Prof. Thomas H. Foster Profile

Prof. Thomas H. Foster

at Univ of Rochester Medical Ctr

SPIE Involvement:

Author

Publications (31)

Proceedings Article | 5 March 2021 Presentation

Methylene blue photodynamic therapy to sterilize deep tissue abscess cavities: a phase 1 trial in progress and simulation study

Timothy Baran, Lam Nguyen, Thomas Foster, Ashwani Sharma

Proceedings Volume 11626, 116260N (2021) https://doi.org/10.1117/12.2575949

KEYWORDS: Monte Carlo methods, Photodynamic therapy, Tissue optics, Optical properties, Tissues, Safety, Resistance, Optical spectroscopy, In vivo imaging, Device simulation

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Proceedings Article | 1 March 2016 Paper

Intratumor photosensitizer injection for photodynamic therapy: Pre-clinical experience with methylene blue, Pc 4, and Photofrin

Timothy Baran, Thomas Foster

Proceedings Volume 9694, 969418 (2016) https://doi.org/10.1117/12.2229544

KEYWORDS: Photodynamic therapy, Tissue optics, Animal model studies, Tumors, Information technology, Skin, Eye, Biopsy

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Proceedings Article | 2 March 2015 Paper

Use of cylindrical diffusing fibers as detectors for interstitial tissue spectroscopy

Timothy Baran, Thomas Foster

Proceedings Volume 9308, 93080J (2015) https://doi.org/10.1117/12.2085543

KEYWORDS: Diffusers, Optical fibers, Sensors, Scattering, Optical properties, Tissue optics, Spectroscopy, Monte Carlo methods, Reflectors, Photodynamic therapy

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Proceedings Article | 14 April 2014 Paper

Recovery of optical properties from interstitial spectroscopy for photodynamic therapy treatment planning

Timothy Baran, Michael Fenn, Thomas Foster

Proceedings Volume 8931, 89310K (2014) https://doi.org/10.1117/12.2037808

KEYWORDS: Optical fibers, Spectroscopy, Optical properties, Photodynamic therapy, Sensors, Scattering, Monte Carlo methods, Absorption, Photodetectors, Solids

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SPIE Journal Paper | 22 October 2013 Open Access

Determination of optical properties by interstitial white light spectroscopy using a custom fiber optic probe

Timothy Baran, Michael Fenn, Thomas Foster

JBO, Vol. 18, Issue 10, 107007, (October 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.10.107007

KEYWORDS: Optical properties, Spectroscopy, Scattering, Absorption, Sensors, Tissue optics, Solids, Oxygen, Signal detection, Monte Carlo methods

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SPIE Journal Paper | 29 July 2013 Open Access

Enzyme-activatable imaging probe reveals enhanced neutrophil elastase activity in tumors following photodynamic therapy

Soumya Mitra, Kshitij Modi, Thomas Foster

JBO, Vol. 18, Issue 10, 101314, (July 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.10.101314

KEYWORDS: Tumors, Luminescence, Control systems, Photodynamic therapy, In vivo imaging, Imaging systems, MODIS, Confocal microscopy, Tissues, Magnesium

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SPIE Journal Paper | 17 September 2012 Open Access

Optical property measurements establish the feasibility of photodynamic therapy as a minimally invasive intervention for tumors of the kidney

Timothy Baran, Jeremy Wilson, Soumya Mitra, Jorge Yao, Edward Messing, David Waldman, Thomas Foster

JBO, Vol. 17, Issue 9, 098002, (September 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.9.098002

KEYWORDS: Tumors, Kidney, Optical properties, Optical fibers, Photodynamic therapy, Diffuse reflectance spectroscopy, Optical testing, Tissue optics, Absorption, Diffusers

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Proceedings Article | 16 February 2012 Paper

Effect of photodynamic therapy on single cancer cells studied by integrated Raman and angular scattering microscopy

Dustin Shipp, Soumya Mitra, Thomas Foster, Andrew Berger

Proceedings Volume 8219, 82190G (2012) https://doi.org/10.1117/12.909001

KEYWORDS: Raman spectroscopy, Raman scattering, Scattering, Photodynamic therapy, Light scattering, Microscopy, Laser scattering, Cancer, Proteins, Scatter measurement

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Proceedings Article | 8 September 2011 Paper

Illumination devices for uniform delivery of light to the oral cavity for photodynamic therapy

Cristina Canavesi, William Cassarly, Thomas Foster, Jannick Rolland

Proceedings Volume 8124, 812402 (2011) https://doi.org/10.1117/12.892400

KEYWORDS: Reflectors, Photodynamic therapy, Prototyping, Optics manufacturing, Cancer, Oncology, Reflectivity, Tissues, Ray tracing, Error analysis

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SPIE Journal Paper | 1 August 2011 Open Access

New Monte Carlo model of cylindrical diffusing fibers illustrates axially heterogeneous fluorescence detection: simulation and experimental validation

Timothy Baran, Thomas Foster

JBO, Vol. 16, Issue 08, 085003, (August 2011) https://doi.org/10.1117/12.10.1117/1.3613920

KEYWORDS: Diffusers, Luminescence, Optical fibers, Monte Carlo methods, Fluorescence spectroscopy, Photons, Scattering, Absorption, Tissue optics, Optical properties

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Proceedings Article | 9 March 2011 Paper

Quantitative analysis of tumor matrix patterns through statistical and topological texture features

Mahesh Nagarajan, Xiaoxing Han, Markus Huber, Thomas Foster, Edward Brown, Axel Wismüller

Proceedings Volume 7965, 79651E (2011) https://doi.org/10.1117/12.878619

KEYWORDS: Tumors, Second-harmonic generation, Collagen, Feature extraction, Machine learning, Image classification, Fuzzy logic, Statistical analysis, Quantitative analysis, Harmonic generation

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Proceedings Article | 9 September 2010 Paper

Design of illumination devices for delivery of photodynamic therapy in the oral cavity

Cristina Canavesi, Florian Fournier, Thomas Foster, Jannick Rolland

Proceedings Volume 7652, 76520Y (2010) https://doi.org/10.1117/12.868868

KEYWORDS: Reflectors, Photodynamic therapy, Reflectivity, 3D vision, Error analysis, 3D acquisition, Ray tracing, Coating, Fiber couplers, Fiber optic illuminators

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SPIE Journal Paper | 1 January 2010 Open Access

Imaging morphogenesis of Candida albicans during infection in a live animal

Soumya Mitra, Kristy Dolan, Thomas Foster, Melanie Wellington

JBO, Vol. 15, Issue 01, 010504, (January 2010) https://doi.org/10.1117/12.10.1117/1.3290243

KEYWORDS: Ear, In vivo imaging, Systems modeling, Yeast, Confocal microscopy, Luminescence, Organisms, Animal model studies, Pathogens, Veins

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Proceedings Article | 25 February 2009 Paper

In vivo optical imaging to visualize photodynamic therapy-induced immune responses

Soumya Mitra, Thomas Foster

Proceedings Volume 7178, 71780F (2009) https://doi.org/10.1117/12.808117

KEYWORDS: Tumors, In vivo imaging, Photodynamic therapy, Confocal microscopy, Ear, Luminescence, Tissues, Green fluorescent protein, Visualization, Optical imaging

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Proceedings Article | 18 February 2009 Paper

Monitoring blood flow and photobleaching during topical ALA PDT treatment

Theresa Sands, Ulas Sunar, Thomas Foster, Allan Oseroff

Proceedings Volume 7164, 71640U (2009) https://doi.org/10.1117/12.809217

KEYWORDS: Photodynamic therapy, Blood circulation, Tumors, Oxygen, Sensors, Skin, Luminescence, Cell death, Light, Optical fibers

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SPIE Journal Paper | 1 July 2008 Open Access

Antibody-labeled fluorescence imaging of dendritic cell populations in vivo

Ryan Cummings, Soumya Mitra, Edith Lord, Thomas Foster

JBO, Vol. 13, Issue 04, 044041, (July 2008) https://doi.org/10.1117/12.10.1117/1.2966122

KEYWORDS: In vivo imaging, Luminescence, Confocal microscopy, Tumors, Ear, Tissue optics, Liquid crystals, Tissues, Skin, Spatial resolution

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SPIE Journal Paper | 1 May 2008 Open Access

Monitoring Pc 4 photodynamic therapy in clinical trials of cutaneous T-cell lymphoma using noninvasive spectroscopy

Tammy Lee, Elma Baron, Thomas Foster

JBO, Vol. 13, Issue 03, 030507, (May 2008) https://doi.org/10.1117/12.10.1117/1.2939068

KEYWORDS: Luminescence, Photodynamic therapy, Reflectivity, Spectroscopy, Clinical trials, Absorption, Lymphoma, Fluorescence spectroscopy, Tissue optics, Control systems

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SPIE Journal Paper | 1 May 2007 Open Access

Characterization of lysosomal contribution to whole-cell light scattering by organelle ablation

Jeremy Wilson, Thomas Foster

JBO, Vol. 12, Issue 03, 030503, (May 2007) https://doi.org/10.1117/12.10.1117/1.2743971

KEYWORDS: Light scattering, Scattering, Particles, Luminescence, Mie scattering, Optical testing, Scatter measurement, Photodynamic therapy, Data modeling, Optical filters

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Proceedings Article | 6 March 2007 Paper

Optical molecular imaging in PDT

Soumya Mitra, John Snyder, Thomas Foster

Proceedings Volume 6427, 642706 (2007) https://doi.org/10.1117/12.698688

KEYWORDS: Tumors, In vivo imaging, Green fluorescent protein, Photodynamic therapy, Luminescence, Confocal microscopy, Proteins, Ear, Tissue optics, Tissues

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Proceedings Article | 16 February 2007 Paper

Fluence- and time-dependant lysosomal and mitochondrial damage induced by LS11 PDT characterized with light scattering

Jeremy Wilson, Thomas Foster

Proceedings Volume 6446, 64460F (2007) https://doi.org/10.1117/12.697458

KEYWORDS: Light scattering, Scattering, Scatter measurement, Mie scattering, Luminescence, Photodynamic therapy, Optical testing, Particles, Cell death, Microscopy

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SPIE Journal Paper | 1 January 2007 Open Access

Index-of-refraction-dependent subcellular light scattering observed with organelle-specific dyes

Jeremy Wilson, William Cottrell, Thomas Foster

JBO, Vol. 12, Issue 01, 014010, (January 2007) https://doi.org/10.1117/12.10.1117/1.2437765

KEYWORDS: Light scattering, Scattering, Refractive index, Mie scattering, Particles, Data modeling, Absorption, Scatter measurement, Optical spheres, Spectroscopy

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Proceedings Article | 6 March 2006 Paper

PDT-induced changes in light scattering from cells using lysosomal- vs. mitochondrial-localizing photosensitizers

Jeremy Wilson, Thomas Foster

Proceedings Volume 6139, 613903 (2006) https://doi.org/10.1117/12.644907

KEYWORDS: Light scattering, Scattering, Mie scattering, Photodynamic therapy, Particles, Data modeling, Luminescence, Scatter measurement, Optical spheres, Transmission electron microscopy

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Proceedings Article | 6 March 2006 Paper

System for providing simultaneous PDT delivery and dual spectroscopic monitoring in clinical basal cell carcinoma therapy

W. Cottrell, A. Oseroff, T. Foster

Proceedings Volume 6139, 613918 (2006) https://doi.org/10.1117/12.646535

KEYWORDS: Luminescence, Photodynamic therapy, Reflectivity, Platinum, Tissue optics, Switches, Oxygen, Spectroscopy, Optical properties, LabVIEW

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Proceedings Article | 8 April 2005 Paper

Light scattering reports early mitochondrial responses to photodynamic therapy

Jeremy Wilson, Thomas Foster

Proceedings Volume 5689, (2005) https://doi.org/10.1117/12.588729

KEYWORDS: Light scattering, Scattering, Photodynamic therapy, Mie scattering, Scatter measurement, Optical testing, Particles, Tissue optics, Absorption, Spectrophotometry

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Proceedings Article | 18 August 1997 Paper

Noninvasive near-infrared hemoglobin spectroscopy for in vivo monitoring of tumor oxygenation and response to oxygen modifiers

Edward Hull, Thomas Foster

Proceedings Volume 2979, (1997) https://doi.org/10.1117/12.280264

KEYWORDS: Absorption, Oxygen, Diffuse reflectance spectroscopy, Tumors, Scattering, Optical fibers, In vivo imaging, Blood, Spectroscopy, Tissue optics

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Proceedings Article | 18 August 1997 Paper

Two steady-state methods for localizing a fluorescent inhomogeneity in a turbid medium

Thomas Foster, Edward Hull, Michael Nichols, David Rifkin, Nina Schwartz

Proceedings Volume 2979, (1997) https://doi.org/10.1117/12.280220

KEYWORDS: Luminescence, Optical properties, Scattering, Signal detection, Absorption, Laser scattering, Diffuse reflectance spectroscopy, Tumors, Diffusion

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Proceedings Article | 7 May 1996 Paper

Microelectrode and optical measurements of oxygen in biological systems in vitro and in vivo

Thomas Foster, Michael Nichols, Irene Georgakoudi, Edward Hull

Proceedings Volume 2681, (1996) https://doi.org/10.1117/12.239567

KEYWORDS: Oxygen, Photodynamic therapy, Absorption, Tumors, Diffuse reflectance spectroscopy, Tissue optics, Electrodes, In vivo imaging, Optical fibers, Tissues

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Proceedings Article | 1 May 1995 Paper

Oxygen sensitivity of PDT determined from time-dependent electrode measurements in spheroids

Thomas Foster, Michael Nichols

Proceedings Volume 2392, (1995) https://doi.org/10.1117/12.208183

KEYWORDS: Oxygen, Photodynamic therapy, Diffusion, Electrodes, Data modeling, Tumors, Photochemistry, Absorption, Solids, Molecules

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Proceedings Article | 19 July 1994 Paper

Microelectrode measurements of photochemical oxygen depletion in multicell tumor spheroids during photodynamic therapy

Michael Nichols, Thomas Foster

Proceedings Volume 2133, (1994) https://doi.org/10.1117/12.179983

KEYWORDS: Oxygen, Photodynamic therapy, Diffusion, Electrodes, Tumors, Data modeling, Tumor growth modeling, In vivo imaging, Spherical lenses, Laser irradiation

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Proceedings Article | 18 June 1993 Paper

Mechanisms contributing to optimization of PDT with first-generation photosensitizers

Russell Hilf, Scott Gibson, Thomas Foster

Proceedings Volume 1881, (1993) https://doi.org/10.1117/12.146325

KEYWORDS: Tumors, Photodynamic therapy, Oxygen, Mesothelioma, In vivo imaging, Tumor growth modeling, Cancer, In vitro testing, Acquisition tracking and pointing, Sodium

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Proceedings Article | 1 June 1992 Paper

Analysis of photochemical oxygen consumption effects in photodynamic therapy (Invited Paper)

Thomas Foster, Scott Gibson, Yongli Gao, Russell Hilf

Proceedings Volume 1645, (1992) https://doi.org/10.1117/12.60933

KEYWORDS: Tumors, Oxygen, Photodynamic therapy, Capillaries, Tissues, Mesothelioma, Tumor growth modeling, Data modeling, Radiation effects, Diffusion

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