Prof. Warren S. Warren Profile

Prof. Warren S. Warren

James B. Duke Professor of Chemistry at Duke Univ

SPIE Involvement:

Conference Program Committee | Author

Publications (39)

Proceedings Article | 13 March 2024 Presentation

A new biomarker for metastatic melanoma based on femtosecond pump-probe microscopy and supervised learning

Angelica Selim, Georgia Beasley, Martin Fischer, Warren Warren, David Grass

Proceedings Volume PC12816, PC128160K (2024) https://doi.org/10.1117/12.2691938

KEYWORDS: Melanoma, Microscopy, Machine learning, Femtosecond phenomena, Tumors, Skin cancer, Pigments, Oncology, Lymph nodes, Gold

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Proceedings Article | 10 August 2023 Presentation

Prospects of pump-probe microscopy for revealing pigment identity and degradation

Martin Fischer, Yue Zhou, Heidi Kastenholz, Michael Topper, David Grass, Warren Warren

Proceedings Volume PC12620, PC1262001 (2023) https://doi.org/10.1117/12.2675050

KEYWORDS: Pigments, Microscopy, Ultrafast phenomena, Pulse signals, Femtosecond pulse shaping, Biological samples, Biological imaging, Absorption, Ultrafast imaging, Spatial resolution

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Proceedings Article | 30 March 2023 Presentation

Identifying metastatic melanoma with pump-probe microscopy of melanin

David Grass, Georgia Beasley, Martin Fischer, M. Angelica Selim, Yue Zhou, Warren Warren

Proceedings Volume PC12392, PC123920F (2023) https://doi.org/10.1117/12.2655705

KEYWORDS: Melanoma, Microscopy, Tumors, Superposition, Polarization control, Nonlinear optics, Nonlinear dynamics, Femtosecond phenomena, Diagnostics

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SPIE Journal Paper | 11 April 2019 Open Access

Unraveling the molecular nature of melanin changes in metastatic cancer

Kuk-Youn Ju, Simone Degan, Martin Fischer, Kevin Zhou, Xiaomeng Jia, Jin Yu, Warren Warren

JBO, Vol. 24, Issue 05, 051414, (April 2019) https://doi.org/10.1117/12.10.1117/1.JBO.24.5.051414

KEYWORDS: Particles, Melanoma, Cancer, Microscopy, Transmission electron microscopy, Oxidation, Hydrogen, Chemical analysis, Skin, Absorption

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Proceedings Article | 4 March 2019 Presentation

Pump-probe imaging illuminates molecular changes in metastatic melanoma (Conference Presentation)

Warren Warren

Proceedings Volume 10882, 108821M (2019) https://doi.org/10.1117/12.2506803

KEYWORDS: Melanoma, Microscopy, Systems modeling, Cancer, Tumor growth modeling

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Proceedings Article | 24 April 2017 Presentation

Melanin-targeted nonlinear microscopy for label-free molecular diagnosis and staining (Conference Presentation)

Warren Warren

Proceedings Volume 10076, 1007603 (2017) https://doi.org/10.1117/12.2256444

KEYWORDS: Systems modeling, Microscopy, Tissue optics, Tissues, Absorption, Chromophores, Light scattering, Scattering, Modulation, Pulsed laser operation

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Proceedings Article | 19 April 2017 Presentation

Stimulated Raman scattering (SRS) spectroscopic OCT (Conference Presentation)

Francisco Robles, Kevin Zhou, Martin Fischer, Warren Warren

Proceedings Volume 10053, 100530X (2017) https://doi.org/10.1117/12.2254829

KEYWORDS: Imaging spectroscopy, Optical coherence tomography, Spectroscopy, Raman spectroscopy, Molecular spectroscopy, Raman scattering, Tissues, Coherence (optics), Multiplexing, Tomography

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Proceedings Article | 27 April 2016 Presentation

Dispersion-based stimulated Raman scattering spectroscopy, holography, and optical coherence tomography (Conference Presentation)

Francisco Robles, Martin Fischer, Warren Warren

Proceedings Volume 9712, 97120J (2016) https://doi.org/10.1117/12.2212875

KEYWORDS: Spectroscopy, Optical coherence tomography, Raman scattering, Raman spectroscopy, Holography, Multiplexing, Optical spectroscopy, Signal processing, Molecular imaging, Imaging spectroscopy

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Proceedings Article | 27 April 2016 Presentation

Diagnosis and staging of female genital tract melanocytic lesions using pump-probe microscopy (Conference Presentation)

Francisco Robles, Maria Selim, Warren Warren

Proceedings Volume 9689, 968903 (2016) https://doi.org/10.1117/12.2212949

KEYWORDS: Melanoma, Microscopy, Metals, Diagnostics, Dental caries, Optical microscopy, Chemical analysis, Biopsy, Tissues, Molecular aggregates

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Proceedings Article | 7 March 2016 Presentation + Paper

Real-time digital signal processing in multiphoton and time-resolved microscopy

Jesse Wilson, Martin Fischer, Warren Warren

Proceedings Volume 9703, 97030O (2016) https://doi.org/10.1117/12.2218102

KEYWORDS: Digital signal processing, Multiphoton microscopy, Microscopy, Field programmable gate arrays, Nonlinear optics, Tissue optics, Signal processing, Time resolved spectroscopy, Linear filtering, Luminescence, Filtering (signal processing)

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Proceedings Article | 26 August 2015 Paper

Separating higher-order nonlinearities in transient absorption microscopy

Jesse Wilson, Jong Kang Park, Miguel Anderson, Martin Fischer, Warren Warren

Proceedings Volume 9584, 95840B (2015) https://doi.org/10.1117/12.2187133

KEYWORDS: Data modeling, Absorption, Signal detection, Rhodamine, Modulation, Microscopy, Field programmable gate arrays, In vivo imaging, Digital signal processing, Tissue optics

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Proceedings Article | 30 June 2015 Paper

Ultrafast pump-probe dynamics of iron oxide based earth pigments for applications to ancient pottery manufacture

Warren Warren, Martin Fischer, Tana Villafana, William Brown

Proceedings Volume 9527, 952709 (2015) https://doi.org/10.1117/12.2184758

KEYWORDS: Hematite, Iron, Microscopy, Oxides, Manufacturing, Absorption, Minerals, Ultrafast phenomena, Spectroscopy, Picosecond phenomena

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Proceedings Article | 5 March 2015 Paper

In vivo pump-probe microscopy of melanoma: characterizing shifts in excited state photodynamics with respect to invasiveness

Jesse Wilson, Simone Degan, Christina Gainey, Sanghamitra Deb, Yasmine Tameze-Rivas, Jennifer Zhang, Warren Warren, Christopher Dall

Proceedings Volume 9329, 93290P (2015) https://doi.org/10.1117/12.2079886

KEYWORDS: Melanoma, Microscopy, In vivo imaging, Tumors, Multiphoton microscopy, Picosecond phenomena, Mouse models, Statistical analysis, Absorption, Skin

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SPIE Journal Paper | 21 November 2014 Open Access

Comparing in vivo pump–probe and multiphoton fluorescence microscopy of melanoma and pigmented lesions

Jesse Wilson, Simone Degan, Christina Gainey, Tanya Mitropoulos, Mary Jane Simpson, Jennifer Zhang, Warren Warren

JBO, Vol. 20, Issue 05, 051012, (November 2014) https://doi.org/10.1117/12.10.1117/1.JBO.20.5.051012

KEYWORDS: In vivo imaging, Melanoma, Tissue optics, Absorption, Confocal microscopy, Multiphoton fluorescence microscopy, Reflectivity, Skin, Multiphoton microscopy, Microscopy

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Proceedings Article | 12 March 2014 Paper

Quantifying melanin distribution using pump-probe microscopy and a 2D morphological autocorrelation transformation for melanoma diagnosis

Francisco Robles, Jesse Wilson, Warren Warren

Proceedings Volume 8949, 89490M (2014) https://doi.org/10.1117/12.2038704

KEYWORDS: Melanoma, Microscopy, Diagnostics, Molecules, Statistical analysis, Chemical analysis, Modulation, Optical parametric oscillators, Molecular imaging, Ultrafast imaging

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SPIE Journal Paper | 2 December 2013 Open Access

Quantifying melanin spatial distribution using pump-probe microscopy and a 2-D morphological autocorrelation transformation for melanoma diagnosis

Francisco Robles, Jesse Wilson, Warren Warren

JBO, Vol. 18, Issue 12, 120502, (December 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.12.120502

KEYWORDS: Melanoma, Microscopy, Statistical analysis, Chemistry, Mathematical morphology, Diagnostics, Molecular imaging, Spatial resolution, Tissues, Laser beam diagnostics

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Proceedings Article | 26 March 2013 Paper

Imaging pigment chemistry in melanocytic conjunctival lesions with pump-probe microscopy

Jesse Wilson, Lejla Vajzovic, Francisco Robles, Thomas Cummings, Prithvi Mruthyunjaya, Warren Warren

Proceedings Volume 8567, 856718 (2013) https://doi.org/10.1117/12.2003137

KEYWORDS: Melanoma, Microscopy, Biopsy, Chemistry, Principal component analysis, Skin, Microscopes, Modulation, In vivo imaging, Multiphoton microscopy

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Proceedings Article | 22 February 2013 Paper

Adapting phasor analysis for nonlinear pump-probe microscopy

Francisco Robles, Jesse Wilson, Martin Fischer, Warren Warren

Proceedings Volume 8589, 858908 (2013) https://doi.org/10.1117/12.2002600

KEYWORDS: Microscopy, Molecules, Terahertz radiation, Statistical analysis, Signal analyzers, Chemistry, Fluorescence lifetime imaging, Biological research, Laser beam diagnostics, Modulation

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Proceedings Article | 22 February 2013 Paper

Optical clearing and multiphoton imaging of paraffin-embedded specimens

Jesse Wilson, Simone Degan, Martin Fischer, Warren Warren

Proceedings Volume 8588, 858813 (2013) https://doi.org/10.1117/12.2003155

KEYWORDS: Lung, Tissues, Second-harmonic generation, Optical clearing, Multiphoton microscopy, Minerals, Spleen, Kidney, Microscopy, Heart

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Proceedings Article | 9 February 2012 Paper

In vivo pump-probe microscopy of melanoma and pigmented lesions

Tanya Mitropoulos, M. Angelica Selim, Jennifer Zhang, Warren Warren, Jesse Wilson, Simone Degan

Proceedings Volume 8226, 822602 (2012) https://doi.org/10.1117/12.908821

KEYWORDS: Melanoma, Microscopy, Skin, Confocal microscopy, In vivo imaging, Multiphoton microscopy, Reflectivity, Absorption, Principal component analysis, Signal detection

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Proceedings Article | 9 June 2011 Paper

Accessing nonlinear phase contrast in biological tissue using femtosecond laser pulse shaping

Kevin Claytor, Martin Fischer, Baolei Li, Prathyush Samineni, Warren Warren

Proceedings Volume 8086, 80860O (2011) https://doi.org/10.1117/12.889668

KEYWORDS: Scanning probe microscopy, Modulation, Scattering, Neurons, Phase contrast, Tissues, Oscillators, Nonlinear optics, Absorption, Phase shift keying

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Proceedings Article | 25 February 2009 Paper

Enhancing two-color absorption, self-phase modulation, and Raman microscopy signatures in tissue with femtosecond laser pulse shaping

Warren Warren, Henry Liu, Thomas Matthews, Dan Fu, Baolei Li, Prathyush Samineni, Ivan Piletic, Martin Fischer

Proceedings Volume 7183, 71830V (2009) https://doi.org/10.1117/12.816488

KEYWORDS: Absorption, Raman spectroscopy, Scanning probe microscopy, Modulation, Oscillators, Tumors, Luminescence, Tissues, Microscopy, Pulse shaping

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SPIE Journal Paper | 1 September 2008 Open Access

Probing skin pigmentation changes with transient absorption imaging of eumelanin and pheomelanin

Dan Fu, Tong Ye, Thomas Matthews, James Grichnik, Lian Hong, John Simon, Warren Warren

JBO, Vol. 13, Issue 05, 054036, (September 2008) https://doi.org/10.1117/12.10.1117/1.2976424

KEYWORDS: Skin, Absorption, Melanoma, Tissues, Signal to noise ratio, Phase shift keying, Thermal effects, Modulation, Laser beam diagnostics, Photothermal effect

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SPIE Journal Paper | 1 July 2008 Open Access

Label-free in vivo optical imaging of microvasculature and oxygenation level

Dan Fu, Thomas Matthews, Tong Ye, Ivan Piletic, Warren Warren

JBO, Vol. 13, Issue 04, 040503, (July 2008) https://doi.org/10.1117/12.10.1117/1.2968260

KEYWORDS: Blood vessels, Absorption, Tumors, Ear, In vivo imaging, Tissues, Laser scanners, Signal to noise ratio, Optical imaging, Hypoxia

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Proceedings Article | 15 February 2008 Paper

Label free high resolution in vivo optical imaging of microvessels

Warren Warren, Dan Fu, Thomas Matthews, Tong Ye

Proceedings Volume 6860, 68601Q (2008) https://doi.org/10.1117/12.763969

KEYWORDS: Absorption, Blood vessels, Ear, In vivo imaging, Tissues, Blood, Image resolution, Tumors, Signal to noise ratio, Laser scanners

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Proceedings Article | 8 February 2008 Paper

Two-photon absorption and transient photothermal imaging of pigments in tissues

Tong Ye, Lian Hong, Thomas Matthews, Warren Warren, John Simon, Dan Fu

Proceedings Volume 6842, 684206 (2008) https://doi.org/10.1117/12.764248

KEYWORDS: Absorption, Skin, Tissues, Picosecond phenomena, Phase shift keying, Modulation, Melanoma, Beam splitters, Microscopes, In vivo imaging

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SPIE Journal Paper | 1 September 2007 Open Access

Two-color, two-photon, and excited-state absorption microscopy

Dan Fu, Tong Ye, Thomas Matthews, Gunay Yurtsever, Warren Warren

JBO, Vol. 12, Issue 05, 054004, (September 2007) https://doi.org/10.1117/12.10.1117/1.2780173

KEYWORDS: Absorption, Modulation, Microscopy, Melanoma, Nonlinear optics, Luminescence, Laser beam diagnostics, Spectroscopy, Pulsed laser operation, Signal processing

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Proceedings Article | 23 March 2007 Paper

Two-color excited-state absorption imaging of melanins

John Simon, Dan Fu, Gunay Yurtsever, Tong Ye, Lian Hong, Thomas Matthews, Warren Warren

Proceedings Volume 6424, 642402 (2007) https://doi.org/10.1117/12.698756

KEYWORDS: Absorption, Tissues, Melanoma, Modulation, Skin, 3D image processing, Microscopes, Laser beam diagnostics, Microscopy, Mode locking

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Proceedings Article | 12 February 2007 Paper

Self-phase modulation and two-photon absorption imaging of cells and active neurons

Henry Liu, Tong Ye, Ryohei Yasuda, Ivan Piletic, Martin Fischer, Warren Warren

Proceedings Volume 6442, 64421J (2007) https://doi.org/10.1117/12.698693

KEYWORDS: Scanning probe microscopy, Absorption, Tissues, Luminescence, Modulation, Neurons, Oscillators, Microscopy, Molecules, Melanoma

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Proceedings Article | 23 February 2006 Paper

Imaging melanin by two-photon absorption microscopy

John Simon, Tong Ye, Warren Warren, Martin Fischer, Gunay Yurtsever

Proceedings Volume 6089, 60891X (2006) https://doi.org/10.1117/12.646139

KEYWORDS: Absorption, Microscopes, Tissues, Luminescence, Melanoma, Microscopy, Skin, Multiphoton fluorescence microscopy, Modulation, Multiphoton microscopy

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Proceedings Article | 16 November 2004 Paper

Direct-detection DWDM and information transmission using infrared acousto-optic femtosecond pulse shaping

Feng Huang, Warren Warren

Proceedings Volume 5579, (2004) https://doi.org/10.1117/12.563513

KEYWORDS: Bragg cells, Signal to noise ratio, Modulation, Dense wavelength division multiplexing, Signal detection, Pulse shaping, Modulators, Picosecond phenomena, Femtosecond phenomena, Receivers

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Proceedings Article | 8 September 2004 Paper

Generation and detection of pulsed T-rays for use in the study of biological and bioterrorism issues

Thomas Jedju, Warren Warren, Todd Kuenstner, Ajay Nahata, Bruno Bosacchi

Proceedings Volume 5411, (2004) https://doi.org/10.1117/12.541531

KEYWORDS: Terahertz radiation, Tissues, Spectroscopy, Terahertz spectroscopy, Picosecond phenomena, Absorption, Molecules, Homeland security, Biomedical optics, Semiconductors

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Proceedings Article | 30 December 2003 Paper

Evolutionary pulse shaping in CARS signal enhancement

Warren Warren, Marlan Scully, Manjusha Mehendale, Bruno Bosacchi

Proceedings Volume 5200, (2003) https://doi.org/10.1117/12.512615

KEYWORDS: Pulse shaping, Femtosecond phenomena, Evolutionary algorithms, Spectroscopy, Pulsed laser operation, Neodymium, Control systems, Optical properties, Bragg cells, Signal processing

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Proceedings Article | 30 December 2003 Paper

Computational intelligence in bacterial spore detection and identification

Manjusha Mehendale, Herschel Rabitz, Bruno Bosacchi, Warren Warren, Marlan Scully

Proceedings Volume 5200, (2003) https://doi.org/10.1117/12.512614

KEYWORDS: Molecules, Raman spectroscopy, Raman scattering, Spectroscopy, Femtosecond phenomena, Chemistry, Neural networks, Resonance enhancement, Genetic algorithms, Fuzzy systems

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Proceedings Article | 6 December 2002 Paper

Spin chaos in magnetic resonance

Yung-Ya Lin, Natalia Lisitza, Susie Huang, Warren Warren

Proceedings Volume 4787, (2002) https://doi.org/10.1117/12.455874

KEYWORDS: Chaos, Magnetism, Amplifiers, Imaging spectroscopy, Spectroscopy, Diffusion, Signal detection, Modulation, Magnetic resonance imaging, Radiation effects

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Proceedings Article | 7 October 1998 Paper

Optical-wavelength-domain code division multiplexing using an AOM-based ultrafast optical pulse-shaping approach

Debabrata Goswami, Warren Warren, Jennifer Davis, Matthew Fetterman, Weiguo Yang

Proceedings Volume 3531, (1998) https://doi.org/10.1117/12.327047

KEYWORDS: Modulation, Ultrafast phenomena, Computer programming, Local area networks, Distortion, Channel projecting optics, Bragg cells, Optical fibers, Terahertz radiation, Optical pulse shaping

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Proceedings Article | 24 April 1998 Paper

New ways to observe and control dynamics

Arjan Buist, Jeffrey Squier, Chris Bardeen, Vladislav Yakovlev, David Fittinghoff, Jian Wei Che, Warren Warren, Christopher Barty, Michiel Mueller, Scott Carpenter, Kent Wilson, Peter Weber, Jianshu Cao, G. Brakenhoff

Proceedings Volume 3273, (1998) https://doi.org/10.1117/12.306130

KEYWORDS: Confocal microscopy, Spatial resolution, Ultrafast phenomena, Temporal resolution, Feedback control, Ultrafast measurement systems, Multiphoton microscopy, Microscopy, Environmental sensing

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Proceedings Article | 10 October 1997 Paper

Terabit-per-second network with spectral-domain modulation

Paul Prucnal, Warren Warren, Hisashi Kobayashi

Proceedings Volume 3231, (1997) https://doi.org/10.1117/12.290449

KEYWORDS: Modulation, Bragg cells, Stars, Time division multiplexing, Network architectures, Picosecond phenomena, Femtosecond phenomena, Modulators, Wavelength division multiplexing, Pulse shaping

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Proceedings Article | 17 June 1994 Paper

Robust approaches to laser-selective chemistry and quantum molecular control

Warren Warren

Proceedings Volume 2124, (1994) https://doi.org/10.1117/12.178096

KEYWORDS: Molecular lasers, Pulsed laser operation, Molecules, Pulse shaping, Acoustics, Chemistry, Modulation, Bragg cells, Picosecond phenomena, Laser applications

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Showing 5 of 39 publications

Conference Committee Involvement (17)

Advanced Chemical Microscopy for Life Science and Translational Medicine 2025

25 January 2025 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine 2024

27 January 2024 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine 2023

28 January 2023 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine 2022

23 January 2022 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine 2021

6 March 2021 | Online Only, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine

1 February 2020 | San Francisco, California, United States

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVII

4 February 2019 | San Francisco, California, United States

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVI

29 January 2018 | San Francisco, California, United States

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV

30 January 2017 | San Francisco, California, United States

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX

15 February 2016 | San Francisco, California, United States

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIII

9 February 2015 | San Francisco, California, United States

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII

3 February 2014 | San Francisco, California, United States

Optical Methods in Drug Discovery and Development II

1 October 2006 | Boston, Massachusetts, United States

Advanced Optical and Quantum Memories and Computing III

24 January 2006 | San Jose, California, United States

Optical Methods in Drug Discovery and Development

23 October 2005 | Boston, MA, United States

Advanced Optical and Quantum Memories and Computing II

25 January 2005 | San Jose, California, United States

Advanced Optical and Quantum Memories and Computing

27 January 2004 | San Jose, CA, United States

Showing 5 of 17 Conference Committees

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