Dr. Shuai Lian Profile

Dr. Shuai Lian

at Changchun Univ of Science and Technology

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 20 December 2019 Paper

Raman spectral properties of Fenbendazole molecules

Shuai Lian, Jiahe Liu, Jiazhe Lu, Yifan Gu, Xun Gao, Chao Song

Proceedings Volume 11209, 112090H (2019) https://doi.org/10.1117/12.2542644

KEYWORDS: Raman spectroscopy, Gold, Molecules, Liquids, Molecular spectroscopy, Laser applications, Chromatography, Quantitative analysis, Spectroscopy, Testing and analysis

Read Abstract +

Fenbendazole is one kind of benzimidazole derivatives which is widely used in the treatment of parasitic infections. Because the drug action mechanism of fenbendazole is consistent with many anticancer drugs and the price is cheaper, it is considered as a potential new anticancer drug, which has caused extensive research attention. Traditional fenbendazole research methods are mostly chemical methods such as liquid chromatography. Although these methods have high precision, they have the disadvantages of cumbersome steps, high cost, and the need for specialized technicians to operate. The research method of molecular vibration information of fenbendazole has not been reported yet. In this paper, the density function theory B3LYP/6-31G* basis set and the pseudopotential basis set Lanl2dz were used to optimize and calculate the Raman activity spectrum of fenbendazole and the theoretical enhanced activity spectrum of Au as the substrate. The characteristic peaks of fenbendazole at 1093cm^-1 , 1453cm^-1 , 1534cm^-1 , and 1633cm^-1 were significantly enhanced. These characteristic peaks can be used for qualitative and quantitative analysis of fenbendazole. The causes of the difference between the theoretically calculated Raman activity spectrum and the experimental Raman spectrum are analyzed. The enhancement principle of Raman activity spectrum with Au substrate was also described. The research results will provide theoretical support for the study of the molecular properties of fenbendazole.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years