Endothelial dysfunction represents a key factor in the worsening of the COVID-19 disease in up to 20% of the cases of infection from acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2). The combination of diffuse optics and vascular occlusion tests makes the assessment of endothelial and microvasculature health possible by accessing information about microvascular metabolism, reactivity and tissue perfusion just by performing a localized ischemia at the forearm of the patient. In this framework, we will present a smart platform integrating time-domain near-infrared spectroscopy and diffuse correlation spectroscopy alongside an automatized tourniquet and a pulse-oximeter for personalizing therapies targeting endothelial function and avoid ventilator-induced lung injuries.
We propose a standardized approach for performance assessment and quality-control of the novel VASCOVID system based on optical phantoms. This approach is tailored to meet the requirements of the Medical Device Regulation, and is extendable to other biophotonics devices.
We present a new optical platform that combines broadband near-infrared spectroscopy and diffuse correlation spectroscopy for identification of brain injury severity in a preclinical model of hypoxic-ischemic encephalopathy of the neonatal brain.
The VASCOVID project aims to develop an hybrid diffuse optical device with a vascular occlusion protocol for evaluating endothelial and microvascular health in severe COVID-19 patients admitted to the ICU.
We report implementation of compact cascaded multicrystal scheme for single-pass second-harmonic-generation (SHG), using birefringent crystal, for continuous-wave (cw) deep ultraviolet (UV) generation. The system comprises of 4 cascaded stages, is based on critical phase-matched interaction in β-BaB2O4 (BBO), and pumped by a cw singlefrequency green source at 532 nm. A deep-UV cw output power of 37.7 mW at 266 nm has been obtained with a high passive power stability of 0.12 % rms over more than 4 hours in Gaussian spatial beam quality with a circularity of >70%.
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