Prof. Tim K. Lee Profile

Prof. Tim K. Lee

Distinguished Scientist at BC Cancer Research Institute

SPIE Involvement:

Author

Publications (42)

Proceedings Article | 13 March 2024 Presentation

Data augmentation strategies for Raman spectral analysis: application for skin cancer discrimination

Jianhua Zhao, Harvey Lui, Sunil Kalia, Tim Lee, Haishan Zeng

Proceedings Volume PC12816, PC128160F (2024) https://doi.org/10.1117/12.3009005

KEYWORDS: Raman spectroscopy, Skin cancer, Machine learning, Lawrencium, Education and training, Cancer detection, Convolutional neural networks, Support vector machines, Statistical analysis, Skin

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Proceedings Article | 13 March 2024 Presentation

Multi-modal comparison of polarization and coherence-based skin measurement techniques: preliminary results

Daniel Louie, Sina Maloufi, Mitra Mirsalehi, Xin Zhou, Shuo Tang, Tim Lee

Proceedings Volume PC12816, PC1281603 (2024) https://doi.org/10.1117/12.3000555

KEYWORDS: Polarization, Skin, Physical coherence, Tissues, Speckle, Optical coherence tomography, Surface roughness, Optical coherence, Depolarization, Color

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Proceedings Article | 13 March 2024 Presentation + Paper

Analysis of attenuation coefficient and polarization-based contrasts in skin using polarization-sensitive optical coherence tomography

Mitra Mirsalehi, Sina Maloufi, Xin Zhou, Daniel Louie, Tim Lee, Shuo Tang

Proceedings Volume 12816, 128160D (2024) https://doi.org/10.1117/12.3001991

KEYWORDS: Optical coherence tomography, Skin, Attenuation, Absorption, Signal attenuation, Scattering, Tissues, Polarization, In vivo imaging, Image segmentation

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Proceedings Article | 17 March 2023 Presentation

Characterizing skin properties non-invasively by polarization-sensitive optical coherence tomography

Xin Zhou, Daniel Louie, Sina Maloufi, Yuheng Wang, Tim Lee, Shuo Tang

Proceedings Volume PC12352, PC123520S (2023) https://doi.org/10.1117/12.2649446

KEYWORDS: Skin, Optical coherence tomography, Tissues, Surface roughness, Polarization, Image segmentation, Collagen, Birefringence, Tissue optics, Statistical analysis

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Proceedings Article | 15 March 2023 Presentation

Development of a Stokes vector polarization speckle system for in vivo clinical applications (Conference Presentation)

Daniel Louie, Lioudmila Tchvialeva, Tim Lee

Proceedings Volume PC12382, PC123820D (2023) https://doi.org/10.1117/12.2647636

KEYWORDS: Polarization, Speckle, In vivo imaging, Polarimetry, Backscatter, Speckle pattern, Wave plates, Systems modeling, Stochastic processes, Motion measurement

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Proceedings Article | 8 March 2023 Presentation + Paper

Epidermal-dermal segmentation and polarization feature analysis using advanced Jones matrix optical coherence tomography

Sina Maloufi, Xin Zhou, Daniel Louie, Mitra Mirsalehi, Tim Lee, Shuo Tang

Proceedings Volume 12367, 123670O (2023) https://doi.org/10.1117/12.2653006

KEYWORDS: Skin, Optical coherence tomography, Birefringence, Polarization, Image segmentation, Depolarization, Matrices, Collagen, Tissues, Diseases and disorders

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Proceedings Article | 21 December 2021 Paper

Polarization-based skin cancer detection in vivo

Lioudmila Tchvialeva, Daniel Louie, Yuheng Wang, Sunil Kalia, Harvey Lui, Tim Lee

Proceedings Volume 12126, 121262P (2021) https://doi.org/10.1117/12.2621081

KEYWORDS: Polarization, Skin, Skin cancer, Cancer, Polarimetry, In vivo imaging, Diagnostics, Optical properties, Photodiodes, Melanoma

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SPIE Journal Paper | 8 March 2021 Open Access

Constructing a portable optical polarimetry probe for in-vivo skin cancer detection

Daniel Louie, Lioudmila Tchvialeva, Sunil Kalia, Harvey Lui, Tim Lee

JBO, Vol. 26, Issue 03, 035001, (March 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.3.035001

KEYWORDS: Polarization, Speckle, Polarimetry, Skin cancer, Tissue optics, Sensors, Skin, Semiconductor lasers, In vivo imaging, Photodiodes

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Proceedings Article | 19 February 2020 Paper

Polarization sensitive optical coherence tomography for assessing skin roughness

Xin Zhou, Daniel Louie, Sina Maloufi, Lin Huang, Qihao Liu, Lioudmila Tchvialeva, Tim Lee, Shuo Tang

Proceedings Volume 11211, 112110A (2020) https://doi.org/10.1117/12.2547139

KEYWORDS: Skin, Polarization, Optical coherence tomography, Melanoma, Natural surfaces, Skin cancer, Surface roughness, Tissues, Scattering, Absorption

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Proceedings Article | 26 February 2019 Presentation + Paper

One-shot Stokes polarimetry for low-cost skin cancer detection

Daniel Louie, Lioudmila Tchvialeva, Sunil Kalia, Harvey Lui, Tim Lee

Proceedings Volume 10869, 1086904 (2019) https://doi.org/10.1117/12.2509268

KEYWORDS: Polarization, Skin cancer, Speckle, Polarimetry, Semiconductor lasers, Optical filters, Sensors, Photodiodes, Skin, Cancer

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Proceedings Article | 24 January 2019 Paper

Generation and development of polarization speckle based on random walks of polarization phasor

Wei Wang, Tim Lee, Steen Hanson, Mitsuo Takeda

Proceedings Volume 11052, 110521N (2019) https://doi.org/10.1117/12.2523353

KEYWORDS: Polarization, Speckle, Polarizers, Stochastic processes, Wave plates, Modulation, Free space, Radio propagation, Speckle pattern, Optical components

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SPIE Journal Paper | 15 December 2018 Open Access

Degree of optical polarization as a tool for detecting melanoma: proof of principle

Daniel Louie, Jamie Phillips, Lioudmila Tchvialeva, Sunil Kalia, Harvey Lui, Wei Wang, Tim K. Lee

JBO, Vol. 23, Issue 12, 125004, (December 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.12.125004

KEYWORDS: Skin, Polarization, Melanoma, Polarimetry, In vivo imaging, Surface roughness, Skin cancer, Scattering, Photodiodes, Cancer

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Proceedings Article | 27 February 2018 Presentation + Paper

Computer-aided detection of basal cell carcinoma through blood content analysis in dermoscopy images

Pegah Kharazmi, Sunil Kalia, Harvey Lui, Z. Jane Wang, Tim Lee

Proceedings Volume 10575, 105750O (2018) https://doi.org/10.1117/12.2293353

KEYWORDS: Blood, Skin, Skin cancer, Independent component analysis, Tumors, Image segmentation, Computer-aided diagnosis, Image analysis, Feature extraction, Chromophores

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Proceedings Article | 14 February 2018 Paper

Stokes polarimetry probe for skin lesion evaluation: preliminary results

Daniel Louie, Lioudmilla Tchvialeva, Sunil Kalia, Harvey Lui, Tim Lee

Proceedings Volume 10467, 104670X (2018) https://doi.org/10.1117/12.2288761

KEYWORDS: Polarization, Skin, Polarimetry, Speckle, Sensors, Clinical trials, Surface roughness, In vivo imaging, Melanoma, Skin cancer

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Proceedings Article | 18 January 2018 Paper

Applications of polarization speckle in skin cancer detection and monitoring

Tim Lee, Lioudmila Tchvialeva, Jamie Phillips, Daniel Louie, Jianhua Zhao, Wei Wang, Harvey Lui, Sunil Kalia

Proceedings Volume 10612, 106121B (2018) https://doi.org/10.1117/12.2305383

KEYWORDS: Polarization, Speckle, Skin, Skin cancer, Cancer, Diffuse reflectance spectroscopy, Melanoma, Reflectivity, Speckle pattern, Scattering

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Proceedings Article | 19 April 2017 Presentation

Skin microrelief as a diagnostic tool (Conference Presentation)

Lioudmila Tchvialeva, Jamie Phillips, Haishan Zeng, David McLean, Harvey Lui, Tim Lee

Proceedings Volume 10037, 1003706 (2017) https://doi.org/10.1117/12.2249800

KEYWORDS: Cancer, Skin, Speckle, Melanoma, Diagnostics, Skin cancer, Calibration, Surface roughness, Silicon, Laser development

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Proceedings Article | 6 February 2017 Presentation + Paper

Findings toward the miniaturization of a laser speckle contrast device for skin roughness measurements

Daniel Louie, Lioudmilla Tchvialeva, Haishan Zeng, Tim Lee

Proceedings Volume 10037, 100370J (2017) https://doi.org/10.1117/12.2253227

KEYWORDS: Skin, Speckle, Semiconductor lasers, Polarization, In vivo imaging, CCD cameras, Thermal effects, Medical devices, Calibration, Cameras, Backscatter, Scattering, Skin cancer

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SPIE Journal Paper | 11 July 2016 Open Access

Backscattering of linearly polarized light from turbid tissue-like scattering medium with rough surface

Alexander Doronin, Lioudmila Tchvialeva, Igor Markhvida, Tim Lee, Igor Meglinski

JBO, Vol. 21, Issue 07, 071117, (July 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.7.071117

KEYWORDS: Light scattering, Scattering, Natural surfaces, Tissue optics, Surface roughness, Backscatter, Reflection, Photons, Polarization, Phase shifts

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Proceedings Article | 24 August 2015 Paper

Coherence and polarization of polarization speckle generated by depolarizers and their changes through complex ABCD matrix

Ning Ma, Steen G. Hanson, Tim K. Lee, Mitsuo Takeda, Wei Wang

Proceedings Volume 9660, 96601D (2015) https://doi.org/10.1117/12.2189940

KEYWORDS: Polarization, Speckle, Modulation, Free space, Radio propagation, Statistical analysis, Speckle pattern, Optical components, Ions, Coherence (optics)

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Proceedings Article | 20 March 2015 Paper

Automatic detection and segmentation of vascular structures in dermoscopy images using a novel vesselness measure based on pixel redness and tubularness

Pegah Kharazmi, Harvey Lui, William Stoecker, Tim Lee

Proceedings Volume 9414, 94143M (2015) https://doi.org/10.1117/12.2082720

KEYWORDS: Skin, Image segmentation, Blood vessels, Skin cancer, Independent component analysis, Image processing algorithms and systems, Melanoma, Cancer, RGB color model, Diagnostics

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Proceedings Article | 4 March 2014 Paper

Enhanced diagnostic of skin conditions by polarized laser speckles: phantom studies and computer modeling

Lioudmila Tchvialeva, Tim Lee, Igor Markhvida, Haishan Zeng, Alexander Doronin, Igor Meglinski

Proceedings Volume 8926, 89260X (2014) https://doi.org/10.1117/12.2040192

KEYWORDS: Skin, Speckle, Polarization, Light scattering, Scattering, Speckle pattern, Skin cancer, Optical properties, Monte Carlo methods, Diagnostics

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Proceedings Article | 21 February 2013 Paper

Depolarization of light by rough surface of scattering phantoms

Lioudmila Tchvialeva, Igor Markhvida, Tim Lee, Alexander Doronin, Igor Meglinski

Proceedings Volume 8592, 859217 (2013) https://doi.org/10.1117/12.2002868

KEYWORDS: Scattering, Light scattering, Polarization, Monte Carlo methods, Skin, Tissues, Surface roughness, Natural surfaces, Speckle pattern, Speckle

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SPIE Journal Paper | 12 December 2012 Open Access

Polarization speckle imaging as a potential technique for in vivo skin cancer detection

Lioudmila Tchvialeva, Gurbir Dhadwal, Harvey Lui, Sunil Kalia, Haishan Zeng, David McLean, Tim Lee

JBO, Vol. 18, Issue 06, 061211, (December 2012) https://doi.org/10.1117/12.10.1117/1.JBO.18.6.061211

KEYWORDS: Polarization, Speckle pattern, Skin, Skin cancer, Melanoma, In vivo imaging, Speckle, Speckle imaging, Diagnostics, Raman spectroscopy

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Proceedings Article | 24 February 2012 Paper

Global pattern analysis and classification of dermoscopic images using textons

Maryam Sadeghi, Tim Lee, David McLean, Harvey Lui, M. Stella Atkins

Proceedings Volume 8314, 83144X (2012) https://doi.org/10.1117/12.911818

KEYWORDS: Image classification, Image filtering, Skin, Melanoma, Statistical analysis, Analytical research, Statistical modeling, Cancer, Skin cancer, Dermatology

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Proceedings Article | 23 February 2012 Paper

Multi-level feature extraction for skin lesion segmentation in dermoscopic images

Sina Khakabi, Paul Wighton, Tim Lee, M. Stella Atkins

Proceedings Volume 8315, 83150E (2012) https://doi.org/10.1117/12.911664

KEYWORDS: Image segmentation, Skin, Feature extraction, RGB color model, Machine learning, Image processing algorithms and systems, Melanoma, Cancer, Calibration, Microscopy

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Proceedings Article | 2 February 2012 Paper

Eliminating the effect of bulk scattering when measuring skin surface roughness using speckle contrast: a skin phantom study

Lioudmila Tchvialeva, Igor Markhvida, David McLean, Harvey Lui, Haishan Zeng, Tim Lee

Proceedings Volume 8230, 823004 (2012) https://doi.org/10.1117/12.912255

KEYWORDS: Skin, Scattering, Speckle, Surface roughness, Light scattering, Polarization, Calibration, Signal attenuation, Optical properties, Speckle pattern

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Proceedings Article | 23 November 2011 Paper

Applying laser speckle images to skin science: skin lesion differentiation by polarization

Tim Lee, Lioudmila Tchvialeva, Gurbir Dhadwal, Bahman Sotoodian, Sunil Kalai, Haishan Zeng, Harvey Lui, David McLean

Proceedings Volume 8338, 83381E (2011) https://doi.org/10.1117/12.919976

KEYWORDS: Skin, Polarization, Skin cancer, Speckle, Melanoma, In vivo imaging, Diagnostics, Cancer, Surface roughness, Light sources

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Proceedings Article | 16 June 2011 Paper

Laser speckle contrast vs. depolarization: a solid skin phantom study

Lioudmila Tchvialeva, Gurbir Dhadwal, Diana Diao, Harvey Lui, David McLean, Tim Lee

Proceedings Volume 8090, 809018 (2011) https://doi.org/10.1117/12.890050

KEYWORDS: Speckle, Polarization, Scattering, Skin, Light scattering, Solids, Surface roughness, Tissue optics, Laser scattering, Geometrical optics

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Proceedings Article | 14 September 2010 Paper

Aspects of speckle contrast metrology

L. Tchvialeva, I. Markhvida, T. Lee

Proceedings Volume 7387, 73871U (2010) https://doi.org/10.1117/12.870674

KEYWORDS: Speckle, Cameras, Speckle pattern, Metrology, Tissue optics, Light sources, Error analysis, Metals, CCD cameras, Statistical analysis

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Proceedings Article | 14 September 2010 Paper

Towards automatic detection of malignant melanoma by laser speckle

T. Lee, L. Tchvialeva, H. Lui, H. Zeng, D. McLean

Proceedings Volume 7387, 73871D (2010) https://doi.org/10.1117/12.870692

KEYWORDS: Speckle, Skin, Tissue optics, Melanoma, Light scattering, Scattering, Surface roughness, Skin cancer, Polarization, Speckle pattern

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Proceedings Article | 13 March 2010 Paper

Graph-based pigment network detection in skin images

M. Sadeghi, M. Razmara, M. Ester, T. Lee, M. Atkins

Proceedings Volume 7623, 762312 (2010) https://doi.org/10.1117/12.844602

KEYWORDS: Skin, Visualization, Melanoma, Binary data, Edge detection, Image segmentation, Skin cancer, Feature extraction, Computer aided diagnosis and therapy, Image processing

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Proceedings Article | 13 March 2010 Paper

Segmentation of light and dark hair in dermoscopic images: a hybrid approach using a universal kernel

Nhi Nguyen, Tim Lee, M. Stella Atkins

Proceedings Volume 7623, 76234N (2010) https://doi.org/10.1117/12.844572

KEYWORDS: Image segmentation, Skin, Image processing, Image processing algorithms and systems, Image filtering, Diagnostics, Smoothing, Binary data, Melanoma, Mathematical modeling

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Proceedings Article | 31 December 2009 Paper

Laser speckle and skin cancer: skin roughness assessment

Tim Lee, Lioudmila Tchvialeva, Haishan Zeng, David McLean, Harvey Lui

Proceedings Volume 7388, 738816 (2009) https://doi.org/10.1117/12.854001

KEYWORDS: Skin, Melanoma, Skin cancer, Diagnostics, Surface roughness, Speckle, Polarization, Light scattering, Prototyping, Cancer

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Proceedings Article | 19 February 2009 Paper

Optical discrimination of surface reflection from volume backscattering in speckle contrast for skin roughness measurements

Lioudmila Tchvialeva, Haishan Zeng, Igor Markhvida, Gurbir Dhadwal, Lianne McLean, David McLean, Harvey Lui, Tim Lee

Proceedings Volume 7161, 71610I (2009) https://doi.org/10.1117/12.811916

KEYWORDS: Speckle, Skin, Optical filters, Light scattering, Polarization, Tissue optics, Scattering, Speckle pattern, Reflection, Laser scattering

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SPIE Journal Paper | 1 July 2008 Open Access

Using a zone model to incorporate the influence of geometry on polychromatic speckle contrast

Lioudmila Tchvialeva, Tim Lee, Igor Markhvida, David McLean, Harvey Lui, Haishan Zeng

OE, Vol. 47, Issue 07, 074201, (July 2008) https://doi.org/10.1117/12.10.1117/1.2955797

KEYWORDS: Speckle, Speckle pattern, Light sources, Geometrical optics, Coherence (optics), Diffusers, Surface roughness, Optical engineering, Cancer, Skin cancer

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Proceedings Article | 26 March 2008 Paper

Dermascopic hair disocclusion using inpainting

Paul Wighton, Tim Lee, M. Stella Atkins

Proceedings Volume 6914, 691427 (2008) https://doi.org/10.1117/12.770776

KEYWORDS: Autoregressive models, Image segmentation, Skin, Melanoma, Image processing, Image processing algorithms and systems, Anisotropic diffusion, Personal protective equipment, Cancer, Dermatology

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Proceedings Article | 12 March 2008 Paper

Existence and perception of textural information predictive of atypical nevi: preliminary insights

Paul Wighton, Tim Lee, David McLean, Harvey Lui, M. Stella Atkins

Proceedings Volume 6917, 69170J (2008) https://doi.org/10.1117/12.770793

KEYWORDS: Skin, Melanoma, RGB color model, Statistical analysis, Image segmentation, Cancer, Diagnostics, Fractal analysis, Nonlinear filtering, Human subjects

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Proceedings Article | 15 September 2006 Paper

Geometry influence on polychromatic speckle contrast

Lioudmila Tchvialeva, Tim Lee, Igor Markhvida, David McLean, Harvey Lui, Haishan Zeng

Proceedings Volume 6341, 63411V (2006) https://doi.org/10.1117/12.695470

KEYWORDS: Speckle pattern, Speckle, Light sources, Diffusers, Temporal coherence, Biomedical optics, Coherence (optics), Diffraction, Cancer, Medical research

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Proceedings Article | 12 May 2004 Paper

Automatic nevi segmentation using adaptive mean shift filters and feature analysis

Michael King, Tim Lee, M. Stella Atkins, David McLean

Proceedings Volume 5370, (2004) https://doi.org/10.1117/12.532549

KEYWORDS: Skin, Image segmentation, Image processing, Digital filtering, Image filtering, Melanoma, Diagnostics, Image resolution, Cameras, Medical imaging

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Proceedings Article | 6 June 2000 Paper

New approach to measure border irregularity for melanocytic lesions

Tim Lee, M. Stella Atkins

Proceedings Volume 3979, (2000) https://doi.org/10.1117/12.387728

KEYWORDS: Image segmentation, Fractal analysis, Melanoma, Shape analysis, Image processing, Medical imaging, Skin, Gaussian filters, Image analysis, Convolution

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Proceedings Article | 21 May 1999 Paper

Describing the structural shape of melanocytic lesions

Tim Lee, M. Stella Atkins, Richard Gallagher, Calum MacAulay, Andy Coldman, David McLean

Proceedings Volume 3661, (1999) https://doi.org/10.1117/12.348511

KEYWORDS: Skin, Image segmentation, Shape analysis, Fractal analysis, Computing systems, Image processing, Melanoma, Cameras, Image filtering, Photomasks

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Proceedings Article | 30 September 1996 Paper

Measuring border irregularities of skin lesions using fractal dimensions

Vincent Ng, Tim Lee

Proceedings Volume 2898, (1996) https://doi.org/10.1117/12.253385

KEYWORDS: Fractal analysis, Skin, Image segmentation, Melanoma, Cancer, Medical imaging, RGB color model, Image processing, Skin cancer, Cameras

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Showing 5 of 42 publications

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