Dr. Srivalleesha Mallidi Profile

Dr. Srivalleesha Mallidi

Assistant Professor at Tufts Univ

SPIE Involvement:

Conference Program Committee | Author

Publications (58)

Proceedings Article | 19 March 2024 Presentation

Presentation

Real-time photodynamic therapy monitoring with ultrasound-guided photoacoustic imaging

Andrew Langley, Allison Sweeney, Brooke Bednarke, Faizah Wulandana, Srivalleesha Mallidi

Proceedings Volume PC12823, PC128230E (2024) https://doi.org/10.1117/12.3003211

KEYWORDS: Photodynamic therapy, Photoacoustic imaging, Oxygen, Optical sensing, Tumors, Transducers, Therapeutics, Systems modeling, Oxygenation, Optical fibers

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Proceedings Article | 13 March 2024 Presentation

Presentation

Molecular imaging and photoimmunotherapy of oral cancers using an EGFR targeted antibody conjugate

Mohammad Saad, Harrison Roberts, Isabella Feng, Kaylee Mai, Zhiming Mai, Srivalleesha Mallidi, Tayyaba Hasan

Proceedings Volume PC12818, (2024) https://doi.org/10.1117/12.3000573

KEYWORDS: Tumors, Antibodies, Cancer, Photoimmunotherapy, Molecular imaging, Resection, Dyes, Surgery, Fluorescence, Diseases and disorders

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Proceedings Article | 13 March 2024 Presentation

Presentation

Quantitative ultrasound and photoacoustic imaging to monitor photodynamic therapy outcomes

Skye Edwards, Srivalleesha Mallidi

Proceedings Volume PC12823, PC128230C (2024) https://doi.org/10.1117/12.3003464

KEYWORDS: Ultrasonography, Photodynamic therapy, Photoacoustic imaging, Tumors, Photoacoustic spectroscopy, Pancreatic cancer, Structural monitoring, Radiomics, Oxygen, Oncology

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Proceedings Article | 13 March 2024 Presentation

Presentation

Photoacoustic annotation toolkit for MATLAB (PHANTOM)

Allison Sweeney, Skye Edwards, Srivalleesha Mallidi

Proceedings Volume PC12842, PC128421C (2024) https://doi.org/10.1117/12.3003278

KEYWORDS: Photoacoustic spectroscopy, MATLAB, Process modeling, Tissues, Monte Carlo methods, Imaging systems, Image segmentation, Visualization, Visual process modeling, Ultrasonography

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Proceedings Article | 13 March 2024 Presentation

Presentation

Eutectic gallium-indium alloy-based liquid metal nanoparticles for biomedical imaging and photodynamic therapy

Marvin Xavierselvan, Sumeyra Gokalp, Sabrina Hafiz, Michelle Foster, Srivalleesha Mallidi

Proceedings Volume PC12859, PC1285906 (2024) https://doi.org/10.1117/12.3003286

KEYWORDS: Nanoparticles, Photodynamic therapy, Metals, Liquids, Biomedical optics, Alloys, Contrast agents, Photosensitizer targeting, Photoacoustic imaging, Passivation

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Proceedings Article | 13 March 2024 Presentation

Presentation

Enhancing efficacy in hypoxic HNC spheroids with PDT-based combinatorial treatments

Marvin Xavierselvan, Vicky Yang, Srivalleesha Mallidi

Proceedings Volume PC12823, PC128230B (2024) https://doi.org/10.1117/12.3003300

KEYWORDS: Photodynamic therapy, Tumors, 3D modeling, Hypoxia, Toxicity, Oxygenation, Neck, Head, Control systems, Cancer

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Proceedings Article | 13 March 2024 Presentation

Presentation

Ultrasound-guided photoacoustic functional imaging to assess regional response to receptor tyrosine kinase inhibitor therapies

Srivalleesha Mallidi, Allison Sweeney, Andrew Langley, Patrick Solomon

Proceedings Volume PC12834, PC1283408 (2024) https://doi.org/10.1117/12.3003456

KEYWORDS: Tumors, Therapeutics, Photoacoustic spectroscopy, Pancreatic cancer, Functional imaging, Image segmentation, Oxygenation, Solids, Radiography, Photoacoustic imaging

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Proceedings Article | 13 March 2024 Presentation

Presentation

Distinguishing ectopic placental calcification with multi-parametric ultrasound and photoacoustic imaging

Skye Edwards, Ana Correia-Branco, Deeksha Sankepalle, Allison Sweeney, Patrick Solomon, Mary Wallingford, Srivalleesha Mallidi

Proceedings Volume PC12827, PC1282707 (2024) https://doi.org/10.1117/12.3003133

KEYWORDS: Multimodal imaging, Tissues, Ultrasonography, Photoacoustic imaging, Vascular diseases, Statistical analysis, Risk assessment, Photoacoustic spectroscopy, Oxygen, Minerals

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Proceedings Article | 13 March 2024 Presentation

Presentation

Perfluorocarbon nanodroplets for photoacoustic image-guided oxygen-enhanced photodynamic therapy of hypoxic tumors

Marvin Xavierselvan, Jason Cook, Srivalleesha Mallidi

Proceedings Volume PC12862, PC128620G (2024) https://doi.org/10.1117/12.3003272

KEYWORDS: Tumors, Nanodroplets, Photodynamic therapy, Oxygen, Photoacoustic spectroscopy, Hypoxia, Solids, In vivo imaging, Resistance, Real time imaging

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Proceedings Article | 12 March 2024 Presentation + Paper

Presentation + Paper

Enhancement of signal-to-noise ratio for real-time LED-based photoacoustic imaging systems using denoising cycle-consistent generative adversarial networks

Avijit Paul, Srivalleesha Mallidi

Proceedings Volume 12842, 128420F (2024) https://doi.org/10.1117/12.3003312

KEYWORDS: Signal to noise ratio, Denoising, Gallium nitride, Education and training, Image quality, Tumors, Graphite, Deep learning, Photoacoustic spectroscopy, Tunable filters

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SPIE Journal Paper | 21 July 2023 Open Access

Open Access

Clinical assessment of a low-cost, hand-held, smartphone-attached intraoral imaging probe for 5-aminolevulinic acid photodynamic therapy monitoring and guidance

Shakir Khan, Bofan Song, Srivalleesha Mallidi, Shaobai Li, Hui Liu, M. A. Bilal Hussain, Shaista Siddiqui, Amjad P. Khan, Kafil Akhtar, Shahid Ali Siddiqui, Syed Abrar Hasan, Colin Hopper, Stephen G. Bown, Rongguang Liang, Tayyaba Hasan, Jonathan P. Celli

JBO, Vol. 28, Issue 08, 082809, (July 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.8.082809

KEYWORDS: Photodynamic therapy, Tissues, Image segmentation, Cancer, Oncology, Biomedical optics, Tumors, Imaging systems, Light emitting diodes, Collagen

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SignificanceIndia has one of the highest rates of oral squamous cell carcinoma (OSCC) in the world, with an incidence of 15 per 100,000 and more than 70,000 deaths per year. The problem is exacerbated by a lack of medical infrastructure and routine screening, especially in rural areas. New technologies for oral cancer detection and timely treatment at the point of care are urgently needed.AimOur study aimed to use a hand-held smartphone-coupled intraoral imaging device, previously investigated for autofluorescence (auto-FL) diagnostics adapted here for treatment guidance and monitoring photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence (FL).ApproachA total of 12 patients with 14 buccal mucosal lesions having moderately/well-differentiated micro-invasive OSCC lesions (<2 cm diameter and <5 mm depth) were systemically (in oral solution) administered three doses of 20 mg / kg ALA (total 60 mg / kg). Lesion site PpIX and auto-FL were imaged using the multichannel FL and polarized white-light oral cancer imaging probe before/after ALA administration and after light delivery (fractionated, total 100 J / cm2 of 635 nm red LED light).ResultsThe handheld device was conducive for access to lesion site images in the oral cavity. Segmentation of ratiometric images in which PpIX FL is mapped relative to auto-FL enabled improved demarcation of lesion boundaries relative to PpIX alone. A relative FL (R-value) threshold of 1.4 was found to segment lesion site PpIX production among the patients with mild to severe dysplasia malignancy. The segmented lesion size is well correlated with ultrasound findings. Lesions for which R-value was >1.65 at the time of treatment were associated with successful outcomes.ConclusionThese results indicate the utility of a low-cost, handheld intraoral imaging probe for image-guided PDT and treatment monitoring while also laying the groundwork for an integrated approach, combining cancer screening and treatment with the same hardware.

Proceedings Article | 9 March 2023 Presentation

Presentation

Biodegradable silk as an ultrasound and photoacoustic phantom material

Christopher Nguyen, Skye Edwards, Tyler Iorizzo, Brooke Longo, David Kaplan, Srivalleesha Mallidi

Proceedings Volume PC12379, PC123790L (2023) https://doi.org/10.1117/12.2650641

KEYWORDS: Ultrasonography, Photoacoustic spectroscopy, Tissues, Tissue optics, Acoustics, Scattering, Polymers, Absorption, Signal attenuation, Scatter measurement

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Proceedings Article | 9 March 2023 Presentation

Presentation

Distinguishing ectopic placental calcification with multi-parametric ultrasound and photoacoustic imaging

Skye Edwards, Deeksha Sankepalle, Ana Branco, Mary Wallingford, Srivalleesha Mallidi

Proceedings Volume PC12379, PC1237918 (2023) https://doi.org/10.1117/12.2650611

KEYWORDS: Ultrasonography, Photoacoustic imaging, Tissues, Vascular diseases, Oxygen, Mouse models, Minerals, In vivo imaging, Imaging systems, Fetus

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Proceedings Article | 9 March 2023 Presentation

Presentation

In-vivo demonstration and validation of U-net based real-time photoacoustic imaging with LED arrays

Avijit Paul, Allison Sweeney, Christopher Nguyen, Srivalleesha Mallidi

Proceedings Volume PC12379, PC1237919 (2023) https://doi.org/10.1117/12.2650767

KEYWORDS: Light emitting diodes, Signal to noise ratio, In vivo imaging, Photoacoustic imaging, Imaging systems, Imaging arrays, Image quality, Image resolution, Signal generators, Real time imaging

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Proceedings Article | 9 March 2022 Presentation + Paper

Presentation + Paper

EGFR-targeted multi-modal molecular imaging and treatment in a heterocellular model of head and neck cancer

Mohammad Saad, Leslie Contreras, Shazia Bano, Scott Selfridge, Zhiming Mai, Robert Pawle, Mark Varvares, Srivalleesha Mallidi, Tayyaba Hasan

Proceedings Volume 11935, 1193507 (2022) https://doi.org/10.1117/12.2610047

KEYWORDS: Tumors, Luminescence, Cancer, Neck, Head, Surgery, Tissues, Tissue optics, Photoacoustic spectroscopy, Photoimmunotherapy, Photodynamic therapy, Molecular imaging

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Proceedings Article | 7 March 2022 Poster + Presentation

Poster + Presentation

Collagen detection in silk protein-based scaffolds through ultrasound and photoacoustic imaging

Christopher Nguyen, Sara Rudolph, David Kaplan, Srivalleesha Mallidi

Proceedings Volume PC11960, PC119601J (2022) https://doi.org/10.1117/12.2610402

KEYWORDS: Collagen, Ultrasonography, Photoacoustic imaging, Photoacoustic spectroscopy, Tissues, Tissue optics, Ultrasonics, Tissue engineering, Spectroscopy, Microscopy

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Proceedings Article | 7 March 2022 Presentation

Presentation

Eutectic gallium-indium alloy based liquid metal nanoparticles for photoacoustic imaging and photodynamic therapy

Marvin Xavierselvan, Sumeyra Gokalp, Sabrina Hafiz, Michelle Foster, Srivalleesha Mallidi

Proceedings Volume PC11940, (2022) https://doi.org/10.1117/12.2609234

KEYWORDS: Nanoparticles, Photodynamic therapy, Metals, Liquids, Photoacoustic imaging, Oxides, Tumors, Photosensitizer targeting, Oxygen, Medical imaging

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Proceedings Article | 7 March 2022 Presentation

Presentation

Photoacoustic image guided oxygen enhanced photodynamic therapy of hypoxic tumors

Marvin Xavierselvan, Jason Cook, Jeanne Duong, Nashielli Diaz, Kimberly Homan, Srivalleesha Mallidi

Proceedings Volume PC11960, PC119600F (2022) https://doi.org/10.1117/12.2609230

KEYWORDS: Oxygen, Tumors, Photodynamic therapy, Nanodroplets, Image enhancement, Photoacoustic spectroscopy, Hypoxia, Solids, In vivo imaging, Real time imaging

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Proceedings Article | 7 March 2022 Presentation

Presentation

3D ultrasound guided-photoacoustic vascular imaging of pancreatic tumors to predict response to tyrosine kinase inhibitor therapy

Abigail Claus, Allison Sweeney, Brian Li, Daniel Wong, Callie Watson, Deeksha Sankepalle, Marvin Xavierselvan, Srivalleesha Mallidi

Proceedings Volume PC11960, PC119600E (2022) https://doi.org/10.1117/12.2609062

KEYWORDS: Tumors, 3D image processing, Ultrasonography, Vascular imaging, Photoacoustic imaging, Pancreatic cancer, Oxygen, Visualization, Tumor growth modeling, Transducers

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Proceedings Article | 4 March 2022 Presentation + Paper

Presentation + Paper

Clinical assessment of a low-cost, hand-held, smartphone-attached intraoral imaging probe for ALA PDT monitoring and guidance

Shakir Khan, Bofan Song, Srivalleesha Mallidi, Shaobai Li, Hui Liu, M. A. Bilal Hussain, Mayra BaptistaLopesTeix, Shaista Siddiqui, Amjad Khan, Kafil Akhtar, Shahid Ali Siddiqui, Syed Abrar Hasan, Colin Hopper, Stephen Bown, Rongguang Liang, Tayyaba Hasan, Jonathan Celli

Proceedings Volume 11940, 1194004 (2022) https://doi.org/10.1117/12.2609956

KEYWORDS: Photodynamic therapy, Cancer, Image segmentation, Tissues, Oncology, Light emitting diodes, Imaging systems, Visualization

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Proceedings Article | 7 December 2021 Paper

Paper

Fluorescence and optoacoustics monitoring of tumor treatment with novel agents for combined photodynamic and chemotherapy

I. Turchin, M. Kirillin, A. Orlova, V. Perekatova, V. Plekhanov, E. Sergeeva, D. Kurakina, A. Khilov, A. Kurnikov, P. Subochev, M. Shirmanova, A. Komarova, D. Yuzhakova, A. Gavrina, S. Bano, S. Mallidi, T. Hasan

Proceedings Volume 11919, 119191J (2021) https://doi.org/10.1117/12.2614869

KEYWORDS: Tumors, Photodynamic therapy, Luminescence, Optoacoustics, IRIS Consortium, Tissues, Picosecond phenomena, Laser irradiation, Cancer, Reconstruction algorithms

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Proceedings Article | 6 March 2021 Poster + Presentation

Poster + Presentation

Modular and flexible 3D printed holder for deep tissue imaging with LED array based photoacoustic imaging

Maju Kuriakose, Christopher Nguyen, Mithun Kuniyil Ajith Singh, Srivalleesha Mallidi

Proceedings Volume 11642, 1164244 (2021) https://doi.org/10.1117/12.2579080

KEYWORDS: Light emitting diodes, Photoacoustic imaging, 3D image processing, Imaging arrays, Deep tissue imaging, Tissue optics, Ultrasonography, Tumors, Switches, Signal to noise ratio

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Proceedings Article | 6 March 2021 Poster + Presentation

Poster + Presentation

Can photoacoustic imaging to predict cellular photodynamic therapy efficacy?

Srivalleesha Mallidi, Marvin Xavierselvan, Zhiming Mai, Tayyaba Hasan

Proceedings Volume 11642, 116424F (2021) https://doi.org/10.1117/12.2579029

KEYWORDS: Photodynamic therapy, Photoacoustic imaging, Oxygen, Tumors, Picosecond phenomena, Photochemistry, Mouse models, Luminescence

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Proceedings Article | 5 March 2021 Presentation

Presentation

Photoacoustic nanodroplets for oxygen enhanced photodynamic therapy

Marvin Xavierselvan, Jason Cook, Kimberly Homan, Srivalleesha Mallidi

Proceedings Volume 11628, 116280E (2021) https://doi.org/10.1117/12.2579063

KEYWORDS: Photodynamic therapy, Picosecond phenomena, Nanoparticles, Nanodroplets, Photoacoustic spectroscopy, Cancer, Absorption, Tumors, Receptors, Phototherapy

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Proceedings Article | 5 March 2021 Presentation

Presentation

Preclinical cancer imaging using a multispectral LED-based photoacoustic and ultrasound imaging system

Marvin Xavierselvan, Mithun Kuniyil Ajith Singh, Srivalleesha Mallidi

Proceedings Volume 11642, 116422G (2021) https://doi.org/10.1117/12.2579263

KEYWORDS: Imaging systems, Multispectral imaging, Ultrasonography, Photoacoustic imaging, Tumors, Cancer, Preclinical imaging, Laser systems engineering, Signal to noise ratio, Photoacoustic spectroscopy

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Proceedings Article | 5 March 2021 Presentation

Presentation

Effective combinatorial therapy design with multi-wavelength photoacoustic imaging

Srivalleesha Mallidi

Proceedings Volume 11622, 116220F (2021) https://doi.org/10.1117/12.2590877

SPIE Journal Paper | 30 June 2020 Open Access

Open Access

Mutual impact of clinically translatable near-infrared dyes on photoacoustic image contrast and in vitro photodynamic therapy efficacy (Erratum)

Ljubica Petrovic, Marvin Xavierselvan, Maju Kuriakose, Michael Kennedy, Christopher Nguyen, Julian Batt, Kelsey Detels, Srivalleesha Mallidi

JBO, Vol. 25, Issue 06, 069802, (June 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.6.069802

KEYWORDS: Photodynamic therapy, Photoacoustic spectroscopy, In vitro testing, Biomedical engineering, Absorbance

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SPIE Journal Paper | 11 April 2020 Open Access

Open Access

Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA-PDT treatment of early oral cancer

Shakir Khan, M. A. Bilal Hussain, Amjad Khan, Hui Liu, Shaista Siddiqui, Srivalleesha Mallidi, Paola Alacron, Liam Daly, Grant Rudd, Filip Cuckov, Colin Hopper, Stephen Bown, Kafil Akhtar, Syed Abrar Hasan, Shahid Ali Siddiqui, Tayyaba Hasan, Jonathan Celli

JBO, Vol. 25, Issue 06, 063813, (April 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.6.063813

KEYWORDS: Luminescence, Image segmentation, Photodynamic therapy, RGB color model, Cancer, Oncology, Imaging devices, Image analysis, Statistical analysis, Phototherapy

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Significance: India has one of the highest rates of oral cancer incidence in the world, accounting for 30% of reported cancers. In rural areas, a lack of adequate medical infrastructure contributes to unchecked disease progression and dismal mortality rates. Photodynamic therapy (PDT) has emerged as an effective modality with potential for treating early stage disease in resource-limited settings, while photosensitizer fluorescence can be leveraged for treatment guidance. Aim: Our aim was to assess the capability of a simple smartphone-based device for imaging 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence for treatment guidance and monitoring as part of an ongoing clinical study evaluating low-cost technology for ALA-based PDT treatment of early oral cancer. Approach: A total of 29 subjects with <2 cm diameter moderately/well-differentiated microinvasive ( < 5 mm depth) oral squamous cell carcinoma lesions (33 lesions total, mean area ∼1.23 cm2) were administered 60 mg / kg ALA in oral solution and imaged before and after delivery of 100 J / cm2 total light dose to the lesion surface. Smartphone-based fluorescence and white light (WL) images were analyzed and compared with ultrasound (US) imaging of the same lesions. Results: We present a comparative analysis of pre- and post-treatment fluorescence, WL, and US images of oral lesions. There was no significant difference in the distribution of lesion widths measured by fluorescence and US (mean widths of 14.5 and 15.3 mm, respectively) and linear regression shows good agreement (R2 = 0.91). In general, PpIX fluorescence images obtained prior to therapeutic light delivery are able to resolve lesion margins while dramatic photobleaching (∼42 % ) is visible post-treatment. Segmentation of the photobleached area confirms the boundaries of the irradiated zone. Conclusions: A simple smartphone-based approach for imaging oral lesions is shown to agree in most cases with US, suggesting that this approach may be a useful tool to aid in PDT treatment guidance and monitoring photobleaching as part of a low-cost platform for intraoral PDT.

SPIE Journal Paper | 28 February 2020 Open Access

Open Access

Mutual impact of clinically translatable near-infrared dyes on photoacoustic image contrast and in vitro photodynamic therapy efficacy

Ljubica Petrovic, Marvin Xavierselvan, Maju Kuriakose, Michael Kennedy, Christopher Nguyen, Julian Batt, Kelsey Detels, Srivalleesha Mallidi

JBO, Vol. 25, Issue 06, 063808, (February 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.6.063808

KEYWORDS: Photodynamic therapy, Pulsed laser operation, Absorption, Continuous wave operation, Picosecond phenomena, Photoacoustic spectroscopy, Cancer, Absorbance, Oxygen, Tissue optics

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Proceedings Article | 24 February 2020 Presentation + Paper

Presentation + Paper

Imaging tumor vasculature using LED based photoacoustic system

Marvin Xavierselvan, Mithun Kuniyil Ajith Singh, Srivalleesha Mallidi

Proceedings Volume 11240, 112400R (2020) https://doi.org/10.1117/12.2546837

KEYWORDS: Tumors, Light emitting diodes, Photoacoustic spectroscopy, Imaging systems, 3D image reconstruction, Photoacoustic imaging

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Proceedings Article | 19 February 2020 Paper

Paper

Combined fluorescence and optoacoustic imaging for monitoring the efficiency of photodynamic therapy with BPD-based nanoconstructs

I. Turchin, M. Kirillin, D. Kurakina, A. Orlova, V. Plekhanov, E. Sergeeva, P. Subochev, E. Sergeev, V. Perekatova, A. Nerush, D. Yuzhakova, E. Kiseleva, M. Shirmanova, S. Bano, S. Mallidi, T. Hasan

Proceedings Volume 11220, 112200V (2020) https://doi.org/10.1117/12.2565087

KEYWORDS: Tumors, Photodynamic therapy, Luminescence, Tissues, Optoacoustics, Visualization, Imaging systems, Absorption, Pulsed laser operation, Blood

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Proceedings Article | 17 February 2020 Presentation + Paper

Presentation + Paper

LED-based photoacoustic imaging for early detection of joint inflammation in rodents: towards achieving 3Rs in rheumatoid arthritis research

Francis Kalloor Joseph, Marvin Xavierselvan, Mithun Kuniyil Ajith Singh, Srivalleesha Mallidi, Conny van der Laken, Fons van de Loo, Wiendelt Steenbergen

Proceedings Volume 11240, 112400M (2020) https://doi.org/10.1117/12.2545915

KEYWORDS: Oxygen, Imaging systems, Arthritis, Blood, Photoacoustic imaging, Hypoxia, Animal model studies, In vivo imaging, Inflammation, Image resolution

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Proceedings Article | 14 August 2019 Presentation

Presentation

Dual function antibody conjugates (DFACs) for drug quantification and therapy (Conference Presentation)

Mohammad Saad, Marvin Xavierselvan, Hamza Sharif, Srivalleesha Mallidi, Tayyaba Hasan

Proceedings Volume 11070, 1107011 (2019) https://doi.org/10.1117/12.2528162

KEYWORDS: Photoacoustic spectroscopy, Luminescence, Tissue optics, Imaging technologies, Ultrasonography, Optical coherence tomography, Magnetic resonance imaging, Computed tomography, Diagnostics, Tomography

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Proceedings Article | 14 August 2019 Presentation

Presentation

Design and evaluation of applicators for photodynamic therapy of oral cavity tumors in low resource settings (Conference Presentation)

Amjad P. Khan, Srivalleesha Mallidi, Hui Liu, Liam Daly, Grant Rudd, M. A. Bilal Hussain, Shakir Khan, Shahid A. Siddiqui, Syed A. Hasan, Kafil Akhtar, Shaista Siddiqui, Meredith August, Maria Troulis, Filip Cuckov, Jonathan P. Celli, Tayyaba Hasan

Proceedings Volume 11070, 11070BH (2019) https://doi.org/10.1117/12.2525860

KEYWORDS: Photodynamic therapy, Cancer, Tumors, Therapeutics, Surgery, Oncology, Phototherapy, Biochemistry, Light sources, 3D acquisition

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Proceedings Article | 14 August 2019 Presentation

Presentation

Interpretation of ultrasonography indicators of photodynamic therapy treatment response in early malignancy of buccal mucosa (Conference Presentation)

Shaista Siddiqui, Ibne Ahmed, Kafil Akhtar, Shahid Ali Siddiqui, M. A. Bilal Hussain, Shakir Khan, Srivalleesha Mallidi, Amjad P. Khan, Hui Liu, Filip Cuckov, Grant Rudd, Liam Daly, Colin Hopper, Stephen G. Bown, Satish C. Sharma, Syed Abrar Hasan, Jonathan P. Celli, Tayyaba Hasan, Paola Leon

Proceedings Volume 11070, 110703Y (2019) https://doi.org/10.1117/12.2525982

KEYWORDS: Photodynamic therapy, Ultrasonography, Biopsy, Cancer, Biological research, Light emitting diodes, Light sources, Inflammation

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Proceedings Article | 14 August 2019 Presentation

Presentation

Photodynamic therapy as an alternative treatment modality for early stage buccal mucosa malignancy (Conference Presentation)

Shahid Ali Siddiqui, M. A. Bilal Hussain, Amjad P. Khan, Kafil Akhtar, Shaista Siddiqui, Shakir Khan, Hui Liu, Srivalleesha Mallidi, Grant Rudd, Liam Daly, Paola L. Alacron, Filip Cuckov, Satish C. Sharma, Ibne Ahmed, Stephen G. Bown, Colin Hopper, Jonathan P. Celli, Syed Abrar Hasan, Tayyaba Hasan

Proceedings Volume 11070, 1107053 (2019) https://doi.org/10.1117/12.2525686

KEYWORDS: Photodynamic therapy, Cancer, Oncology, Surgery, Radiotherapy, Light emitting diodes, Light sources, 3D image processing, Light, Luminescence

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Proceedings Article | 14 August 2019 Presentation

Presentation

Surgical navigation in oral tongue cancer resections (Conference Presentation)

Mark Varvares, Meredith August, Tayyaba Hasan, Srivalleesha Mallidi

Proceedings Volume 11070, 110703W (2019) https://doi.org/10.1117/12.2528072

KEYWORDS: Tongue, Cancer, Ultrasonography, Tissues, Tumors, Optical inspection, Surgery, Optical imaging, Photodynamic therapy

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Proceedings Article | 12 August 2019 Presentation + Paper

Presentation + Paper

Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA PDT

Shakir Khan, M. A. Bilal Hussain, Amjad Khan, Hui Liu, Shaista Siddiqui, Srivalleesha Mallidi, Paola Leon, Liam Daly, Grant Rudd, Filip Cuckov, Colin Hopper, Stephen Bown, Shahid Siddiqui, Jonathan Celli, Tayyaba Hasan

Proceedings Volume 11070, 1107059 (2019) https://doi.org/10.1117/12.2526116

KEYWORDS: Luminescence, Photodynamic therapy, Cancer, Tissue optics, Image segmentation, Light emitting diodes, Imaging devices, Light, RGB color model, Phototherapy

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Proceedings Article | 22 July 2019 Paper

Paper

Monitoring of photodynamic therapy with target nanoconstructs by fluorescence and optoacoustic imaging: numerical simulations and phantom study

I. Turchin, M. Yu. Kirillin, D. Kurakina, V. Perekatova, A. Orlova, E. Sergeeva, V. Plehanov, A. Khilov, P. Subochev, S. Mallidi, T. Hasan

Proceedings Volume 11079, 110790O (2019) https://doi.org/10.1117/12.2527016

KEYWORDS: Luminescence, Photodynamic therapy, Tumors, Optoacoustics, Numerical simulations, Monte Carlo methods, Absorption, Picosecond phenomena, Brain, Tissues

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Proceedings Article | 7 March 2019 Presentation

Presentation

Targeting drug-resistant glioblastoma stem cells using photodynamic therapy (Conference Presentation)

Bryan Spring, Kohei Watanabe, Megumi Ichikawa, Srivalleesha Mallidi, Tatsuyuki Matsudaira, Dmitriy Timerman, Hiroaki Wakimoto, Tayyaba Hasan

Proceedings Volume 10860, 1086004 (2019) https://doi.org/10.1117/12.2510962

KEYWORDS: Stem cells, Photodynamic therapy, Tumors, Cancer, Tumor growth modeling, Brain, Therapeutics

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Proceedings Article | 14 March 2018 Presentation

Presentation

Multi-parametric Imaging to predict response post surgery and photodynamic therapy in orthotopic gliobastoma models (Conference Presentation)

Srivalleesha Mallidi, Megumi Ichikawa

Proceedings Volume 10476, 104760H (2018) https://doi.org/10.1117/12.2290715

KEYWORDS: Tumors, Photodynamic therapy, Photoacoustic imaging, Ultrasonography, Surgery, Brain, Phototherapy, Visualization, Transducers, Doppler effect

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Glioblastoma (GBM) has less than one-year survival rate due to local recurrence post treatment or growth of “left-over” residual disease post surgical resection. To personalize treatment strategies and reduce the rate of recurrence, it is important to develop imaging based therapeutic strategies and prediction markers to identify GBM recurrence. Given the role of the vasculature in tumor growth and survival, here we utilize multi-parametric ultrasound and photoacoustic imaging to validate if changes in vascular structure and function could be predictive of treatment response in patient- derived orthotopic Glioblastoma xenograft models. Patient-derived GBM cell lines were implanted in the brain of Swiss nu/nu mice. After the tumors reached 2-4 mm in diameter, the mice were divided into 4 groups namely – no treatment, surgical resection, therapy and surgical resection with therapy. Photodynamic therapy (PDT), a light based cytotoxic therapy, with photosensitizer Benzoporphyrin derivative (BPD) or FDA approved chemotherapy temozolomide were administered in the mice. Fujifilm VisualSonics LAZR system with a 20 MHz transducer was used to obtain power Doppler (%vascularity in tumors) and photoacoustic oxygen saturation (StO2) maps of the brain tumors at different time points pre and post treatment. The mice were either euthanized for immunofluorescence to validate the imaging markers or longitudinally monitored for tumor volume until moribund.The no-treatment group or the surgery only group did not have significant changes in vascular density or StO2. We observed a statistically significant decrease in StO2 immediately post BPD-PDT (primarily a vascular therapy) but not with temozolomide (a cellular therapy). Furthermore, we also observed that the sustenance of hypoxia or low StO2 in tumors for 24-72 hours can be a predictive biomarker for tumor recurrence. Overall, these results suggest the utility of ultrasound and photoacoustic imaging in monitoring treatment response and developing treatment prediction strategies for glioblastoma.

Proceedings Article | 26 April 2016 Presentation

Presentation

Mechanistic exploration of a bi-directional PDT-based combination in pancreatic cancer (Conference Presentation)

Huang-Chiao Huang, Srivalleesha Mallidi, Joyce Liu, Chun-Te Chiang, Zhiming Mai, Ruth Goldschmidt, Imran Rizvi, Neema Ebrahim-Zadeh, Tayyaba Hasan

Proceedings Volume 9694, 96940W (2016) https://doi.org/10.1117/12.2217925

KEYWORDS: Photodynamic therapy, Pancreatic cancer, Tumors, Cancer, Oncology, Toxicity, Tumor growth modeling, Current controlled current source

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Proceedings Article | 26 April 2016 Presentation

Presentation

Predicting photodynamic therapy efficacy with photoacoustic imaging (Conference Presentation)

Srivalleesha Mallidi, Zhiming Mai, Amjad Khan, Tayyaba Hasan

Proceedings Volume 9694, 96940A (2016) https://doi.org/10.1117/12.2217889

KEYWORDS: Photodynamic therapy, Photoacoustic imaging, Oxygen, Photochemistry, Picosecond phenomena, Tumors, Imaging systems, Mouse models, Luminescence, Tumor growth modeling

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Proceedings Article | 1 March 2016 Presentation + Paper

Presentation + Paper

Development of low-cost devices for image-guided photodynamic therapy treatment of oral cancer in global health settings

Hui Liu, Grant Rudd, Liam Daly, Joshua Hempstead, Yiran Liu, Amjad Khan, Srivalleesha Mallidi, Richard Thomas, Imran Rizvi, Stephen Arnason, Filip Cuckov, Tayyaba Hasan, Jonathan Celli

Proceedings Volume 9694, 96940C (2016) https://doi.org/10.1117/12.2212918

KEYWORDS: Photodynamic therapy, Cancer, Light emitting diodes, In vitro testing, 3D modeling, Prototyping, Light sources, Tumors, Switches, Lithium

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SPIE Journal Paper | 24 April 2015 Open Access

Open Access

In vivo evaluation of battery-operated light-emitting diode-based photodynamic therapy efficacy using tumor volume and biomarker expression as endpoints

Srivalleesha Mallidi, Zhiming Mai, Imran Rizvi, Joshua Hempstead, Stephen Arnason, Jonathan Celli, Tayyaba Hasan

JBO, Vol. 20, Issue 04, 048003, (April 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.4.048003

KEYWORDS: Tumors, Photodynamic therapy, Light sources, Light emitting diodes, Cancer, In vivo imaging, Tissues, Hypoxia, Luminescence, Laser sources

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SPIE Journal Paper | 6 February 2014 Open Access

Open Access

Photosensitizer fluorescence and singlet oxygen luminescence as dosimetric predictors of topical 5-aminolevulinic acid photodynamic therapy induced clinical erythema

Srivalleesha Mallidi, Sriram Anbil, Seonkyung Lee, Dieter Manstein, Stefan Elrington, Garuna Kositratna, David Schoenfeld, Brian Pogue, Steven Davis, Tayyaba Hasan

JBO, Vol. 19, Issue 02, 028001, (February 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.2.028001

KEYWORDS: Luminescence, Photodynamic therapy, Picosecond phenomena, Oxygen, Skin, Statistical analysis, Photography, Tissue optics, In vivo imaging, Signal detection

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Proceedings Article | 14 March 2013 Paper

Paper

Environmental effects on molecular biomarkers expression in pancreatic and brain cancer

Lawrence Mensah, Srivalleesha Mallidi, Iqbal Massodi, Sriram Anbil, Zhiming Mai, Tayyaba Hasan

Proceedings Volume 8568, 856803 (2013) https://doi.org/10.1117/12.2010697

KEYWORDS: Tumors, Proteins, Cancer, Pancreatic cancer, In vivo imaging, Tissues, In vitro testing, Photodynamic therapy, Photonic integrated circuits, Oncology

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Proceedings Article | 13 March 2013 Paper

Paper

Towards image-guided photodynamic therapy of Glioblastoma

Srivalleesha Mallidi, Huang-Chiao Huang, Joyce Liu, Zhiming Mai, Tayyaba Hasan

Proceedings Volume 8568, 85681C (2013) https://doi.org/10.1117/12.2010684

KEYWORDS: Tumors, Photodynamic therapy, Ultrasonography, Photoacoustic spectroscopy, Brain, Luminescence, Photoacoustic imaging, Tissue optics, Cancer, Oncology

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Proceedings Article | 24 February 2010 Paper

Paper

Combined photoacoustic and magneto-motive ultrasound imaging

Min Qu, Seungsoo Kim, Mohammad Mehrmohammadi, Srivalleesha Mallidi, Pratixa Joshi, Kimberly Homan, Yun-Sheng Chen, Stanislav Emelianov

Proceedings Volume 7564, 756433 (2010) https://doi.org/10.1117/12.842406

KEYWORDS: Ultrasonography, Photoacoustic spectroscopy, Magnetism, Tissue optics, Nanoparticles, Tissues, Transducers, Photoacoustic imaging, Image resolution, Absorption

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Proceedings Article | 24 February 2010 Paper

Paper

Biodegradable plasmonic nanoclusters as contrast agent for photoacoustic imaging

Soon Joon Yoon, Srivalleesha Mallidi, Jasmine Tam, Justina Tam, Avinash Murthy, Pratixa Joshi, Keith Johnston, Konstantin Sokolov, Stanislav Emelianov

Proceedings Volume 7564, 756437 (2010) https://doi.org/10.1117/12.842653

KEYWORDS: Nanoparticles, Photoacoustic imaging, Ultrasonography, Gold, Near infrared, Particles, Imaging systems, Photoacoustic spectroscopy, Plasmonics, Transducers

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Proceedings Article | 4 March 2009 Paper

Paper

Ultrasound and photoacoustic imaging to monitor vascular growth in tissue engineered constructs

Seung Yun Nam, Srivalleesha Mallidi, Ge Zhang, Laura Suggs, Stanislav Emelianov

Proceedings Volume 7179, 71790G (2009) https://doi.org/10.1117/12.812382

KEYWORDS: Ultrasonography, Photoacoustic spectroscopy, Photoacoustic imaging, Transducers, Blood, Absorption, Tissue optics, Blood vessels, 3D image processing, Oxygen

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SPIE Journal Paper | 1 September 2008 Open Access

Open Access

Combined ultrasound and photoacoustic imaging to detect and stage deep vein thrombosis: phantom and ex vivo studies

Andrei Karpiouk, Salavat Aglyamov, Srivalleesha Mallidi, Jignesh Shah, William Scott, Jonathan Rubin, Stanislav Emelianov

JBO, Vol. 13, Issue 05, 054061, (September 2008) https://doi.org/10.1117/12.10.1117/1.2992175

KEYWORDS: Photoacoustic spectroscopy, Ultrasonography, Veins, Blood, Photoacoustic imaging, Absorption, Tissue optics, Signal detection, Transducers, Imaging systems

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Proceedings Article | 11 March 2008 Paper

Paper

Molecular specific photoacoustic imaging with plasmonic nanosensors

Srivalleesha Mallidi, Evgeniya Yantsen, Timothy Larson, Konstantin Sokolov, Stanislav Emelianov

Proceedings Volume 6856, 685616 (2008) https://doi.org/10.1117/12.763903

KEYWORDS: Gold, Nanoparticles, Photoacoustic spectroscopy, Ultrasonography, Photoacoustic imaging, Nanosensors, Tumors, Plasmonics, Pulsed laser operation, Cancer

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Proceedings Article | 28 February 2007 Paper

Paper

Intravascular photoacoustic imaging of atherosclerotic plaques: ex-vivo study using a rabbit model of atherosclerosis

S. Sethuraman, S. Mallidi, S. Aglyamov, J. Amirian, S. Litovsky, R. Smalling, S. Emelianov

Proceedings Volume 6437, 643729 (2007) https://doi.org/10.1117/12.701111

KEYWORDS: Photoacoustic spectroscopy, Intravascular ultrasound, Blood, Arteries, Ultrasonography, Photoacoustic imaging, Tissue optics, Absorption, Collagen, Transducers

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Proceedings Article | 13 February 2007 Paper

Paper

Measurement of blood perfusion using photoacoustic, ultrasound, and strain imaging

Srivalleesha Mallidi, Andrei Karpiouk, Salavat Aglyamov, Shriram Sethuraman, Stanislav Emelianov

Proceedings Volume 6437, 643707 (2007) https://doi.org/10.1117/12.701230

KEYWORDS: Photoacoustic spectroscopy, Ultrasonography, Tissues, Blood, Transducers, Photoacoustic imaging, Blood vessels, Tumors, Doppler tomography, Ultrasonics

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Proceedings Article | 13 February 2007 Paper

Paper

Photoacoustic imaging using array transducer

Suhyun Park, Srivalleesha Mallidi, Andrei Karpiouk, Salavat Aglyamov, Stanislav Emelianov

Proceedings Volume 6437, 643714 (2007) https://doi.org/10.1117/12.704240

KEYWORDS: Ultrasonography, Photoacoustic spectroscopy, Transducers, Photoacoustic imaging, Imaging systems, Tissue optics, Image quality, Imaging arrays, Image restoration, Ultrafast imaging

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Proceedings Article | 16 March 2006 Paper

Paper

Functional and morphological ultrasonic biomicroscopy for tissue engineers

S. Mallidi, S. Aglyamov, A. Karpiouk, S. Park, S. Emelianov

Proceedings Volume 6147, 61470Y (2006) https://doi.org/10.1117/12.661510

KEYWORDS: Tissues, Ultrasonography, Photoacoustic spectroscopy, Ultrasonics, Photoacoustic imaging, Transducers, Tissue optics, Imaging systems, Tissue engineering, Visualization

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Proceedings Article | 16 March 2006 Paper

Paper

Integrated system for ultrasonic, photoacoustic and elasticity imaging

S. Park, J. Shah, S. Aglyamov, A. Karpiouk, S. Mallidi, A. Gopal, H. Moon, X. Zhang, W. Scott, S. Emelianov

Proceedings Volume 6147, 61470H (2006) https://doi.org/10.1117/12.661508

KEYWORDS: Photoacoustic spectroscopy, Ultrasonography, Imaging systems, Photoacoustic imaging, Transducers, Ultrasonics, Tissue optics, Signal detection, Optical spheres, Tumors

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Showing 5 of 58 publications

Conference Committee Involvement (6)

Photons Plus Ultrasound: Imaging and Sensing 2025

26 January 2025 | San Francisco, California, United States

Multiscale Imaging and Spectroscopy VI

25 January 2025 | San Francisco, California, United States

Multiscale Imaging and Spectroscopy V

27 January 2024 | San Francisco, California, United States

Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXX

6 March 2021 | Online Only, California, United States

Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX

1 February 2020 | San Francisco, California, United States

Showing 5 of 6 Conference Committees

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