. Timoshina Profile

Dr. Polina A. Timoshina

Assistant Professor and Engineer at Saratov State Univ

SPIE Involvement:

Author

Publications (10)

Proceedings Article | 9 April 2020 Paper

Speckle-contrast imaging of pathological tissue microhemodynamics in the development of various diabetes models

Polina Dyachenko (Timoshina), Denis Alexandrov, Alla Bucharskaya, Valery Tuchin

Proceedings Volume 11457, 114570K (2020) https://doi.org/10.1117/12.2564100

KEYWORDS: Blood circulation, Blood, Animal model studies, Pancreas, Laser speckle contrast imaging, Speckle imaging, Speckle, Optical clearing, Tissues, Glucose

Read Abstract +

Proceedings Article | 8 April 2020 Presentation

Study tissue microhemodynamics in area of tumor at optical clearing by speckle-contrast imaging (Conference Presentation)

Polina Dyachenko Timoshina, Alla Bucharskaya, Valery Tuchin, Aleksandr Shkurinov

Proceedings Volume 11363, 113631Q (2020) https://doi.org/10.1117/12.2554992

Read Abstract +

The results of an experimental study of changes in the microcirculation of subcutaneous blood flow in a malignant tumor using laser speckle contrast imaging (LSCI) using an optical clearing agent of 70% glycerol solution are presented. In this study, for hemodynamic monitoring we used the speckle contrast method, which is one of the laser speckle imaging methods. This method is based on calculation of contrast of time-averaged dynamic speckles in dependence on the exposure time at the registration of the speckle-modulated images. Analysis of change of hemodynamic was carried out depending on the stage of development of pathologyIn research, we used 15 white laboratory rats Wistar weighing 300-500 g. A tumor was inoculated in laboratory rats by subcutaneous injection of 0.5 ml of a 25% tumor suspension into the area of the shoulder blades in a Hanks solution strain of PC1 alveolar liver cancer. Laboratory animals were divided into three groups, the first included healthy animals, the second - animals with an inoculated tumor 14 days after injection and the third - animals with an inoculated tumor 28 days after injection. It was found that the blood flow rate in pathological group No. 2 was reduced by 25% relative to control measurements of group No. 1, in pathological group No. 3 increased by 20% relative to control measurements. Also, the results showed that the use of a 70% glycerol solution reduced the blood flow velocity in the control group by about 2 times. Moreover, in pathological groups, the effect of the solution on the blood flow is more pronounced, in the group, the measurements on which were carried out 14 days after the inoculation of the tumor, the blood flow rate decreased by 2.8 times, after 28 days - by 4 times. The results obtained in the study of disorders of the microcirculation of the subcutaneous blood flow under the conditions of the development of a malignant tumor show that the development of diseases in animals causes changes in the microcirculatory system, and the use of optical clearing agents demonstrates changes in vascular permeability under conditions of the development of pathologies.

Proceedings Article | 1 March 2019 Paper

Speckle-contrast imaging of pathological tissue microhemodynamics at optical clearing

Polina Timoshina, Alla Bucharskaya, Nikita Navolokin, Valery Tuchin

Proceedings Volume 10877, 108770Z (2019) https://doi.org/10.1117/12.2508794

KEYWORDS: Blood circulation, Blood, Laser speckle contrast imaging, Optical clearing, Speckle, Pancreas, Tissue optics, Speckle imaging, Animal model studies, Tissues

Read Abstract +

SPIE Journal Paper | 23 August 2018 Open Access

Measurement of tissue optical properties in the context of tissue optical clearing

Alexey Bashkatov, Kirill Berezin, Konstantin Dvoretskiy, Maria Chernavina, Elina Genina, Vadim Genin, Vyacheslav Kochubey, Ekaterina Lazareva, Alexander Pravdin, Marina Shvachkina, Polina Timoshina, Daria Tuchina, Dmitry Yakovlev, Irina Yu Yanina, Olga Zhernovaya, Valery Tuchin

JBO, Vol. 23, Issue 09, 091416, (August 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.9.091416

KEYWORDS: Tissue optics, Tissues, Optical properties, Skin, Collagen, Blood, Optical clearing, Optical coherence tomography, Optical testing, Scattering

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 24 March 2017 Paper

Laser speckle contrast imaging of cerebral blood flow of newborn mice at optical clearing

Polina Timoshina, Ekaterina Zinchenko, Daria Tuchina, Madina Sagatova, Oxana Semyachkina-Glushkovskaya, Valery Tuchin

Proceedings Volume 10336, 1033610 (2017) https://doi.org/10.1117/12.2268358

KEYWORDS: Optical clearing, Cerebral blood flow, Skin, Blood, Laser speckle contrast imaging, Speckle, Tissues, Blood circulation, Biomedical optics, Optical coherence tomography, Tissue optics

Read Abstract +

Proceedings Article | 19 March 2015 Paper

Comparison of cerebral microcirculation of alloxan diabetes and healthy mice using laser speckle contrast imaging

Polina Timoshina, Rui Shi, Yang Zhang, Dan Zhu, Oxana Semyachkina-Glushkovskaya, Valery Tuchin, Qingming Luo

Proceedings Volume 9448, 94480B (2015) https://doi.org/10.1117/12.2179988

KEYWORDS: Glucose, Blood circulation, Brain, Veins, Blood, Speckle, Blood vessels, Laser speckle imaging, Animal model studies, Laser speckle contrast imaging

Read Abstract +

Proceedings Article | 19 March 2015 Paper

Advanced digital methods for blood flow flux analysis using µPIV approach

Maxim Kurochkin, Polina Timoshina, Ivan Fedosov, Valery Tuchin

Proceedings Volume 9448, 94481A (2015) https://doi.org/10.1117/12.2179974

KEYWORDS: Capillaries, Blood circulation, Blood, Microscopes, In vivo imaging, Stomach, Confocal microscopy, Microscopy, Ions, Biomedical optics

Read Abstract +

Proceedings Article | 28 February 2014 Paper

Optical clearing method for monitoring cutaneous microcirculation response to vasoactive drugs with high sensitivity

Rui Shi, Min Chen, Ruilin Wang, Cong Ma, Junbo Jin, Yuhua Lu, Polina Timoshina, Valery Tuchin, Dan Zhu

Proceedings Volume 8951, 89510W (2014) https://doi.org/10.1117/12.2038446

KEYWORDS: Skin, Blood circulation, Optical clearing, Laser speckle contrast imaging, Blood vessels, Speckle, Ions, Tissue optics, Scattering, Blood

Read Abstract +

Proceedings Article | 8 May 2012 Paper

Monitoring of the microhemodynamic in an aggressive clinical behavior of cerebral hemorrhage using dynamic light scattering techniques

M. Vilensky, O. Semyachkina-Glushkovskaya, P. Timoshina, V. Berdnikova, Y. Kuznetsova, I. Semyachkin-Glushkovsky, D. Agafonov, V. Tuchin

Proceedings Volume 8427, 842747 (2012) https://doi.org/10.1117/12.924098

KEYWORDS: Tissues, Laser scattering, Scattering, Light scattering, Speckle, Hemodynamics, Dynamic light scattering, Statistical analysis, Blood circulation, Blood

Read Abstract +

Proceedings Article | 3 March 2011 Paper

Full-field speckle correlation technique as applied to blood flow monitoring

M. Vilensky, D. Agafonov, P. Timoshina, O. Shipovskaya, D. Zimnyakov, V. Tuchin, P. Novikov

Proceedings Volume 7898, 78981C (2011) https://doi.org/10.1117/12.879890

KEYWORDS: Ischemia, Speckle, Blood circulation, Intestine, Stomach, Blood, Hemodynamics, Statistical analysis, Pathology, Laser tissue interaction

Read Abstract +

Showing 5 of 10 publications

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Keywords/Phrases

Search In:

Publication Years