Dr. Richard Straight Profile

Dr. Richard Straight

Consultant

Area of Expertise:

Biomedical Photonics , Medical Antibodies , Photodynamic Therapy

Proceedings Article | 28 July 1994 Paper

Light-emitting diode arrays and photodynamic therapy: a progress report

Kenneth Schlager, Richard Straight

Proceedings Volume 2131, (1994) https://doi.org/10.1117/12.180731

KEYWORDS: Light emitting diodes, Photodynamic therapy, Light sources, Tissue optics, Power supplies, Liquids, Dye lasers, Semiconductor lasers, Cancer, Oncology

Read Abstract +

Proceedings Article | 1 June 1992 Paper

Polymer-bound meso-chlorin e6 for PDT (Invited Paper)

Nancy Krinick, Ying Sun, D. Joyner, R. Reed, John Spikes, Richard Straight, Jindrich Kopecek

Proceedings Volume 1645, (1992) https://doi.org/10.1117/12.60937

KEYWORDS: Polymers, Tumors, Photodynamic therapy, In vivo imaging, Tissues, Oxygen, Quantum efficiency, Tumor growth modeling, In vitro testing, Photosensitizer targeting

Read Abstract +

Two types of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer containing meso- chlorin e₆ monoethylene diamine disodium salt (Mce₆) were synthesized. The Mce₆ was bound via pendant enzymatically degradable oligopeptide side chains (G-F-L-G) in one copolymer and was attached through noncleavable side chains (G) in the other. Preliminary experiments have been undertaken to compare their localization/retention behavior and their tumorcidal activity in vivo (A/J mice; C1300 neuroblastoma). Results of localization/retention experiments indicated that the Mce₆ bound to the noncleavable copolymer was retained in the tumor and other tissues for a prolonged time period compared with free Mce₆ or the Mce₆ bound to the cleavable copolymer. Light activation of the Mce₆ from the cleavable copolymer rendered a substantially more potent biological response in vivo than did the permanently bound Mce₆. It is hypothesized and indirectly supported by photophysical data that both of the polymer-photosensitizer complexes are aggregated (or conformationally altered) under physiological conditions due to their hydrophilic/hydrophobic properties. In buffer at pH 7.4, the quantum yield of singlet oxygen generation by free Mce₆ is three-fold higher than by the Mce₆ bound to a noncleavable copolymer; adding detergent (CTAB), increased the quantum yield of singlet oxygen generation to a value consistent with that of the free Mce₆. In vivo, if a sufficient time lag is allowed after drug administration for tumor cell lysosomal enzymes to cleave the Mce₆ from the polymer containing degradable side chains, the Mce₆ would be released in free form and behave with properties akin to the free drug. Due to the difference in cellular uptake mechanisms for free and bound drugs (and the targeting potential of the copolymer), a much higher local concentration in the tumor compared with surrounding tissue can be achieved with the polymer bound drug than the free photosensitizer. Side effects characteristics of current PDT treatment such as light ultrasensitivity in skin may be reduced by improving localization selectivity.

Proceedings Article | 1 February 1992 Paper

Selective photothermotherapy and spectroscopy of spectrally and spatially heterogenous biological targets with ultrafast laser pulses

Richard Straight

Proceedings Volume 1599, (1992) https://doi.org/10.1117/12.2322300

KEYWORDS: Spectroscopy, Ultrafast lasers, Ultrafast phenomena, Laser applications, Absorption, Chromophores, Photomedicine, Ultrafast laser spectroscopy, Refractive index, Light scattering

Read Abstract +

Proceedings Article | 1 June 1990 Paper

Biological consequences of fiber fragmentation with pulsed laser lithotripsy

Erich Bruhn, Peter Go, Robert McClane, John Hunter, Richard Straight

Proceedings Volume 1200, (1990) https://doi.org/10.1117/12.17444

KEYWORDS: Laser lithotripsy, Laser therapeutics, Fiber lasers, Nd:YAG lasers, Tissues, Glasses, Q switched lasers, Quartz, Laser energy, Laser vision correction

Read Abstract +

Proceedings Article | 1 June 1990 Paper

On-off time control of laser pulses for pseudo-constant temperature coagulation in tissue

Gilwon Yoon, Serge Mordon, Jean Marc Brunetaud, Radouan Faiz, Richard Straight, Pierre Bugnon, Marcel Staroswiecki, J. Leroux

Proceedings Volume 1202, (1990) https://doi.org/10.1117/12.17632

KEYWORDS: Laser tissue interaction, Temperature metrology, Thulium, Tissues, Cameras, Thermal modeling, Beam controllers, Pulsed laser operation, Tissue optics, Natural surfaces

Read Abstract +

Proceedings Article | 1 June 1990 Paper

In-vitro CCD measurements of light distributions from diffusing optical fiber tips used in photodynamic therapy

Robert Benner, Robert McClane, John Dixon, Richard Straight

Proceedings Volume 1202, (1990) https://doi.org/10.1117/12.17616

KEYWORDS: Luminescence, Fiber lasers, Photodynamic therapy, Charge-coupled devices, Light, Tumors, Optical fibers, Laser tissue interaction, Optical testing, Imaging systems

Read Abstract +

Proceedings Article | 21 January 1990 Paper

Optical-CCD system for imaging light and drug distributions in tumors for phototherapy

R. Straight

Proceedings Volume 10306, 103060K (1990) https://doi.org/10.1117/12.2283682

Read Abstract +

Showing 5 of 7 publications

Conference Committee Involvement (1)

Optical Biopsy V

27 January 2004 | San Jose, CA, United States

Keywords/Phrases

Search In:

Publication Years