Measurement of tissue optical properties with optical coherence tomography (OCT) shows that scattering coefficient
has an effect on the OCT signal slope. The slope is calculated by linear fitting with a certain range of OCT
signal; hence, the effect of fitting range on the scattering induced change of slope is an important topic. In this
paper, we study the scattering induced change of OCT signal slope versus depth in Intralipid suspensions with
different concentrations based on Monte Carlo simulation. The results show that the OCT signal slope expresses
a contrary change with scattering coefficient below a certain depth in high Intralipid concentrations, so there is
an effective fitting depth. The effective fitting depth is approximately 600 μm for 10% Intralipid and increases
with decreasing concentrations. The effective fitting depth is due to the face that multiple scattering photons of
backscattered light become dominant below the depth, and it is related with the numeric aperture (NA) of the
object lens.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.