Dr. Rohith K. Reddy Profile

Dr. Rohith K. Reddy

Assistant Professor at Univ of Houston

SPIE Involvement:

Conference Program Committee | Author

Proceedings Article | 13 March 2024 Presentation

Enhancing cancer tissue analysis using photothermal mid-infrared spectroscopic imaging

Chalapathi Gajjela, Ragib Ishrak, Xinyu Wu, Reza Reihani, David Mayerich, Rohith Reddy

Proceedings Volume PC12855, PC128550X (2024) https://doi.org/10.1117/12.3003048

KEYWORDS: Imaging spectroscopy, Biomedical optics, Tissues, Spectroscopy, Cancer, Mid-IR, Infrared imaging, FT-IR spectroscopy, Chemical analysis, Bone

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Proceedings Article | 15 March 2023 Presentation

Biomedical diagnostics and clinical applications of photothermal mid-infrared spectroscopic imaging (Conference Presentation)

Chalapathi Gajjela, Rupali Mankar, Ragib Ishrak, Xinyu Wu, Reza Reihanisaransari, Sharmin Afrose, David Mayerich, Rohith Reddy

Proceedings Volume PC12392, PC123920R (2023) https://doi.org/10.1117/12.2649535

KEYWORDS: Spectroscopy, Imaging spectroscopy, Mid-IR, Cancer, Biomedical optics, Diagnostics, Spectroscopes, Ovarian cancer, FT-IR spectroscopy, Cervical cancer

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Proceedings Article | 7 March 2022 Presentation

Feasibility and safety of tethered capsule endomicroscopy in studying the natural history of Barrett’s esophagus: a multi-center study

Jing Dong, Catriona Grant, Barry Vuong, Norman Nishioka, Anna Huizi Gao, Matthew Beatty, Grace Baldwin, Aaron Bailargeon, Ara Bablouzian, Patricia Grahmann, Nitasha G. Bhat, Emily Ryan, Amilcar Barrios, Paola Leon Alarcon, Sarah Giddings, Tim Ford, Émilie Beaulieu-Ouellet, Seyed Hamid Hosseiny, Irene Lerman, Wolfgang Trasischker, Rohith Reddy, Kanwarpal Singh, Michalina Gora, Daryl Hyun, Lucille Quénéhervé, Michael Wallace, Wolfsen Herbert, Prateek Sharma, Kenneth Wang, Cadman Leggett, John Poneros, Julian Abrams, Charles Lightdale, Samantha Leeds, Mireille Rosenberg, Guillermo Tearney

Proceedings Volume PC11937, PC119370N (2022) https://doi.org/10.1117/12.2610595

KEYWORDS: Esophagus, Optical coherence tomography, Endoscopy, Endomicroscopy, Safety, Tissues, Imaging systems, Biopsy, Diagnostics, Yield improvement

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Proceedings Article | 4 March 2022 Presentation + Paper

Characterization and optimization of coupled-wave simulations for complex heterogeneous samples

Ruijiao Sun, Rohith Reddy, David Mayerich

Proceedings Volume 11995, 119950G (2022) https://doi.org/10.1117/12.2609179

KEYWORDS: Refractive index, Wave propagation, Statistical modeling, Spatial frequencies, Mie scattering, Microscopy, Finite element methods, Spectroscopy, Magnetism, Inverse problems

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Proceedings Article | 2 March 2022 Presentation

Photothermal Spectroscopic imaging for gynecologic cancer diagnosis and study of bone disorders

Chalapathi Gajjela, Rupali Mankar, Xinyu Wu, Sharmin Afrose, Camille Artur, David Mayerich, Rohith Reddy

Proceedings Volume PC11973, PC119730H (2022) https://doi.org/10.1117/12.2610064

KEYWORDS: Spectroscopy, Bone, Imaging spectroscopy, Cancer, Tissue optics, FT-IR spectroscopy, Tissues, Ovarian cancer, Mid-IR, Machine learning

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Proceedings Article | 5 March 2021 Presentation

Photothermal spectroscopic imaging for ovarian and bone disorders

Rohith Reddy, Chalapathi Gajjela, Rupali Mankar, David Mayerich

Proceedings Volume 11656, 116560L (2021) https://doi.org/10.1117/12.2578622

KEYWORDS: Spectroscopy, Imaging spectroscopy, Bone, Tissues, Tissue optics, FT-IR spectroscopy, Molecular spectroscopy, Mid-IR, Microscopy, Infrared imaging

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Proceedings Article | 4 March 2019 Presentation

Natural history of Barrett’s esophagus using tethered capsule OCT endomicroscopy and portable OCT imaging system: initial experience (Conference Presentation)

Jing Dong, Barry Vuong, Timothy Ford, Matthew Beatty, Seyed Hamid Hosseiny, Emilie Beaulieu-Ouellet, Rohith Reddy, Kanwarpal Singh, Hany Osman, Catriona Grant, Anna Huizi Gao, Samantha Leeds, Norman Nishioka, John Poneros, Julian Abrams, Charles Lightdale, Prateek Sharma, Michael Wallace, Herbert Wolfsen, Kenneth Wang, Cadman Leggett, Mireille Rosenberg, Guillermo Tearney

Proceedings Volume 10867, 108670T (2019) https://doi.org/10.1117/12.2511523

KEYWORDS: Optical coherence tomography, Esophagus, Imaging systems, Endomicroscopy, Endoscopy, Biopsy, 3D image processing, Clinical trials, Image resolution, Tissues

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While the most common method used to evaluate and survey patients with Barrett’s Esophagus (BE) is endoscopic biopsy, this procedure is invasive, time-consuming, and suffers from sampling errors. Moreover, it requires patient sedation that increases cost and mandates its operation in specialized settings. Our lab has developed a new imaging tool termed tethered capsule endomicroscopy (TCE) that involves swallowing a tethered capsule which utilizes optical coherence tomography (OCT) to obtain three-dimensional microscopic (10µm) images of the entire esophageal wall as it traverses the luminal organ via peristalsis or is retrieved by pulling up tether. As opposed to endoscopy, TCE procedure is non-invasive, doesn’t require patient sedation and mitigates sampling error by evaluating the microscopic structure of the entire esophagus. The merits of TCE make it a suitable device to investigate the microscopic natural history of BE in a longitudinal manner. Here, we present our initial experience of a multicenter (5-site) clinical trial to study the microscopic natural history of BE. The TCE device used for the study is the new generation capsule with the ball lens optical configuration and a distal scan stepper motor, which provides 30µm (lateral) resolution and 40Hz imaging rate. The portable OCT imaging system is a custom in-house built swept source system and provides 7µm (axial) at a 100 kHz A-line rate with a center wavelength of ~1310 nm. To date, we have successfully enrolled 69 subjects at all sites (MGH: 33, Columbia University: 11, Kansas City VA: 10, Mayo Jacksonville: 8, Mayo Rochester: 7) and 59 have swallowed the capsule (85.5%). There have been no reported adverse events associated with TCE procedure. High-quality OCT images were reliably obtained from patients who swallowed the device, and BE tissues were identified by expert readers. Our initial experience with TCE in a multicenter study demonstrates that this technology is easy to use and efficient in multiple clinical settings. Completion of this longitudinal study is likely to provide new insights on the temporal progression of BE that may impact management strategies.

Proceedings Article | 14 March 2018 Presentation

Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy (Conference Presentation)

Chia-Pin Liang, Jing Dong, Timothy Ford, Rohith Reddy, Seyed Hamid Hosseiny Darbrazi, Hamid Farrokhi, Matthew Beatty, Kanwarpal Singh, Barry Vuong, Emilie Beaulieu-Ouellet, Catriona Grant, Sarah Giddings, Mireille Rosenberg, Norman Nishioka, Guillermo Tearney

Proceedings Volume 10470, 104700X (2018) https://doi.org/10.1117/12.2287843

KEYWORDS: Laser marking, Optical coherence tomography, Endomicroscopy, Endoscopy, Laser optics, Coherence (optics), Esophagus, Cancer, Surveillance, Diagnostics

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Proceedings Article | 27 April 2016 Presentation

Tethered capsule OCT endomicroscopy for upper gastrointestinal tract imaging by using ball lens probe (Conference Presentation)

Jing Dong, Michalina Gora, Rohith Reddy, Wolfgang Trasischker, Oriane Poupart, Weina Lu, Robert Carruth, Catriona Grant, Amna Soomro, Aubrey Tiernan, Mireille Rosenberg, Norman Nishioka, Guillermo Tearney

Proceedings Volume 9691, 96910R (2016) https://doi.org/10.1117/12.2213931

KEYWORDS: Optics manufacturing, Photomedicine, Optical coherence tomography, Endoscopy, Endomicroscopy, Glasses, GRIN lenses, Optical fibers, Surgery, Visualization

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Proceedings Article | 10 February 2012 Open Access

Denoising and deblurring of Fourier transform infrared spectroscopic imaging data

Tan Nguyen, Rohith Reddy, Michael Walsh, Matthew Schulmerich, Gabriel Popescu, Minh Do, Rohit Bhargava

Proceedings Volume 8296, 82960M (2012) https://doi.org/10.1117/12.921144

KEYWORDS: FT-IR spectroscopy, Absorbance, Data modeling, Imaging spectroscopy, Point spread functions, Spectroscopy, Denoising, Sensors, Image processing, Imaging systems

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Proceedings Article | 20 February 2009 Paper

Validating the cancer diagnosis potential of mid-infrared spectroscopic imaging

F. Nell Pounder, Rohith Reddy, Michael Walsh, Rohit Bhargava

Proceedings Volume 7186, 71860F (2009) https://doi.org/10.1117/12.810122

KEYWORDS: Tissues, FT-IR spectroscopy, Breast, Sensors, Tumors, Image segmentation, Spectral resolution, Cancer, Spectroscopy, Imaging spectroscopy

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Proceedings Article | 8 February 2008 Paper

Practical protocols for fast histopathology by Fourier transform infrared spectroscopic imaging

Frances Keith, Rohith Reddy, Rohit Bhargava

Proceedings Volume 6853, 685306 (2008) https://doi.org/10.1117/12.762468

KEYWORDS: Tissues, FT-IR spectroscopy, Spectral resolution, Signal to noise ratio, Data acquisition, Image classification, Tissue optics, Image segmentation, Breast, Imaging spectroscopy

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Showing 5 of 12 publications

Conference Committee Involvement (6)

Advanced Chemical Microscopy for Life Science and Translational Medicine 2025

25 January 2025 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine 2024

27 January 2024 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine 2023

28 January 2023 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine 2022

23 January 2022 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine 2021

6 March 2021 | Online Only, California, United States

Showing 5 of 6 Conference Committees

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