Dr. Subrata Batabyal Profile

Dr. Subrata Batabyal

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Publications (13)

Proceedings Article | 5 March 2021 Presentation

Development and functional characterization of retinal dystrophy model using targeted layer-specific laser microirradiation

Michael Carlson, Sanghoon Kim, Subrata Batabyal, Samarendra Mohanty

Proc. SPIE. 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics

KEYWORDS: Rods, Pathophysiology, Injuries, Visual process modeling, Retina, Optogenetics, Structural imaging, Systems modeling, Cones, Animal model studies

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Proceedings Article | 5 March 2021 Presentation

Neuroprotection by optical delivery of therapeutic gene into retina

Subrata Batabyal, Sanghoon Kim, Michael Carlson, Houssam Al-Saad, Jazlyn Gallego, Adnan Dibas, Samarendra Mohanty

Proc. SPIE. 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics

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Proceedings Article | 9 March 2020 Presentation

Multifractal OCT for optical detection of retinal function (Conference Presentation)

Subrata Batabyal, Sanghoon Kim, Michael Carlson, Weldon Wright, Samarendra Mohanty

Proc. SPIE. 11227, Optogenetics and Optical Manipulation 2020

KEYWORDS: Statistical analysis, Visual analytics, Visualization, Optical coherence tomography, Retina, Diagnostics, Interferometry, In vivo imaging

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Proceedings Article | 19 February 2020 Paper

Optical modulation and functional mapping of cortical activities using molecular actuator-sensor

Darryl Narcisse, Sourajit Mitra Mustafi, Michael Carlson, Subrata Batabyal, Weldon Wright, Samarendra Mohanty

Proc. SPIE. 11227, Optogenetics and Optical Manipulation 2020

KEYWORDS: Actuators, Modulation, Visualization, Sensors, Calcium, Optogenetics, Bioluminescence, Visual cortex, Brain mapping, Neurons

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Proceedings Article | 14 March 2018 Presentation

Targeted nano-enhanced Optical delivery of opsin for dry-AMD therapy (Conference Presentation)

Sivakumar Gajjeraman, Subrata Batabyal, Weldon Wright, Samarendra Mohanty

Proc. SPIE. 10482, Optogenetics and Optical Manipulation 2018

KEYWORDS: Gold, Visualization, Retina, Molecules, Laser optics, Mouse models, Nanorods

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Proceedings Article | 14 March 2018 Presentation

In-vivo label-free optical detection of neural activities in retina (Conference Presentation)

Subrata Batabyal, Sivakumar Gajjeraman, Weldon Wright, Samarendra Mohanty

Proc. SPIE. 10482, Optogenetics and Optical Manipulation 2018

KEYWORDS: Cornea, Visualization, Optical coherence tomography, Electrodes, Retina, In vivo imaging, Visual optics

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Proceedings Article | 14 March 2018 Presentation

Optical stimulation and monitoring of the visual system using bioluminescent opsin (Conference Presentation)

Samarendra Mohanty, Subrata Batabyal, Sivakumar Gajjeraman, Takeharu Nagai, Weldon Wright

Proc. SPIE. 10482, Optogenetics and Optical Manipulation 2018

KEYWORDS: Optical imaging, Modulation, Visualization, Visual system, Optogenetics, Bioluminescence, Retinal scanning, Visual cortex, Visual optics, Neurons

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SPIE Journal Paper | 27 September 2017

Publisher’s note: Restoring vision in mice with retinal degeneration using multicharacteristic opsin

Weldon Wright, Sivakumar Gajjeraman, Subrata Batabyal, Sanjay Pradhan, Sulagna Bhattacharya, Vasu Mahapatra, Ashutosh Tripathy, Samarendra Mohanty

NPh Vol. 4 Issue 04

KEYWORDS: Nanotechnology, Brain, Neurophotonics

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SPIE Journal Paper | 18 August 2017

Restoring vision in mice with retinal degeneration using multicharacteristic opsin

Weldon Wright, Sivakumar Gajjeraman, Subrata Batabyal, Sanjay Pradhan, Sulagna Bhattacharya, Vasu Mahapatra, Ashutosh Tripathy, Samarendra Mohanty

NPh Vol. 4 Issue 04

KEYWORDS: Retina, Visualization, Optogenetics, 3D modeling, Light emitting diodes, Therapeutics, Light, Neurophotonics, Luminescence, Eye

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SPIE Journal Paper | 29 June 2017

Ultrafast laser-assisted spatially targeted optoporation into cortical axons and retinal cells in the eye

Subrata Batabyal, Young-Tae Kim, Samarendra Mohanty

JBO Vol. 22 Issue 06

KEYWORDS: Molecules, Axons, Visualization, Ultrafast phenomena, Cones, Eye, Neurons, Molecular lasers, Tissues, Diffusion

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Proceedings Article | 19 April 2017 Presentation

Label-free optical detection of action potential in mammalian neurons (Conference Presentation)

Subrata Batabyal, Sarmishtha Satpathy, Loan Bui, Young-Tae Kim, Samarendra Mohanty, Digant Davé

Proc. SPIE. 10052, Optogenetics and Optical Manipulation

KEYWORDS: Gold, Signal to noise ratio, Luminescence, Phase interferometry, Neuroscience, Optogenetics, Action potentials, Electrophysiology, Singular optics, Neurons

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Electrophysiology techniques are the gold standard in neuroscience for studying functionality of a single neuron to a complex neuronal network. However, electrophysiology techniques are not flawless, they are invasive nature, procedures are cumbersome to implement with limited capability of being used as a high-throughput recording system. Also, long term studies of neuronal functionality with aid of electrophysiology is not feasible. Non-invasive stimulation and detection of neuronal electrical activity has been a long standing goal in neuroscience. Introduction of optogenetics has ushered in the era of non-invasive optical stimulation of neurons, which is revolutionizing neuroscience research. Optical detection of neuronal activity that is comparable to electro-physiology is still elusive. A number of optical techniques have been reported recording of neuronal electrical activity but none is capable of reliably measuring action potential spikes that is comparable to electro-physiology. Optical detection of action potential with voltage sensitive fluorescent reporters are potential alternatives to electrophysiology techniques. The heavily rely on secondary reporters, which are often toxic in nature with background fluorescence, with slow response and low SNR making them far from ideal. The detection of one shot (without averaging)-single action potential in a true label-free way has been elusive so far. In this report, we demonstrate the optical detection of single neuronal spike in a cultured mammalian neuronal network without using any exogenous labels. To the best of our knowledge, this is the first demonstration of label free optical detection of single action potentials in a mammalian neuronal network, which was achieved using a high-speed phase sensitive interferometer. We have carried out stimulation and inhibition of neuronal firing using Glutamate and Tetrodotoxin respectively to demonstrate the different outcome (stimulation and inhibition) revealed in optical signal. We hypothesize that the interrogating optical beam is modulated during neuronal firing by electro-motility driven membrane fluctuation in conjunction with electrical wave propagation in cellular system.

Proceedings Article | 26 April 2016 Presentation

Label free detection of optogenetically stimulated cellular activity by low coherence interferometry (Conference Presentation)

Sarmishtha Satpathy, Subrata Batabyal, Digant Dave, Samarendra Mohanty

Proc. SPIE. 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation

KEYWORDS: Microscopes, Refractive index, Coherence (optics), Luminescence, Interferometry, Optogenetics, Spatial resolution, Phase measurement, Electrophysiology, System integration

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Proceedings Article | 26 April 2016 Presentation

Activation of cells using femtosecond laser beam (Conference Presentation)

Subrata Batabyal, Sarmishtha Satpathy, Young-tae Kim, Samarendra Mohanty

Proc. SPIE. 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation

KEYWORDS: Thermography, Near infrared, Visible radiation, Femtosecond phenomena, Laser therapeutics, Tissues, Telecommunications, Optogenetics, Tissue optics, Pulsed laser operation

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Showing 5 of 13 publications

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