Prof. Stefan A. Carp Profile

Prof. Stefan A. Carp

Associate Professor of Radiology at Massachusetts General Hospital

SPIE Involvement:

Editorial Board Member: Neurophotonics | Author

Publications (65)

Proceedings Article | 13 March 2024 Presentation

Presentation

A 256-channel SPAD detector for time-gated fNIRS and DCS

Jonathan Richardson, Tom Cheng, George Jordy, Matthew Stamplis, Ana-Maria Mandrila Vaca, Michael Bradshaw, Erik Duerr, Marco Renna, Mitchell Robinson, Stefan Carp, Maria-Angela Franceschini

Proceedings Volume PC12828, PC128280E (2024) https://doi.org/10.1117/12.3003159

KEYWORDS: Readout integrated circuits, Silicon, Near infrared spectroscopy, Windows, Spectroscopy, Photons, Imaging spectroscopy, Functional imaging, Field programmable gate arrays, Brain

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Proceedings Article | 13 March 2024 Presentation

Presentation

FlexNIRS: current applications and latest developments of the open-source wireless wearable oximeter for cerebral health tracking

Marco Renna, Kuan-Cheng Wu, John Sunwoo, Alyssa Martin, Zachary Starkweather, Mitchell Robinson, Nikola Otic, Paul Beach, Mehrdad Dadgostar, Zahra Einalou, Stefan Carp, David Salat, Maria Angela Franceschini

Proceedings Volume PC12850, PC128500C (2024) https://doi.org/10.1117/12.3003292

KEYWORDS: Oximeters, Wireless communications, Wearable devices, Tissues, Spectroscopes, Signal intensity, Sampling rates, Photodiodes, Oxygen, Near infrared spectroscopy

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Proceedings Article | 13 March 2024 Presentation

Presentation

Depth-enhanced diffuse correlation spectroscopy enabled by coherent gain

Mitchell Robinson, Marco Renna, Stefan Carp, Maria Angela Franceschini

Proceedings Volume PC12841, PC128410C (2024) https://doi.org/10.1117/12.3003352

KEYWORDS: Spectroscopy, Blood circulation, Tissues, Signal detection, Laser sources, Scattered light, Photons, Laser interferometry, Tissue optics, Time metrology

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Proceedings Article | 13 March 2024 Presentation

Presentation

Multi-channel, long-wavelength, interferometric diffuse correlation spectroscopy for functional perfusion imaging

Mitchell Robinson, Kevin Mai, Yoonho Oh, Maria Angela Franceschini, Stefan Carp

Proceedings Volume PC12828, PC128280M (2024) https://doi.org/10.1117/12.3003364

KEYWORDS: Spectroscopy, Perfusion imaging, Interferometry, Imaging spectroscopy, Imaging systems, Multichannel imaging systems, Line scan cameras, Light sources and illumination, Quality measurement, Neuroimaging

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Proceedings Article | 13 March 2024 Presentation

Presentation

Fluorescence lifetime imaging for enhanced tumor contrast using exogenous dyes

Anand T, Kumar, Rahul Pal, Thinzar Lwin, Murali Krishnamoorthy, Hannah Collins, Corey Chan, Andrey Prilutskiy, MacLean Nasrallah, Tom Dijkhuis, Stefan Carp, Yin Hung, Peter Sadow, William Faquin, Brian Nahed, Allen Feng, Kevin Emerick, J. Sven Mieog, Alexander Vahrmeijer, Karthik Rajasekaran, John Y. Lee, Kenneth Rankin, Santiago Lozano-Calderon, Mark Varvares, Kenneth Tanabe

Proceedings Volume PC12825, PC128250P (2024) https://doi.org/10.1117/12.3002108

KEYWORDS: Tumors, Tissues, Surgery, Near infrared, Fluorescence lifetime imaging, Fluorescence, Fluorescence intensity, Image-guided intervention, Contrast agents, Biological imaging

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Proceedings Article | 13 March 2024 Presentation

Presentation

Wearable monitoring of water content variation in peripheral edema

So Hyun Chung, Marco Renna, Maria-Angela Franceschini, Stefan Carp

Proceedings Volume PC12838, PC1283802 (2024) https://doi.org/10.1117/12.3001723

KEYWORDS: Water content, Near infrared spectroscopy, Continuous wave operation, Tissues, Simulations, Prototyping, Lymphatic system, Wearable devices, Vascular diseases, Tissue optics

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Proceedings Article | 12 March 2024 Presentation + Paper

Presentation + Paper

Camera selection for speckle contrast optical spectroscopy and validation against diffuse correlation spectroscopy

Tom Cheng, Byungchan Kim, Bernhard Zimmermann, Mitchell Robinson, Marco Renna, Stefan Carp, Maria Angela Franceschini, David Boas, Xiaojun Cheng

Proceedings Volume 12841, 1284105 (2024) https://doi.org/10.1117/12.3000411

KEYWORDS: Diffuse optical spectroscopy, Temperature control, Cerebral blood flow, Fluctuations and noise, Signal intensity, Cameras, Signal to noise ratio, Quantum reading, Speckle, Spectroscopy, Optical spectroscopy, Liquids, Quantum noise, Interference (communication), CMOS cameras

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SPIE Journal Paper | 27 January 2024 Open Access

Open Access

Comparing the performance potential of speckle contrast optical spectroscopy and diffuse correlation spectroscopy for cerebral blood flow monitoring using Monte Carlo simulations in realistic head geometries

Mitchell Robinson, Tom Cheng, Marco Renna, Melissa Wu, Byungchan Kim, Xiaojun Cheng, David Boas, Maria Angela Franceschini, Stefan Carp

NPh, Vol. 11, Issue 01, 015004, (January 2024) https://doi.org/10.1117/12.10.1117/1.NPh.11.1.015004

KEYWORDS: Speckle, Monte Carlo methods, Sensors, Cameras, Pulsed laser operation, Light sources and illumination, Neurophotonics, Tissues, Signal to noise ratio, Cerebral blood flow

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SignificanceThe non-invasive measurement of cerebral blood flow based on diffuse optical techniques has seen increased interest as a research tool for cerebral perfusion monitoring in critical care and functional brain imaging. Diffuse correlation spectroscopy (DCS) and speckle contrast optical spectroscopy (SCOS) are two such techniques that measure complementary aspects of the fluctuating intensity signal, with DCS quantifying the temporal fluctuations of the signal and SCOS quantifying the spatial blurring of a speckle pattern. With the increasing interest in the use of these techniques, a thorough comparison would inform new adopters of the benefits of each technique.AimWe systematically evaluate the performance of DCS and SCOS for the measurement of cerebral blood flow.ApproachMonte Carlo simulations of dynamic light scattering in an MRI-derived head model were performed. For both DCS and SCOS, estimates of sensitivity to cerebral blood flow changes, coefficient of variation of the measured blood flow, and the contrast-to-noise ratio of the measurement to the cerebral perfusion signal were calculated. By varying complementary aspects of data collection between the two methods, we investigated the performance benefits of different measurement strategies, including altering the number of modes per optical detector, the integration time/fitting time of the speckle measurement, and the laser source delivery strategy.ResultsThrough comparison across these metrics with simulated detectors having realistic noise properties, we determine several guiding principles for the optimization of these techniques and report the performance comparison between the two over a range of measurement properties and tissue geometries. We find that SCOS outperforms DCS in terms of contrast-to-noise ratio for the cerebral blood flow signal in the ideal case simulated here but note that SCOS requires careful experimental calibrations to ensure accurate measurements of cerebral blood flow.ConclusionWe provide design principles by which to evaluate the development of DCS and SCOS systems for their use in the measurement of cerebral blood flow.

SPIE Journal Paper | 5 October 2023 Open Access

Open Access

scatterBrains: an open database of human head models and companion optode locations for realistic Monte Carlo photon simulations

Melissa Wu, Roarke Horstmeyer, Stefan Carp

JBO, Vol. 28, Issue 10, 100501, (October 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.10.100501

KEYWORDS: Head, Simulations, Data modeling, Databases, Tissues, Monte Carlo methods, Sensors, Magnetic resonance imaging, Near infrared spectroscopy, Spectroscopy

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SPIE Journal Paper | 6 September 2023 Open Access

Open Access

Enhancing diffuse correlation spectroscopy pulsatile cerebral blood flow signal with near-infrared spectroscopy photoplethysmography

Kuan Cheng Wu, Alyssa Martin, Marco Renna, Mitchell Robinson, Nisan Ozana, Stefan A. Carp, Maria Angela Franceschini

NPh, Vol. 10, Issue 03, 035008, (September 2023) https://doi.org/10.1117/12.10.1117/1.NPh.10.3.035008

KEYWORDS: Near infrared spectroscopy, Signal to noise ratio, Cerebral blood flow, Blood circulation, Spectroscopy, Blood, Oxygenation, Neurophotonics, Resistance, Sampling rates

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Proceedings Article | 15 June 2023 Presentation

Presentation

A 256-channel SPAD detector for time-gated fNIRS and DCS

Jonathan Richardson, Tom Cheng, Marco Renna, George Jordy, Matthew Stamplis, Ana-Maria Mandrilla Vacca, Michael Bradshaw, Eric Ringdahl, Brian Aull, Megan Blackwell, Erik Duerr, Mitchell Robinson, Stefan Carp, Maria-Angelica Franceschini

Proceedings Volume PC12512, PC1251208 (2023) https://doi.org/10.1117/12.2666270

KEYWORDS: Single photon avalanche diodes, Sensors, Readout integrated circuits, Silicon, Spectroscopy, Sensor performance, Photons, Near infrared spectroscopy, Functional imaging, Field programmable gate arrays

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Proceedings Article | 28 March 2023 Open Access

Open Access

Paper

First clinical results of fluorescence lifetime enhanced tumor imaging using exogenous agents (Conference Presentation) (Withdrawal Notice)

Rahul Pal, Thinzar Lwin, Murali Krishnamoorthy, Stefan Carp, Corey Chan, Maclean Nasrallah, John Y. Lee, Yin Hung, Allen Feng, Kenneth Tanabe, Eben Rosenthal, Brian Nahed, Kevin Emerick, Kenneth Rankin, Santiago Lozano-Calderon, Mark Varvares, Anand T. Kumar

Proceedings Volume PC12361, PC123610H (2023) https://doi.org/10.1117/12.2649241

KEYWORDS: Tumors, Fluorescence imaging, Fluorescence, Surgery, Molecules, Molecular photonics, Biomedical applications

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Proceedings Article | 17 March 2023 Presentation

Presentation

Preliminary study of diffuse correlation spectroscopy for longitudinal monitoring of aneurysmal subarachnoid hemorrhage in the neuro-intensive care unit

Minhee Kim, Bryce Carr, David Y. Chung, Joanna Yang, John Sunwoo, Jae Gwan Kim, Maria A. Franceschini, Stefan A. Carp

Proceedings Volume 12364, 123640A (2023) https://doi.org/10.1117/12.2668722

KEYWORDS: Spectroscopy, Cerebral blood flow, Blood pressure, Blood circulation, Motion detection, Heart, Electrocardiography, Brain, Accelerometers

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Proceedings Article | 17 March 2023 Presentation

Presentation

A comparison of brain perfusion sensitivity achievable by diffuse correlation spectroscopy versus speckle contrast optical spectroscopy

Stefan Carp, Michell Robinson, Xiaojun Cheng, David Boas, Maria Franceschini

Proceedings Volume 12364, 1236408 (2023) https://doi.org/10.1117/12.2650873

KEYWORDS: Speckle, Brain, Spectroscopy, Optical spectroscopy, Signal to noise ratio, Tissue optics, Skull, Monte Carlo methods, Laser speckle contrast imaging, Human subjects

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Proceedings Article | 17 March 2023 Presentation

Presentation

Comparing methodologies for assessing autoregulation in a pediatric swine model using non-invasive optical measurements

Bryce Carr, Kichang Lee, Ekaterina Creed, Dibbyan Mazumder, Behzad Khajavi, Kitae Jung, Michael Silverman, Stefan Carp

Proceedings Volume 12364, 123640M (2023) https://doi.org/10.1117/12.2651036

KEYWORDS: Optical testing, Wavelets, Brain mapping, Brain, Blood pressure, Traumatic brain injury, Near infrared spectroscopy, Hemodynamics, Doppler effect, Cerebral blood flow

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Proceedings Article | 17 March 2023 Presentation

Presentation

Non-invasive monitoring of cerebral hemodynamics using near-infrared spectroscopy and diffuse correlation spectroscopy during transcatheter aortic valve replacement surgery

Ailis Muldoon, Bryce Carr, Behzad Khajavi, Alyssa Martin, Mitchell Robinson, Julia Bertsch, Alexis Novak, Liza Parab, Ariel Mueller, Marissa Albanese, Jason Qu, Maria Angela Franceschini, Stefan Carp

Proceedings Volume 12364, 123640F (2023) https://doi.org/10.1117/12.2668694

KEYWORDS: Near infrared spectroscopy, Surgery, Hemodynamics, Spectroscopy, Oxygen, Injuries, Head, Electroencephalography, Doppler effect, Brain

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Proceedings Article | 7 March 2023 Presentation

Presentation

Early prediction of neoadjuvant chemotherapy outcome with longitudinal breast diffuse optical tomography

Bin Deng, Ailis Muldoon, Jayne Cormier, Mansi Saksena, Steven Isakoff, Stefan Carp

Proceedings Volume PC12376, PC123760J (2023) https://doi.org/10.1117/12.2650855

KEYWORDS: Tumors, Breast, Diffuse optical tomography, Tissues, Imaging systems, Digital breast tomosynthesis, X-rays, X-ray imaging, Tissue optics, Optical imaging

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Proceedings Article | 7 March 2023 Presentation

Presentation

Multistate time-multiplexed system for functional time-domain diffuse correlation spectroscopy with SNSPDs

Marco Renna, Zachary Starkweather, Mitchell Robinson, Nisan Ozana, Alyssa Martin, Stefan Carp, Maria Angela Franceschini

Proceedings Volume PC12376, PC123760D (2023) https://doi.org/10.1117/12.2650215

KEYWORDS: Spectroscopy, Brain, Signal to noise ratio, Blood circulation, Temporal resolution, Superconductors, Spatial resolution, Single photon detectors, Pulsed laser operation, Point spread functions

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Proceedings Article | 7 March 2023 Presentation

Presentation

Multi-wavelength multi-distance diffuse correlation spectroscopy system for assessment of premature infants’ cerebral hemodynamics

Nikola Otic, John Sunwoo, Yujing Huang, Alyssa Martin, Mitchell Robinson, Bernhard Zimmermann, Stefan Carp, Maria Franceschini, Marco Renna

Proceedings Volume PC12376, PC123760E (2023) https://doi.org/10.1117/12.2649662

KEYWORDS: Spectroscopy, Hemodynamics, Near infrared spectroscopy, Spectroscopes, Single photon detectors, Scattering, Photodetectors, Optical properties, Multiplexing, Mode conditioning cables

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SPIE Journal Paper | 24 January 2023 Open Access

Open Access

Diffuse correlation spectroscopy: current status and future outlook

Stefan A. Carp, Mitchell B. Robinson, Maria A. Franceschini

NPh, Vol. 10, Issue 01, 013509, (January 2023) https://doi.org/10.1117/12.10.1117/1.NPh.10.1.013509

KEYWORDS: Signal to noise ratio, Spectroscopy, Brain, Tissues, Near infrared spectroscopy, Source detector separation, Autocorrelation, Signal detection, Monte Carlo methods, Magnetic resonance imaging

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SPIE Journal Paper | 30 August 2022 Open Access

Open Access

Optical imaging and spectroscopy for the study of the human brain: status report

Hasan Ayaz, Wesley Baker, Giles Blaney, David Boas, Heather Bortfeld, Kenneth Brady, Joshua Brake, Sabrina Brigadoi, Erin M. Buckley, Stefan Carp, Robert Cooper, Kyle Cowdrick, Joseph Culver, Ippeita Dan, Hamid Dehghani, Anna Devor, Turgut Durduran, Adam Eggebrecht, Lauren Emberson, Qianqian Fang, Sergio Fantini, Maria Angela Franceschini, Jonas Fischer, Judit Gervain, Joy Hirsch, Keum-Shik Hong, Roarke Horstmeyer, Jana Kainerstorfer, Tiffany Ko, Daniel Licht, Adam Liebert, Robert Luke, Jennifer Lynch, Jaume Mesquida, Rickson Mesquita, Noman Naseer, Sergio Novi, Felipe Orihuela-Espina, Thomas O'Sullivan, Darcy Peterka, Antonio Pifferi, Luca Pollonini, Angelo Sassaroli, João Ricardo Sato, Felix Scholkmann, Lorenzo Spinelli, Vivek Srinivasan, Keith St. Lawrence, Ilias Tachtsidis, Yunjie Tong, Alessandro Torricelli, Tara Urner, Heidrun Wabnitz, Martin Wolf, Ursula Wolf, Shiqi Xu, Changhuei Yang, Arjun Yodh, Meryem Yücel, Wenjun Zhou

NPh, Vol. 9, Issue S2, S24001, (August 2022) https://doi.org/10.1117/12.10.1117/1.NPh.9.S2.S24001

KEYWORDS: Brain, Near infrared spectroscopy, Neuroimaging, Imaging spectroscopy, Sensors, Optical imaging, Optical spectroscopy imaging, Optical spectroscopy, Spectroscopy, Tissue optics

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Proceedings Article | 30 May 2022 Presentation

Presentation

Monitoring cerebral blood flow with superconducting nanowire detectors

Maria Franceschini, Nisan Ozana, Mitchell Robinson, Megan Blackwell, Stefan Carp, Marco Renna

Proceedings Volume PC12089, PC1208907 (2022) https://doi.org/10.1117/12.2622923

KEYWORDS: Superconductors, Sensors, Nanowires, Cerebral blood flow, Signal to noise ratio, Near infrared spectroscopy, Photon counting, Traumatic brain injury, Spectroscopy, Speckle

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Proceedings Article | 30 May 2022 Presentation

Presentation

A novel 32x32 InP/ InGaAs SPAD array for multi-channel time-gated diffuse correlation spectroscopy

Marco Renna, Jonathan Richardson, George Jordy, Tom Cheng, Eric Ringdahl, Mitchell Robinson, Nisan Ozana, Niyom Lue, Brian Aull, Stefan Carp, Erik Duerr, Maria Angela Franceschini, Megan Blackwell

Proceedings Volume PC12089, PC120890E (2022) https://doi.org/10.1117/12.2619112

KEYWORDS: Indium gallium arsenide, Spectroscopes, Sensors, Photons, Tissue optics, Spectroscopy, Imaging systems, Head, Brain, Single photon detectors

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Proceedings Article | 2 March 2022 Presentation

Presentation

Design and characterization of a multi-channel time-gated diffuse correlation spectroscopy system at 1064nm

Marco Renna, Jonathan Richardson, George Jordy, Tom Cheng, Mitchell Robinson, Nisan Ozana, Dibbyan Mazumder, Niyom Lue, Brian Aull, Bernhard Zimmerman, Stefan Carp, Erik Duerr, David Boas, Maria Angela Franceschini, Megan Blackwell

Proceedings Volume PC11959, PC1195908 (2022) https://doi.org/10.1117/12.2610207

KEYWORDS: Spectroscopes, Spectroscopy, Sensors, Photons, Imaging systems, Head, Single photon detectors, Single photon, Sensor performance, Semiconductor lasers

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SPIE Journal Paper | 17 February 2022 Open Access

Open Access

Erratum: Improved accuracy of cerebral blood flow quantification in the presence of systemic physiology cross-talk using multi-layer Monte Carlo modeling

Melissa Wu, Suk-Tak Chan, Dibbyan Mazumder, Davide Tamborini, Kimberly Stephens, Bin Deng, Parya Farzam, Joyce Chu, Maria Angela Franceschini, Jason Qu, Stefan Carp

NPh, Vol. 9, Issue 01, 019801, (February 2022) https://doi.org/10.1117/12.10.1117/1.NPh.9.1.019801

KEYWORDS: Physiology, Monte Carlo methods, Cerebral blood flow, Neurophotonics, Biomedical optics, Radiology, Radio optics, Medicine

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SPIE Journal Paper | 19 August 2021 Open Access

Open Access

Superconducting nanowire single-photon sensing of cerebral blood flow

Nisan Ozana, Alexander Zavriyev, Dibbyan Mazumder, Mitchell Robinson, Kutlu Kaya, Megan Blackwell, Stefan Carp, Maria Angela Franceschini

NPh, Vol. 8, Issue 03, 035006, (August 2021) https://doi.org/10.1117/12.10.1117/1.NPh.8.3.035006

KEYWORDS: Signal to noise ratio, Photons, Sensors, Brain, Superconductors, Nanowires, Cerebral blood flow, Blood circulation, Neurophotonics, Modulation

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SPIE Journal Paper | 12 August 2021 Open Access

Open Access

Optimization of time domain diffuse correlation spectroscopy parameters for measuring brain blood flow

Dibbyan Mazumder, Melissa Wu, Nisan Ozana, Davide Tamborini, Maria Angela Franceschini, Stefan Carp

NPh, Vol. 8, Issue 03, 035005, (August 2021) https://doi.org/10.1117/12.10.1117/1.NPh.8.3.035005

KEYWORDS: Photons, Monte Carlo methods, Picosecond phenomena, Sensors, Head, Tissue optics, Spectroscopy, Brain, Blood circulation, Neurophotonics

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Significance: Time domain diffuse correlation spectroscopy (TD-DCS) can offer increased sensitivity to cerebral hemodynamics and reduced contamination from extracerebral layers by differentiating photons based on their travel time in tissue. We have developed rigorous simulation and evaluation procedures to determine the optimal time gate parameters for monitoring cerebral perfusion considering instrumentation characteristics and realistic measurement noise. Aim: We simulate TD-DCS cerebral perfusion monitoring performance for different instrument response functions (IRFs) in the presence of realistic experimental noise and evaluate metrics of sensitivity to brain blood flow, signal-to-noise ratio (SNR), and ability to reject the influence of extracerebral blood flow across a variety of time gates to determine optimal operating parameters. Approach: Light propagation was modeled on an MRI-derived human head geometry using Monte Carlo simulations for 765- and 1064-nm excitation wavelengths. We use a virtual probe with a source–detector separation of 1 cm placed in the pre-frontal region. Performance metrics described above were evaluated to determine optimal time gate(s) for different IRFs. Validation of simulation noise estimates was done with experiments conducted on an intralipid-based liquid phantom. Results: We find that TD-DCS performance strongly depends on the system IRF. Among Gaussian pulse shapes, ∼300 ps pulse length appears to offer the best performance, at wide gates (500 ps and larger) with start times 400 and 600 ps after the peak of the TPSF at 765 and 1064 nm, respectively, for a 1-s integration time at photon detection rates seen experimentally (600 kcps at 765 nm and 4 Mcps at 1064 nm). Conclusions: Our work shows that optimal time gates satisfy competing requirements for sufficient sensitivity and sufficient SNR. The achievable performance is further impacted by system IRF with ∼300 ps quasi-Gaussian pulse obtained using electro-optic laser shaping providing the best results.

Proceedings Article | 5 March 2021 Presentation

Presentation

Continuous wave diffuse correlation spectroscopy beyond the water peak enabled by InGaAs SPAD cross correlation

Mitchell Robinson, Stefan Carp, Adriano Peruch, Nisan Ozana, Maria Franceschini

Proceedings Volume 11629, 116291Q (2021) https://doi.org/10.1117/12.2578914

KEYWORDS: Spectroscopy, Indium gallium arsenide, Sensors, Blood circulation, Silicon, Signal to noise ratio, Photons, Standards development, Single photon

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Proceedings Article | 5 March 2021 Presentation

Presentation

Demonstrating the potential role of a cerebral blood flow monitor during cardiac surgery with hypothermic circulatory arrest

Alexander Zavriyev, Kutlu Kaya, Parisa Farzam, Parya Farzam, John Sunwoo, Arminder Jassar, Thoralf Sundt, Stefan Carp, Maria Angela Franceschini, Jason Qu

Proceedings Volume 11629, 116290C (2021) https://doi.org/10.1117/12.2578758

KEYWORDS: Surgery, Cerebral blood flow, Near infrared spectroscopy, Brain, Blood circulation, Blood, Spectroscopy, Oxygen, Neuroprotection

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Proceedings Article | 5 March 2021 Presentation

Presentation

High framerate, InGaAs camera for interferometric diffuse correlation spectroscopy (iDCS) beyond the water peak

Mitchell Robinson, Stefan Carp, Adriano Peruch, Nisan Ozana, Maria Franceschini

Proceedings Volume 11641, 116410O (2021) https://doi.org/10.1117/12.2578894

KEYWORDS: Spectroscopy, Indium gallium arsenide, Cameras, Sensors, Interferometry, Signal to noise ratio, Scattering, Blood circulation, Tissue optics

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Proceedings Article | 5 March 2021 Presentation

Presentation

Multimodal optical assessment of breast tumor aggressiveness and progression in murine models

Bin Deng, Ailis Muldoon, Rahul Pal, Alana Ross, Pamela Pantazopoulos, Zdravka Medarova, Anand T. Kumar, Stefan Carp

Proceedings Volume 11634, 116340B (2021) https://doi.org/10.1117/12.2577699

KEYWORDS: Tumors, Breast, Near infrared spectroscopy, Breast cancer, Tumor growth modeling, Spectroscopy, Luminescence, Indocyanine green, Imaging spectroscopy, Fluorescence spectroscopy

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Proceedings Article | 5 March 2021 Presentation

Presentation

Deep learning enabled high-speed image reconstruction for breast diffuse optical tomography

Bin Deng, Hanxue Gu, Stefan Carp

Proceedings Volume 11639, 116390B (2021) https://doi.org/10.1117/12.2577736

KEYWORDS: Image restoration, Diffuse optical tomography, Breast, Process modeling, Tumors, Reconstruction algorithms, Data modeling, Tissue optics, Spherical lenses, Optimization (mathematics)

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Proceedings Article | 5 March 2021 Presentation

Presentation

Time-gated diffuse correlation spectroscopy for functional imaging via 1064 nm pulse laser shaping and superconducting nanowire single photon sensing

Nisan Ozana, Adriano Peruch, Mitchell Robinson, Dibbyan Mazumder, Megan Blackwell, Niyom Lue, Stefan Carp, Maria Angela Franceschini

Proceedings Volume 11629, 116292F (2021) https://doi.org/10.1117/12.2578909

KEYWORDS: Superconductors, Spectroscopy, Pulsed laser operation, Nanowires, Single photon, Photons, Imaging spectroscopy, Functional imaging, Brain, Tissue optics

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Proceedings Article | 5 March 2021 Presentation

Presentation

Characterization of cerebral blood flow quantification with diffuse correlation spectroscopy in the presence of systemic physiology cross-talk during a hypercapnic challenge

Stefan Carp, Melissa Wu, Suk-Tak Chan, Dibbyan Mazumder, Davide Tamborini, Kimberly Stephens, Bin Deng, Parya Farzam, Yawei Chu, Jason Qu, Maria Franceschini

Proceedings Volume 11629, 116291E (2021) https://doi.org/10.1117/12.2579027

KEYWORDS: Cerebral blood flow, Spectroscopy, Physiology, Tissue optics, Carbon dioxide, Ultrasonography, Tissues, Skin, Optical testing, Monte Carlo methods

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Proceedings Article | 5 March 2021 Presentation

Presentation

Simulation and experimental verification of optimal time domain diffuse correlation spectroscopy (TD-DCS) parameters for measuring brain blood flow

Dibbyan Mazumder, Melissa Wu, Nisan Ozana, Davide Tamborini, Maria Angela Franceschini, Stefan Carp

Proceedings Volume 11641, 116410F (2021) https://doi.org/10.1117/12.2577787

KEYWORDS: Monte Carlo methods, Blood circulation, Spectroscopy, Brain, Tissue optics, Tissues, Geometrical optics, Photons, Optical simulations, Motion measurement

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SPIE Journal Paper | 1 January 2021 Open Access

Open Access

Improved accuracy of cerebral blood flow quantification in the presence of systemic physiology cross-talk using multi-layer Monte Carlo modeling

Melissa Wu, Suk-Tak Chan, Dibbyan Mazumder, Davide Tamborini, Kimberly Stephens, Bin Deng, Parya Farzam, Joyce Yawei Chu, Maria Angela Franceschini, Jason Qu, Stefan Carp

NPh, Vol. 8, Issue 01, 015001, (January 2021) https://doi.org/10.1117/12.10.1117/1.NPh.8.1.015001

KEYWORDS: Monte Carlo methods, Modulation, Brain, Physiology, Cerebral blood flow, Skull, Scattering, Carbon monoxide, Blood circulation, Data modeling

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SPIE Journal Paper | 30 September 2020 Open Access

Open Access

Interferometric diffuse correlation spectroscopy improves measurements at long source–detector separation and low photon count rate

Mitchell Robinson, David Boas, Sava Sakadžic, Maria Angela Franceschini, Stefan Carp

JBO, Vol. 25, Issue 09, 097004, (September 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.9.097004

KEYWORDS: Signal to noise ratio, Homodyne detection, Heterodyning, Sensors, Blood circulation, Spectroscopy, Interferometry, Tissues, Signal detection, Photon counting

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Significance: The use of diffuse correlation spectroscopy (DCS) has shown efficacy in research studies as a technique capable of noninvasively monitoring blood flow in tissue with applications in neuromonitoring, exercise science, and breast cancer management. The ability of DCS to resolve blood flow in these tissues is related to the optical sensitivity and signal-to-noise ratio (SNR) of the measurements, which in some cases, particularly adult cerebral blood flow measurements, is inadequate in a significant portion of the population. Improvements to DCS sensitivity and SNR could allow for greater clinical translation of this technique. Aim: Interferometric diffuse correlation spectroscopy (iDCS) was characterized and compared to traditional homodyne DCS to determine possible benefits of utilizing heterodyne detection. Approach: An iDCS system was constructed by modifying a homodyne DCS system with fused fiber couplers to create a Mach–Zehnder interferometer. Comparisons between homodyne and heterodyne detection were performed using an intralipid phantom characterized at two extended source–detector separations (2.4, 3.6 cm), different photon count rates, and a range of reference arm power levels. Characterization of the iDCS signal mixing was compared to theory. Precision of the estimation of the diffusion coefficient and SNR of the autocorrelation curve were compared between different measurement conditions that mimicked what would be seen in vivo. Results: The mixture of signals present in the heterodyne autocorrelation function was found to agree with the derived theory and resulted in accurate measurement of the diffusion coefficient of the phantom. Improvement of the SNR of the autocorrelation curve up to ∼2 × and up to 80% reduction in the variability of the diffusion coefficient fit were observed for all measurement cases as a function of increased reference arm power. Conclusions: iDCS has the potential to improve characterization of blood flow in tissue at extended source–detector separations, enhancing depth sensitivity and SNR.

SPIE Journal Paper | 29 September 2020 Open Access

Open Access

Diffuse correlation spectroscopy measurements of blood flow using 1064 nm light

Stefan Carp, Davide Tamborini, Dibbyan Mazumder, Kuan-Cheng Wu, Mitchell Robinson, Kimberly Stephens, Oleg Shatrovoy, Niyom Lue, Nisan Ozana, Megan Blackwell, Maria Angela Franceschini

JBO, Vol. 25, Issue 09, 097003, (September 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.9.097003

KEYWORDS: Blood circulation, Absorption, Scattering, Signal to noise ratio, Tissue optics, Near infrared spectroscopy, Spectroscopy, Tissues, Signal attenuation, Sensors

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Proceedings Article | 20 April 2020 Presentation

Presentation

Overlapping volumes, acousto-optic modulated diffuse correlation spectroscopy for increased depth sensitivity (Conference Presentation)

Mitchell Robinson, Stefan Carp, Sava Sakadzic, Adriano Peruch, Davide Tamborini, Maria Angela Franceschini

Proceedings Volume 11240, 112402T (2020) https://doi.org/10.1117/12.2546630

KEYWORDS: Modulation, Spectroscopy, Acousto-optics, Ultrasonography, Blood circulation, Tissue optics, Brain, Transducers, Speckle, Skull

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Proceedings Article | 12 March 2020 Paper

Paper

Towards automatic time gating for time-domain diffuse correlation spectroscopy

Jing Wang, Akhil Goel, Lorenzo Vigano, Mitchell Robinson, Stefan Carp, Maria Franceschini, Megan Blackwell

Proceedings Volume 11216, 112160Y (2020) https://doi.org/10.1117/12.2545298

KEYWORDS: Photons, Blood, Liver, Tissue optics, Signal to noise ratio, Tissues, Monte Carlo methods, Near infrared spectroscopy, Computer simulations, Picosecond phenomena

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Proceedings Article | 10 March 2020 Presentation

Presentation

Multi-element interferometric diffuse correlation spectroscopy at 1064 nm (Conference Presentation)

Mitchell Robinson, Davide Tamborini, Adriano Peruch, Stefan Carp, Maria Angela Franceschini

Proceedings Volume 11253, 112530I (2020) https://doi.org/10.1117/12.2546350

KEYWORDS: Interferometry, Multi-element lenses, Spectroscopy, Signal detection, Blood circulation, Single photon detectors, Sensors, Brain, Interferometers, Tissue optics

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Proceedings Article | 9 March 2020 Presentation

Presentation

Novel detector solutions for diffuse correlation spectroscopy at 1064 nm (Conference Presentation)

Megan Blackwell, Robert Berger, George Jordy, Jonathan Frechette, Brian Aull, Erik Duerr, Mitchell Robinson, Davide Tamborini, Stefan Carp, Maria Angela Franceschini

Proceedings Volume 11239, 112390E (2020) https://doi.org/10.1117/12.2545178

KEYWORDS: Sensors, Spectroscopy, Photodetectors, Signal to noise ratio, Single photon detectors, Readout integrated circuits, Integrated circuit design, Quenching (fluorescence), Computer simulations, Performance modeling

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Proceedings Article | 9 March 2020 Presentation

Presentation

Simulation of time domain diffuse correlation spectroscopy (TD-DCS) performance for measuring brain blood flow in the presence of noise with realistic sources and detectors (Conference Presentation)

Dibbyan Mazumder, Davide Tamborini, Melissa Wu, Maria Franceschini, Stefan Carp

Proceedings Volume 11239, 112390G (2020) https://doi.org/10.1117/12.2544365

KEYWORDS: Blood circulation, Brain, Spectroscopy, Sensors, Tissue optics, Tissues, Motion measurement, Blood, Cerebral blood flow, Contamination

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Proceedings Article | 9 March 2020 Presentation

Presentation

Model impact in resolving DCS CBF measurements from systemic variations in blood flow (Conference Presentation)

Melissa Wu, Davide Tamborini, Kimberly Stephens, Dibbyan Mazumder, Parya Farzam, Suk-Tak Chan, Jason Qu, Maria Franceschini, Stefan Carp

Proceedings Volume 11226, 112260X (2020) https://doi.org/10.1117/12.2546699

KEYWORDS: Blood circulation, Natural surfaces, Tissue optics, Magnetic resonance imaging, Monte Carlo methods, Data modeling, Performance modeling, Spectroscopy, Brain, Cerebral blood flow

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Proceedings Article | 4 March 2019 Presentation

Presentation

Quantitative depth selective measurements of flow using acousto-optic diffuse correlation spectroscopy (Conference Presentation)

Mitchell Robinson, Stefan Carp, David Boas, Maria Angela Franceschini

Proceedings Volume 10878, 108782V (2019) https://doi.org/10.1117/12.2510349

KEYWORDS: Blood circulation, Acousto-optics, Spectroscopy, Speckle, Ultrasonography, Particles, Tissues, Sensors, New and emerging technologies, Biological research

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Proceedings Article | 4 March 2019 Presentation

Presentation

Connecting theory to the signal dynamics of interferometric diffuse correlation spectroscopy (Conference Presentation)

Mitchell Robinson, Stefan Carp, Davide Tamborini, David Boas, Maria Angela Franceschini

Proceedings Volume 10864, 108640E (2019) https://doi.org/10.1117/12.2510153

KEYWORDS: Spectroscopy, Interferometry, Sensors, Signal detection, Detection theory, Photon counting, Particles, Tissues, Signal attenuation, Single mode fibers

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SPIE Journal Paper | 19 October 2018 Open Access

Open Access

Tissue oxygen saturation predicts response to breast cancer neoadjuvant chemotherapy within 10 days of treatment

Jeffrey M. Cochran, David R. Busch, Anaïs Leproux, Zheng Zhang, Thomas D. O’Sullivan, Albert E. Cerussi, Philip M. Carpenter, Rita S. Mehta, Darren Roblyer, Wei Yang, Keith D. Paulsen, Brian Pogue, Shudong Jiang, Peter A. Kaufman, So Hyun Chung, Mitchell Schnall, Bradley S. Snyder, Nola Hylton, Stefan A. Carp, Steven J. Isakoff, David Mankoff, Bruce J. Tromberg, Arjun G. Yodh

JBO, Vol. 24, Issue 02, 021202, (October 2018) https://doi.org/10.1117/12.10.1117/1.JBO.24.2.021202

KEYWORDS: Tumors, Tissues, Oxygen, Breast, Tissue optics, Data modeling, Breast cancer, Tumor growth modeling, Radiology, Magnetic resonance imaging

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Proceedings Article | 14 March 2018 Presentation

Presentation

Fluorescence lifetime-based contrast enhancement of Indocyanine green-labelled tumors (Conference Presentation)

Anand Kumar, Stefan Carp

Proceedings Volume 10478, 104780A (2018) https://doi.org/10.1117/12.2290904

KEYWORDS: Tumors, Luminescence, Fluorescence spectroscopy, Surgery, Tissues, Indocyanine green, In vivo imaging, Breast, Brain, Target detection

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Proceedings Article | 12 February 2018 Paper

Paper

Measurement of shear-induced diffusion of red blood cells using dynamic light scattering-optical coherence tomography

Jianbo Tang, Sefik Evren Erdener, Baoqiang Li, Buyin Fu, Sava Sakadzic, Stefan Carp, Jonghwan Lee, David Boas

Proceedings Volume 10481, 104811N (2018) https://doi.org/10.1117/12.2290345

KEYWORDS: Diffusion, Blood circulation, Optical coherence tomography, Blood, Blood vessels, Particles, Dynamic light scattering, Velocity measurements, Light scattering, Tomography

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SPIE Journal Paper | 17 August 2017 Open Access

Open Access

Performance assessment of diffuse optical spectroscopic imaging instruments in a 2-year multicenter breast cancer trial

Anaïs Leproux, Thomas O’Sullivan, Albert Cerussi, Amanda Durkin, Brian Hill, Nola Hylton, Arjun Yodh, Stefan Carp, David Boas, Shudong Jiang, Keith Paulsen, Brian Pogue, Darren Roblyer, Wei Yang, Bruce Tromberg

JBO, Vol. 22, Issue 12, 121604, (August 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.12.121604

KEYWORDS: Absorption, Scattering, Calibration, Diffuse optical imaging, Optical imaging, Tissue optics, Reflectivity, Optical properties, Spectroscopes, Imaging spectroscopy

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SPIE Journal Paper | 27 April 2017 Open Access

Open Access

Multimodal breast cancer imaging using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis

Bernhard Zimmermann, Bin Deng, Bhawana Singh, Mark Martino, Juliette Selb, Qianqian Fang, Amir Sajjadi, Jayne Cormier, Richard Moore, Daniel Kopans, David Boas, Mansi Saksena, Stefan Carp

JBO, Vol. 22, Issue 04, 046008, (April 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.4.046008

KEYWORDS: Digital breast tomosynthesis, Breast, Sensors, Optical fibers, Absorption, X-rays, Breast cancer, Mammography, Tumors, Imaging systems

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Proceedings Article | 19 April 2017 Presentation

Presentation

Improved accuracy of brain oxygen metabolism measurements using multi-distance diffuse correlation spectroscopy and near infrared spectroscopy together with a Monte Carlo light transport model (Conference Presentation)

Stefan Carp, David Boas, Juliette Selb

Proceedings Volume 10051, 1005113 (2017) https://doi.org/10.1117/12.2252577

KEYWORDS: Near infrared spectroscopy, Monte Carlo methods, Brain, Oxygen, Spectroscopy, Mode conditioning cables, Tissues, Head, Magnetic resonance imaging, Thermal modeling

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Proceedings Article | 19 April 2017 Presentation

Presentation

Measuring temperature induced phase change kinetics in subcutaneous fatty tissues using near infrared spectroscopy, magnetic resonance imaging and optical coherence tomography (Conference Presentation)

Amir Sajjadi, Stefan Carp, Dieter Manstein

Proceedings Volume 10037, 100370M (2017) https://doi.org/10.1117/12.2250898

KEYWORDS: Crystals, Near infrared spectroscopy, Tissues, Optical coherence tomography, Scattering, Tissue optics, Temperature metrology, Spectroscopy, Skin, Magnetic resonance imaging

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SPIE Journal Paper | 11 April 2017 Open Access

Open Access

Fluorescence lifetime-based contrast enhancement of indocyanine green-labeled tumors

Anand Kumar, Stefan Carp, Jing Yang, Alana Ross, Zdravka Medarova, Chongzhao Ran

JBO, Vol. 22, Issue 04, 040501, (April 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.4.040501

KEYWORDS: Tumors, Luminescence, Tissues, Atrial fibrillation, Breast, Solids, Fluorescence spectroscopy, Tissue optics, Error analysis

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SPIE Journal Paper | 13 June 2016 Open Access

Open Access

Establishing the diffuse correlation spectroscopy signal relationship with blood flow

David Boas, Sava Sakadžić, Juliette Selb, Parisa Farzam, Maria Franceschini, Stefan Carp

NPh, Vol. 3, Issue 03, 031412, (June 2016) https://doi.org/10.1117/12.10.1117/1.NPh.3.3.031412

KEYWORDS: Blood circulation, Scattering, Monte Carlo methods, Blood, Diffusion, Spectroscopy, Tissues, Tissue optics, Light scattering, Motion measurement

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SPIE Journal Paper | 26 January 2016 Open Access

Open Access

Frequency domain near-infrared multiwavelength imager design using high-speed, direct analog-to-digital conversion

Bernhard Zimmermann, Qianqian Fang, David Boas, Stefan Carp

JBO, Vol. 21, Issue 01, 016010, (January 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.1.016010

KEYWORDS: Sensors, Imaging systems, Optical properties, Absorption, Scattering, Tissue optics, Breast, Modulation, Field programmable gate arrays, Signal detection

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SPIE Journal Paper | 6 August 2014 Open Access

Open Access

Sensitivity of near-infrared spectroscopy and diffuse correlation spectroscopy to brain hemodynamics: simulations and experimental findings during hypercapnia

Juliette Selb, David Boas, Suk-Tak Chan, Karleyton Evans, Erin Buckley, Stefan Carp

NPh, Vol. 1, Issue 01, 015005, (August 2014) https://doi.org/10.1117/12.10.1117/1.NPh.1.1.015005

KEYWORDS: Near infrared spectroscopy, Brain, Monte Carlo methods, Mercury, Blood circulation, Hemodynamics, Blood, Spectroscopy, Head, Absorption

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Proceedings Article | 25 March 2013 Paper

Paper

Dynamic optical breast imaging for neoadjuvant therapy monitoring

Amir Sajjadi, Christy Wanyo, Qianqian Fang, David Boas, Steven Isakoff, Stefan Carp

Proceedings Volume 8578, 85780I (2013) https://doi.org/10.1117/12.2004884

KEYWORDS: Breast, Tumors, Hemodynamics, Optical imaging, Tissues, Imaging systems, Breast cancer, Tissue optics, Optical testing

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SPIE Journal Paper | 1 November 2007 Open Access

Open Access

Optoacoustic imaging based on the interferometric measurement of surface displacement

Stefan Carp, Vasan Venugopalan

JBO, Vol. 12, Issue 06, 064001, (November 2007) https://doi.org/10.1117/12.10.1117/1.2812665

KEYWORDS: Acoustics, Interferometry, Natural surfaces, Image resolution, Image restoration, Tissues, Interferometers, Laser beam diagnostics, Content addressable memory, Reconstruction algorithms

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Proceedings Article | 1 March 2007 Paper

Paper

Reconstruction of tissue dynamics in the compressed breast using multiplexed measurements and temporal basis functions

Gregory Boverman, Eric Miller, Dana Brooks, Qianqian Fang, S. Carp, J. Selb, David Boas

Proceedings Volume 6434, 643413 (2007) https://doi.org/10.1117/12.708306

KEYWORDS: Breast, Absorption, Tissues, Tissue optics, Oxygen, Image restoration, Hemodynamics, Imaging systems, Blood, Multiplexing

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Proceedings Article | 20 February 2007 Paper

Paper

Clinical data analysis for the combined optical and tomosynthesis breast imaging

Qianqian Fang, Juliette Selb, Stefan Carp, Greg Boverman, Daniel Kopans, Richard Moore, David Boas

Proceedings Volume 6431, 64310H (2007) https://doi.org/10.1117/12.701623

KEYWORDS: Breast, X-rays, Tissues, Imaging systems, X-ray imaging, Breast imaging, Tissue optics, Mammography, Sensors

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SPIE Journal Paper | 1 November 2006 Open Access

Open Access

Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements

Stefan Carp, Tina Kauffman, Qianqian Fang, Elizabeth Rafferty, Richard Moore, Daniel Kopans, David Boas

JBO, Vol. 11, Issue 06, 064016, (November 2006) https://doi.org/10.1117/12.10.1117/1.2397572

KEYWORDS: Breast, Tissues, Oxygen, Blood, Tissue optics, Blood circulation, Optical fibers, Scattering, Positron emission tomography, Spectroscopy

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Proceedings Article | 25 April 2005 Paper

Paper

3D interferometric optoacoustic imaging

Stefan Carp, Vasan Venugopalan

Proceedings Volume 5697, (2005) https://doi.org/10.1117/12.591134

KEYWORDS: Tissues, Interferometry, Imaging spectroscopy, Content addressable memory, 3D image processing, Image restoration, Natural surfaces, Photography, Blood vessels, Mirrors

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Proceedings Article | 12 July 2004 Paper

Paper

POISe: pulsed optoacoustic interferometric spectroscopy and imaging

Stefan Carp, Arnold Guerra, Samuel Duque, Vasan Venugopalan

Proceedings Volume 5320, (2004) https://doi.org/10.1117/12.529675

KEYWORDS: Imaging spectroscopy, Tissues, Natural surfaces, Bragg cells, Interferometry, Image restoration, Interferometers, Absorption, Spectroscopy, Tissue optics

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SPIE Journal Paper | 1 May 2004 Open Access

Open Access

Radiative transport in the delta-P1 approximation: accuracy of fluence rate and optical penetration depth predictions in turbid semi-infinite media

Stefan Carp, Scott Prahl, Vasan Venugopalan

JBO, Vol. 9, Issue 03, (May 2004) https://doi.org/10.1117/12.10.1117/1.1695412

KEYWORDS: Gaussian beams, Monte Carlo methods, Scattering, Collimation, Refractive index, Optical properties, Light scattering, Solids, Absorption, Biomedical optics

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Showing 5 of 65 publications

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