Ms. Shiho Hakomori Profile

Shiho Hakomori

at Keio Univ

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Publications (3)

Proceedings Article | 20 February 2008 Paper

The vascular response observation by the monitoring of the photosensitizer, oxygen, and blood flow during the high intensity pulsed excitation photodynamic therapy 1h after water-soluble photosensitizer intravenous injection

S. Hakomori, H. Matsuo, T. Arai

Proceedings Volume 6854, 68540Q (2008) https://doi.org/10.1117/12.762057

KEYWORDS: Photodynamic therapy, Oxygen, Blood, Excimers, Dye lasers, Luminescence, Blood circulation, Pulsed laser operation, Tumors, Sodium

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We investigated the correlation between the therapeutic effect by early irradiation Photodynamic Therapy (PDT) and vascular response. The early irradiation PDT has been proposed by our group. This PDT protocol is that pulse laser irradiates to tumors 1 h after intravenous injection of water-soluble photosensitizer. The intact layer appeared over the well treated layer, when the early irradiation PDT was performed at rat prostate subcutaneous tumors with high intensity pulse laser (over 1 MW/cm² in peak intensity) and Talaporfin sodium. In order to clarify the phenomenon mechanism, we monitored blood volume, surface temperature, photosensitizer amount, and oxygen saturation during the PDT. The rat prostate subcutaneous tumor was irradiated with excimer dye laser light at 1 h after the intravenous injection. The photosensitizer dose wa 2.0 mg/kg, and the pulse energy density was 2.5 mJ/cm² (low intensity) or 10 mJ/cm² (high intensity). Under the low intensity pulsed PDT, the fluorescence amount was decreasing gently during the irradiation, and the blood volume and oxygen saturation started decreasing just after the irradiation. Under the hgh intensity pulsed PDT, the fluorescence amount was decreaased rapidly for 20 s after the irradiation started. The blood volume and oxygen saturation were temporally decreased during the irradiation, and recovered at 48 hrs after the irradiation. According to these results, under the low intensity pulsed PDT, the blood vessel located near the surface started closing just after the irradiation. On the other hand, under the high intensity pulsed PDT the blood vessel was closing for 20 s after the irradiation started, moreover, the blood flow recovered at 48 hrs after the irradiation. We concluded that the vascular response depended on the pulse energy density, and then the therapeutic effect was attributed to the difference of the vascular response. In other words, the surface intact layer could be considered to be induced the temporal drug and oxygen depletion effect associated with the temporal vascular shutdown.

Proceedings Article | 20 February 2008 Paper

The mechanism of PDT-induced electrical blockade: the measurement of intracellular Ca 2+ concentration changes in cardiac myocytes

A. Ito, S. Hosokawa, S. Hakomori, S. Miyoshi, K. Soejima, T. Arai

Proceedings Volume 6854, 68540M (2008) https://doi.org/10.1117/12.762058

KEYWORDS: Photodynamic therapy, Luminescence, Sodium, Calcium, Atrial fibrillation, Tissues, Picosecond phenomena, Semiconductor lasers, Tissue optics, Cancer

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Proceedings Article | 28 February 2007 Paper

The measurement of the phosphorescence and singlet oxygen fluorescence time-resolved waveforms of Photofrin(II) and Talaporfin sodium with pulsed excitation

Shiho Hakomori, Sayaka Ohmori, Kensuke Masuda, Kojiro Yamamoto, Tsunenori Arai

Proceedings Volume 6427, 642715 (2007) https://doi.org/10.1117/12.699857

KEYWORDS: Phosphorescence, Luminescence, Sodium, Photodynamic therapy, Oxygen, Photonics, Camera shutters, Excimer lasers, Dye lasers, Quantum efficiency

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