Mr. Sayantan Ghosh Profile

Sayantan Ghosh

at Deutsche Sporthochschule Köln

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Proceedings Article | 26 February 2013 Paper

Mueller matrix polarimetry of plasmon resonant silver nano-rods: biomedical prospects

Jalpa Soni, Sayantan Ghosh, Sudipta Bera, Ayan Banerjee, Nirmalya Ghosh

Proceedings Volume 8699, 869902 (2013) https://doi.org/10.1117/12.2016830

KEYWORDS: Polarization, Scattering, Particles, Refractive index, Polarimetry, Silver, Polarizability, Plasmons, Mie scattering, Nanorods

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Fundamental understanding of the light-matter interaction in the context of nano-particles is immensely benefited by the study of geometry dependent tunable Localized Surface Plasmon Resonance (LSPR) and has been demonstrated to have potential applications in various areas of science. The polarization characteristics of LSPR in addition to spectroscopic tuning can be suitably exploited in such systems as contrast enhancement mechanisms and control parameters. Such polarization characteristics like diattenuation and retardance have been studied here using a novel combination of Muller-matrix polarimetry with the T-matrix matrix approach for silver nano-rods to show unprecedented control and sensitivity to local refractive index variations. The study carried out over various aspect ratios for a constant equal volume sphere radius shows the presence of longitudinal (dipolar and quadrupolar) and transverse (dipolar) resonances; arising due to differential contribution of polarizabilities in two directions. The overlap regions of these resonances and the resonances themselves exhibit enhanced retardance and diattenuation respectively. The spectral and amplitude tunability of these polarimetric parameters through the aspect ratios to span from the minimum to maximum ([0, 1] in the case of diattenuation and [0, π] in the case of retardance) presents a novel result that could be used to tailor systems for study of biological media. On the other hand, the high sensitivity of diattenuation dip (caused by equal contribution of polarizabilities) could be possibly used for medium characterization and bio-sensing or bio imaging studies.

Proceedings Article | 23 February 2012 Paper

Wavelet-based multifractal analysis of laser biopsy imagery

Jaidip Jagtap, Sayantan Ghosh, Prasanta Panigrahi, Asima Pradhan

Proceedings Volume 8222, 82220F (2012) https://doi.org/10.1117/12.907330

KEYWORDS: Tissues, Cancer, Wavelets, Biological research, Phase contrast, Biopsy, Raman scattering, Scattering, Light scattering, Refractive index

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In this work, we report a wavelet based multi-fractal study of images of dysplastic and neoplastic HE- stained human cervical tissues captured in the transmission mode when illuminated by a laser light (He-Ne 632.8nm laser). It is well known that the morphological changes occurring during the progression of diseases like cancer manifest in their optical properties which can be probed for differentiating the various stages of cancer. Here, we use the multi-resolution properties of the wavelet transform to analyze the optical changes. For this, we have used a novel laser imagery technique which provides us with a composite image of the absorption by the different cellular organelles. As the disease progresses, due to the growth of new cells, the ratio of the organelle to cellular volume changes manifesting in the laser imagery of such tissues. In order to develop a metric that can quantify the changes in such systems, we make use of the wavelet-based fluctuation analysis. The changing self- similarity during disease progression can be well characterized by the Hurst exponent and the scaling exponent. Due to the use of the Daubechies' family of wavelet kernels, we can extract polynomial trends of different orders, which help us characterize the underlying processes effectively. In this study, we observe that the Hurst exponent decreases as the cancer progresses. This measure could be relatively used to differentiate between different stages of cancer which could lead to the development of a novel non-invasive method for cancer detection and characterization.

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