Mr. Richard Cody Stringer Profile

Richard Cody Stringer

at Univ of Missouri-Columbia

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Proceedings Article | 24 April 2010 Paper

Use of quantum dot-labeled imprinted polymer microparticles for detection of nitroaromatic compounds

R. Cody Stringer, Shubhra Gangopadhyay, Sheila Grant

Proceedings Volume 7673, 767304 (2010) https://doi.org/10.1117/12.852913

KEYWORDS: Polymers, Sensors, Particles, Luminescence, Explosives, Quantum dots, Molecules, Explosives detection, Polymerization, Spherical lenses

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The ability to detect high explosive compounds is a fundamental step in achieving the goal of creating devices capable of 'sniffing' out explosive devices. To detect high explosive compounds such as 2,4,6-trinitrotoluene (TNT), a molecularly imprinted polymer (MIP) sensor was developed. This sensor consists of MIP microspheres prepared using methacrylic acid as the functional monomer in a precipitation polymerization reaction. The MIP microspheres are then combined with fluorescent semiconductor nanocrystals, or quantum dots, via a simple crosslinking procedure. To study the sensor's ability to detect nitroaromatic analytes, the fluorescent-labeled MIP particles were exposed to aqueous 2,4- dinitrotoluene (DNT), a nitroaromatic molecule very similar to TNT. Characterization of the MIP particles shows a uniform size distribution, with an average diameter of approximately 615 nm. Imaging of the particles also shows that spherical shapes are being produced by the precipitation polymerization reaction. Preliminary data indicate that the sensor is capable of detecting nitroaromatic compounds in an aqueous solution. These results illustrate the future application of the fluorescent-labeled MIP sensor for detecting high explosives, with the potential for use in detecting vapors from explosive devices and in an array of environmental conditions.

Proceedings Article | 5 May 2009 Paper

Fluorescent imprinted polymers for detection of explosive nitro-aromatic compounds

R. Cody Stringer, Shubhra Gangopadhyay, Sheila Grant

Proceedings Volume 7303, 73031R (2009) https://doi.org/10.1117/12.818768

KEYWORDS: Quantum dots, Luminescence, Polymers, Sensors, Explosives, Molecules, Explosives detection, Particles, Biological research, Biosensors

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Molecular recognition is an important aspect of any biosensor system. Due to increased stability in a variety of environmental conditions, molecular imprinted polymer (MIP) technology is an attractive alternative to biological-based recognition. This is particularly true in the case of improvised explosive device detection, in which the sensor must be capable of detecting trace amounts of airborne nitroaromatic compounds. In an effort to create a sensor for detection of explosive devices via nitroaromatic vapor, MIPs have been deployed as a molecular recognition tool in a fluorescence-based optical biosensor. These devices are easily scalable to a very small size, and are also robust and durable. To achieve such a sensor scheme, polymer microparticles synthesized using methacrylic acid monomer and imprinted with a 2,4-dinitrotoluene (DNT) template were fabricated. These microparticles were then conjugated with green CdSe/ZnS quantum dots, creating fluorescent MIP microparticles. When exposed to the DNT template, rebinding occurred between the DNT and the imprinted sites of the MIP microparticles. This brings the nitroaromatic DNT into close proximity to the quantum dots, allowing the DNT to accept electrons from the fluorescent species, thereby quenching the fluorescence of the quantum dot. Results indicate that this novel method for synthesizing fluorescent MIPs and their integration into an optical biosensor produced observable fluorescence quenching upon exposure to DNT.

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