Dr. Richard B. Dorshow Profile

Dr. Richard B. Dorshow

Chief Scientific Officer at MediBeacon Inc.

SPIE Involvement:

Conference Program Committee | Author

Publications (30)

Proceedings Article | 7 March 2019 Paper

Noninvasive point-of-care measurement of gastrointestinal permeability

Richard Dorshow, J. Johnson, Martin Debreczeny, I. Rochelle Riley, Jeng-Jong Shieh, Thomas Rogers, Carla Hall-Moore, Nurmohammad Shaikh, Phillip Tarr

Proc. SPIE. 10893, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XI

KEYWORDS: Point-of-care devices, Calibration, Luminescence, Fluorescence spectroscopy, Fluorescent markers, Skin optics, Absorption

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SPIE Journal Paper | 11 May 2018

Transdermal optical renal function monitoring in humans: development, verification, and validation of a prototype device

Martin Debreczeny, Richard Dorshow

JBO Vol. 23 Issue 05

KEYWORDS: Luminescence, Sensors, Kidney, Ear, Skin, Prototyping, Signal to noise ratio, Scattering, In vivo imaging, In vitro testing

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Proceedings Article | 21 February 2017 Presentation + Paper

Modeling of transdermal fluorescence measurements from first-in-human clinical trials for renal function determination using fluorescent tracer agent MB-102

Kimberly Shultz, Martin Debreczeny, Richard Dorshow, Jennifer Keating, Kate Bechtel

Proc. SPIE. 10079, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IX

KEYWORDS: Mathematical modeling, Optical properties, Scattering, Blood, Skin, Diffusion, Fluorescence spectroscopy, Monte Carlo methods, Kidney, Tissue optics, Signal detection, Light, Instrument modeling

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Proceedings Article | 21 February 2017 Presentation + Paper

Development and clinical trial results of a prototype device for trans-cutaneous monitoring of kidney function

Martin Debreczeny, Richard Dorshow

Proc. SPIE. 10079, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IX

KEYWORDS: Signal to noise ratio, Light emitting diodes, Sensors, Blood, Skin, Luminescence, Kidney, Prototyping, Plasma, Medical device development, Clinical trials

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Proceedings Article | 22 April 2016 Paper

Application of fluorescent tracer agent technology to point-of-care gastrointestinal permeability measurement

Richard Dorshow, Jeng-Jong Shieh, Thomas Rogers, Carla Hall-Moore, Nurmohammad Shaikh, Michael Talcott, Phillip Tarr

Proc. SPIE. 9723, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VIII

KEYWORDS: Target detection, Eye, Medicine, Statistical analysis, Point-of-care devices, Luminescence, Diagnostics, Fluorescent markers, Optical testing, Nanomaterials, Kidney, In vivo imaging, In vitro testing, Absorption, Animal model studies

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Proceedings Article | 12 March 2015 Paper

Results of the first-in-human clinical trial for MB-102, a novel fluorescent tracer agent for real-time measurement of glomerular filtration rate

Richard Dorshow, Martin Debreczeny, Thomas Dowling

Proc. SPIE. 9339, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VII

KEYWORDS: Safety, Injuries, Data modeling, Blood, Toxicity, Kidney, In vivo imaging, Plasma, Clinical trials, Animal model studies

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Proceedings Article | 5 March 2014 Paper

Initial formal toxicity evaluation of APC-2, a novel fluorescent tracer agent for real-time measurement of glomerular filtration rate in preparation for a first-in-man clinical trial

Joseph Bugaj, Richard Dorshow

Proc. SPIE. 8956, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VI

KEYWORDS: Safety, Blood, Pathology, Skin, Toxicity, Electrocardiography, Vehicle control, Pharmacology, Plasma, Clinical trials

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Proceedings Article | 21 February 2013 Paper

Real-time point-of-care measurement of impaired renal function in a rat acute injury model employing exogenous fluorescent tracer agents

Richard Dorshow, Richard Fitch, Karen Galen, Jolette Wojdyla, Amruta Poreddy, John Freskos, Raghavan Rajagopalan, Jeng-Jong Shieh, Sevag Demirjian

Proc. SPIE. 8596, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V

KEYWORDS: Injuries, Biomedical optics, Point-of-care devices, Fiber optics, Skin, Kidney, In vivo imaging, Analog electronics, Systems modeling, Plasma

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Proceedings Article | 21 February 2012 Paper

Picosecond polarization spectroscopy of fluorescein attached to different molecular volume polymer influenced by rotational motion

Yang Pu, Wubao Wang, R. Dorshow, R. Alfano

Proc. SPIE. 8258, Organic Photonic Materials and Devices XIV

KEYWORDS: Polarization, Polymers, Spectroscopy, Luminescence, Molecules, Fluorescence spectroscopy, Picosecond phenomena, Molecular spectroscopy, Time resolved spectroscopy, Anisotropy

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Proceedings Article | 19 February 2011 Paper

Human skin auto-fluorescence decay as a function of irradiance and skin type

Martin Debreczeny, Rebecca Bates, Rick Fitch, Karen Galen, Jiajia Ge, Richard Dorshow

Proc. SPIE. 7897, Optical Interactions with Tissue and Cells XXII

KEYWORDS: Fiber optics, Tissues, Blood, Blood vessels, Skin, Luminescence, Chromophores, Tissue optics, Systems modeling, Instrument modeling

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Proceedings Article | 12 February 2011 Paper

Development of fluorescent tracers for the real-time monitoring of renal function

Amruta Poreddy, Bethel Asmelash, Martin Debreczeny, Richard Fitch, John Freskos, Karen Galen, Kimberly Gaston, James Kostelc, Rana Kumar, Tim Marzan, William Neumann, Raghavan Rajagopalan, Tasha Schoenstein, Jeng-Jong Shieh, J. Micah Wilcox, Jolette Wojdyla, Richard Dorshow

Proc. SPIE. 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III

KEYWORDS: Proteins, Blood, Luminescence, Molecules, In vivo imaging, Tissue optics, Analog electronics, In vitro testing, Plasma, Lead

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Proceedings Article | 8 February 2011 Paper

Folate receptor targeted Type 1 photosensitizer bioconjugates for tumor visualization and phototherapy

Raghavan Rajagopalan, Amruta Poreddy, Amolkumar Karwa, Bethel Asmelash, Nicole Putnam, Lori Chinen, Maureen Nichols, J. Jeng Shieh, Richard Dorshow

Proc. SPIE. 7886, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX

KEYWORDS: Confocal microscopy, Phototherapy, Photodynamic therapy, Cancer, Tumors, Sensors, Receptors, In vitro testing, Ovarian cancer, Photosensitizer targeting

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Proceedings Article | 3 March 2010 Paper

Novel visible light activated type 1 photosensitizers

Raghavan Rajagopalan, Amolkumar Karwa, Amruta Poreddy, Przemyslaw Lusiak, Raghoottama Pandurangi, Gary Cantrell, Richard Dorshow

Proc. SPIE. 7551, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX

KEYWORDS: Visible radiation, Phototherapy, Photodynamic therapy, Tumors, Ultraviolet radiation, Control systems, Oxygen, Cell death, Leukemia, In vitro testing

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Proceedings Article | 3 March 2010 Paper

In vitro biological effects of novel type I photosensitizers and their mechanism of action

Amolkumar Karwa, Raghavan Rajagopalan, Amruta Poreddy, Carolyn Sympson, Gary Cantrell, Richard Dorshow

Proc. SPIE. 7551, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX

KEYWORDS: Visible radiation, Phototherapy, Photodynamic therapy, Ultraviolet radiation, Luminescence, Chemistry, Lamps, Oxygen, Cell death, In vitro testing

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Proceedings Article | 13 July 2009 Paper

Novel type 1 photosensitizers: viability of leukemia cells exposed to reactive intermediates generated in situ by in vitro photofragmentation

Raghavan Rajagopalan, Amol Karwa, Przemyslaw Lusiak, Kripa Srivastava, Amruta Poreddy, Raghootama Pandurangi, Karen Galen, William Neumann, Gary Cantrell, Richard Dorshow

Proc. SPIE. 7380, Photodynamic Therapy: Back to the Future

KEYWORDS: Phototherapy, Photodynamic therapy, Tumors, Ultraviolet radiation, Control systems, Oxygen, Cell death, Leukemia, In vitro testing, Photosensitizer targeting

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Proceedings Article | 21 February 2009 Paper

N-alkylated aminopyrazines for use as hydrophilic optical agents

Amruta Poreddy, Bethel Asmelash, Karen Galen, Richard Fitch, Jeng-Jong Shieh, James Wilcox, Tasha Schoenstein, Jolette Wojdyla, Kimberly Gaston, John Freskos, William Neumann, Raghavan Rajagopalan, Hyo-Yang Ahn, James Kostelc, Martin Debreczeny, Kevin Belfield, Richard Dorshow

Proc. SPIE. 7190, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications

KEYWORDS: Proteins, Blood, Luminescence, Molecules, Kidney, Ear, In vivo imaging, Tissue optics, Plasma, Absorption

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Proceedings Article | 22 February 2008 Paper

Fluorescence-enhanced europium complexes for the assessment of renal function

Lori Chinen, Karen Galen, K. Kuan, Mary Dyszlewski, Hiroaki Ozaki, Hiroaki Sawai, Raghootama Pandurangi, Frederick Jacobs, Richard Dorshow, Raghavan Rajagopalan

Proc. SPIE. 6867, Molecular Probes for Biomedical Applications II

KEYWORDS: Liver, Tissues, Blood, Metals, Luminescence, Kidney, Antennas, Fluorescence resonance energy transfer, Forward error correction, Europium

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Proceedings Article | 22 February 2008 Paper

New optical probes for continuous monitoring of renal function

Richard Dorshow, Bethel Asmelash, Lori Chinen, Martin Debreczeny, Richard Fitch, John Freskos, Karen Galen, Kimberly Gaston, Timothy Marzan, Amruta Poreddy, Raghavan Rajagopalan, Jeng-Jong Shieh, William Neumann

Proc. SPIE. 6867, Molecular Probes for Biomedical Applications II

KEYWORDS: Proteins, Veins, Blood, Synthetic aperture radar, Luminescence, Molecules, Fluorescence spectroscopy, Ear, In vivo imaging, Plasma

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Proceedings Article | 4 April 2005 Paper

Unexpected long-term stability of a cyanine dye bioconjugate

Richard Dorshow, Raghavan Rajagopalan

Proc. SPIE. 5704, Genetically Engineered and Optical Probes for Biomedical Applications III

KEYWORDS: Optical imaging, Near infrared, Tumors, Blood, Glasses, Luminescence, Fluorescence spectroscopy, Charge-coupled devices, Receptors, In vivo imaging

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Proceedings Article | 14 June 2004 Paper

Targeting the expression of integrin receptors in tumors

Sharon Bloch, Kexian Liang, Richard Dorshow, Yunpeng Ye, Samuel Achilefu

Proc. SPIE. 5329, Genetically Engineered and Optical Probes for Biomedical Applications II

KEYWORDS: Optical imaging, Near infrared, Liver, Tumors, Tissues, Blood, Pancreas, Kidney, Receptors, Lung cancer

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Proceedings Article | 2 July 2001 Paper

New approach to optical imaging of tumors

Samuel Achilefu, Joseph Bugaj, Richard Dorshow, Hermo Jimenez, Raghavan Rajagopalan

Proc. SPIE. 4259, Biomarkers and Biological Spectral Imaging

KEYWORDS: Optical imaging, Tumor growth modeling, Tumors, Tissues, Luminescence, Molecules, Solids, Receptors, In vivo imaging, Animal model studies

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Proceedings Article | 2 July 2001 Paper

Targeted Type 1 phototherapeutic agents using azido-peptide bioconjugates

Raghavan Rajagopalan, Samuel Achilefu, Hermo Jimenez, Elizabeth Webb, Michelle Schmidt, Joseph Bugaj, Richard Dorshow

Proc. SPIE. 4259, Biomarkers and Biological Spectral Imaging

KEYWORDS: Near infrared, Phototherapy, Tumors, Tissues, Energy transfer, Oxygen, Solids, Receptors, Lung cancer, Tissue optics

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SPIE Journal Paper | 1 April 2001

Novel fluorescent contrast agents for optical imaging of in vivo tumors based on a receptor-targeted dye-peptide conjugate platform

Joseph Bugaj, Samuel Achilefu, Richard Dorshow, Raghavan Rajagopalan

JBO Vol. 6 Issue 02

KEYWORDS: Tumors, Receptors, Luminescence, Tissues, In vivo imaging, Optical imaging, Solids, Tissue optics, Liver, Animal model studies

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Proceedings Article | 31 January 2001 Paper

Site-specific tumor-targeted fluorescent contrast agents

Samuel Achilefu, Joseph Bugaj, Richard Dorshow, Hermo Jimenez, Raghavan Rajagopalan, R. Randy Wilhelm, Elizabeth Webb, Jack Erion

Proc. SPIE. 4156, Clinical Lasers and Diagnostics

KEYWORDS: Cancer, Tumors, Tissues, Blood, Luminescence, Molecules, Solids, Receptors, In vivo imaging, In vitro testing

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Proceedings Article | 26 April 2000 Paper

Polyionic fluorescent bioconjugates as tracer agents for continuous monitoring of renal function

Raghavan Rajagopalan, Joseph Bugaj, Richard Dorshow, C. Venkatramani, Pamela Uetrecht, Samuel Achilefu

Proc. SPIE. 3924, Molecular Imaging: Reporters, Dyes, Markers, and Instrumentation

KEYWORDS: Liver, Blood, Luminescence, Molecules, Time metrology, Kidney, Sodium, Chlorine, Medium wave, Micro optical fluidics

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Proceedings Article | 19 April 2000 Paper

Tumor-specific fluorescent contrast agents

Samuel Achilefu, Richard Dorshow, Joseph Bugaj, Raghavan Rajagopalan

Proc. SPIE. 3917, Optical Biopsy III

KEYWORDS: Target detection, Optical imaging, Liver, Tumors, Tissues, Luminescence, Inflammation, Solids, Receptors, In vivo imaging

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Proceedings Article | 2 July 1999 Paper

Time-resolved fluorescence polarization dynamics and imaging of fluorescein dye attached to different molecular weight chains

Wubao Wang, J. Ali, Richard Dorshow, Margaret McLoughlin, Robert Alfano

Proc. SPIE. 3600, Biomedical Imaging: Reporters, Dyes, and Instrumentation

KEYWORDS: Polarization, Tissues, Scattering media, Polymers, Molecules, Picosecond phenomena, Time resolved spectroscopy, Molybdenum, Ultrafast laser spectroscopy, Visibility

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Proceedings Article | 17 May 1999 Paper

Monitoring physiological function by detection of exogenous fluorescent contrast agents

Richard Dorshow, Joseph Bugaj, Samuel Achilefu, Raghavan Rajagopalan, Arthur Combs

Proc. SPIE. 3599, Optical Diagnostics of Biological Fluids IV

KEYWORDS: Veins, Fiber optics, Blood, Luminescence, Fluorescence spectroscopy, Indocyanine green, Ear, In vivo imaging, Chlorine, In vitro testing

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SPIE Journal Paper | 1 July 1998

Noninvasive fluorescence detection of hepatic and renal function

Richard Dorshow, Joseph Bugaj, B. Burleigh, James Duncan, Michael Johnson, William Jones

JBO Vol. 3 Issue 03

KEYWORDS: Luminescence, Liver, Fluorescence spectroscopy, In vivo imaging, Ear, Signal detection, Blood, Kidney, Systems modeling, Sensors

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Proceedings Article | 19 June 1998 Paper

Noninvasive fluorescence detection of physiological function

Richard Dorshow, Joseph Bugaj

Proc. SPIE. 3252, Optical Diagnostics of Biological Fluids III

KEYWORDS: Liver, Data modeling, Fiber optics, Blood, Luminescence, Fluorescence spectroscopy, Kidney, Ear, In vivo imaging, Signal detection

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Showing 5 of 30 publications

Conference Committee Involvement (18)

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIV

22 January 2022 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIII

6 March 2021 | Online Only, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII

4 February 2020 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XI

4 February 2019 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications X

29 January 2018 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IX

30 January 2017 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VIII

15 February 2016 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VII

9 February 2015 | San Francisco, California, United States