The purpose of the present study was to evaluate toxicological properties and photodynamic activity of a new ready form
of the photosensitizer Photolon (Fotolon) - an ointment for topical use. The data obtained show the use of topicaly
applied photosensitizer provides sufficient penetration and accumulation of the active compound in tumor tissue as well
as in affected periodontal tissues for the effective PDT. There are several advantages of PDT with topical application of
the photosensitizer such as absence of systemic toxic and photosensitive reactions, relatively low cost of the treatment
and etc. We have shown that PDT of affected periodontal tissues with local application of Photolon/Fotolon ointment
provides an ability of local destruction of microbial cell, located as on the gum surface as in the spatium intercellulare
what is extremely important for successful treatment of acute and chronic periodontitis.
The purpose of the present study was to summarize data on the long-term efficacy of photodynamic therapy (PDT) with
Photolon in patients with malignant tumors of various types and localizations. The data obtained show that PDT with
Photolon is a highly effective therapeutic modality for the treatment of skin tumors, cervical intraepithelial neoplasias,
lung cancers, disseminated forms of melanoma, primary and metastatic brain tumors, several ophthalmologic diseases.
This paper provides a review of most illustrative studies of the application of PDT with Photolon for the treatment of
different oncological and non-oncological diseases performed in leading clinical centers of the Republic of Belarus and