Prof. Wei-Chiang Lin Profile

Prof. Wei-Chiang Lin

SDL Author at Florida International Univ

SPIE Involvement:

Author

Publications (21)

SPIE Journal Paper | 5 February 2013 Open Access

In vivo detection of epileptic brain tissue using static fluorescence and diffuse reflectance spectroscopy

Nitin Yadav, Sanjiv Bhatia, John Ragheb, Rupal Mehta, Prasanna Jayakar, William Yong, Wei-Chiang Lin

JBO, Vol. 18, Issue 02, 027006, (February 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.2.027006

KEYWORDS: Brain, Diffuse reflectance spectroscopy, Luminescence, Epilepsy, Tissue optics, In vivo imaging, Surgery, Tissues, Fluorescence spectroscopy, Hemodynamics

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Proceedings Article | 6 April 2012 Paper

Low-frequency pathophysiological characteristics of pediatric epileptic cortex during the interictal period detected using a dual-wavelength imaging system

Yinchen Song, Prasanna Jayakar, Po-Ching Chen, John Ragheb, Sanjiv Bhatia, Wei-Chiang Lin

Proceedings Volume 8317, 83170V (2012) https://doi.org/10.1117/12.911031

KEYWORDS: Diffuse reflectance spectroscopy, Brain, Epilepsy, Imaging systems, Hemodynamics, Surgery, Solids, In vivo imaging, Blood vessels, Functional magnetic resonance imaging

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SPIE Journal Paper | 1 November 2010 Open Access

Diffuse reflectance spectroscopy for in vivo pediatric brain tumor detection

Wei-Chiang Lin, David Sandberg, Sanjiv Bhatia, Mahlon Johnson, Sanghoon Oh, John Ragheb

JBO, Vol. 15, Issue 06, 061709, (November 2010) https://doi.org/10.1117/12.10.1117/1.3505012

KEYWORDS: Tumors, Brain, Diffuse reflectance spectroscopy, In vivo imaging, Tissues, Cerebral cortex, Statistical analysis, Tissue optics, Surgery, Spectroscopy

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SPIE Journal Paper | 1 May 2010 Open Access

In vivo characterization of myocardial infarction using fluorescence and diffuse reflectance spectroscopy

Yalin Ti, Po-Ching Chen, Wei-Chiang Lin

JBO, Vol. 15, Issue 03, 037009, (May 2010) https://doi.org/10.1117/12.10.1117/1.3442505

KEYWORDS: Tissues, Diffuse reflectance spectroscopy, Luminescence, In vivo imaging, Tissue optics, Heart, Inflammation, Statistical analysis, Optical spectroscopy, Fluorescence spectroscopy

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Proceedings Article | 25 April 2009 Paper

Differentiating pediatric epileptic brain tissue from normal brain tissue by using time-dependent diffuse reflectance spectroscopy in vivo: comprehensive data analysis method in the time domain

Sanghoon Oh, Bradley Fernald, Sanjiv Bhatia, David Sandberg, John Ragheb, Wei-Chiang Lin, Mahlon Johnson

Proceedings Volume 7313, 73130M (2009) https://doi.org/10.1117/12.818767

KEYWORDS: Brain, Tissue optics, Diffuse reflectance spectroscopy, Epilepsy, Data analysis, Tissues, Tumors, Control systems, Statistical analysis, In vivo imaging

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This research investigated the feasibility of using time-dependent diffuse reflectance spectroscopy to differentiate pediatric epileptic brain tissue from normal brain tissue. The optical spectroscopic technique monitored the dynamic optical properties of the cerebral cortex that are associated with its physiological, morphological, and compositional characteristics. Due to the transient irregular epileptic discharge activity within the epileptic brain tissue it was hypothesized that the lesion would express abnormal dynamic optical behavior that would alter normal dynamic behavior. Thirteen pediatric epilepsy patients and seven pediatric brain tumor patients (normal controls) were recruited for this clinical study. Dynamic optical properties were obtained from the cortical surface intraoperatively using a timedependent diffuse reflectance spectroscopy system. This system consisted of a fiber-optic probe, a tungsten-halogen light source, and a spectrophotometer. It acquired diffuse reflectance spectra with a spectral range of 204 nm to 932 nm at a rate of 33 spectra per second for approximately 12 seconds. Biopsy samples were taken from electrophysiologically abnormal cortex and evaluated by a neuropathologist, which served as a gold standard for lesion classification. For data analysis, spectral intensity changes of diffuse reflectance in the time domain at two different wavelengths from each investigated site were compared. Negative correlation segment, defined by the periods where the intensity changes at the two wavelengths were opposite in their slope polarity, were extracted. The total duration of negative correlation, referred to as the "negative correlation time index", was calculated by integrating the negative correlation segments. The negative correlation time indices from all investigated sites were sub-grouped according to the corresponding histological classifications. The difference between the mean indices of two subgroups was evaluated by standard t-test. These comparison and calculation procedures were carried out for all possible wavelength combinations between 400 nm and 800 nm with 2 nm increments. The positive group consisted of seven pathologically abnormal test sites, and the negative group consisted of 13 normal test sites from non-epileptic tumor patients. A standard t-test showed significant difference between negative correlation time indices from the two groups at the wavelength combinations of 700-760 nm versus 550-580 nm. An empirical discrimination algorithm based on the negative correlation time indices in this range produced 100% sensitivity and 85% specificity. Based on these results time-dependent diffuse reflectance spectroscopy with optimized data analysis methods differentiates epileptic brain tissue from normal brain tissue adequately, therefore can be utilized for surgical guidance, and may enhance the surgical outcome of pediatric epilepsy surgery.

SPIE Journal Paper | 1 January 2009 Open Access

Optical spectroscopy for in-vitro differentiation of pediatric neoplastic and epileptogenic brain lesions

Wei-Chiang Lin, David Sandberg, Sanjiv Bhatia, Mahlon Johnson, Glenn Morrison, John Ragheb

JBO, Vol. 14, Issue 01, 014028, (January 2009) https://doi.org/10.1117/12.10.1117/1.3080144

KEYWORDS: Brain, Luminescence, Diffuse reflectance spectroscopy, In vitro testing, Tissues, Tumors, Optical spectroscopy, Tissue optics, Epilepsy, Spectroscopy

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Proceedings Article | 26 February 2008 Paper

Time-dependent diffuse reflectance spectroscopy for in vivo characterization of pediatric epileptogenic brain lesions

Mahlon Johnson, Wei-Chiang Lin, Bradley Fernald, Sanjiv Bhatia, Sanghoon Oh, John Ragheb, David Sandberg

Proceedings Volume 6842, 68422M (2008) https://doi.org/10.1117/12.763407

KEYWORDS: Diffuse reflectance spectroscopy, Brain, Epilepsy, In vivo imaging, Tissues, Surgery, Fiber optics, Tumors, Tissue optics, Linear filtering

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Proceedings Article | 23 March 2007 Paper

In vivo optical characterization of pediatric epileptogenic lesions

S. Bhatia, M. Duchowny, A. Fernandez, J. Ragheb, D. Sandberg, G. Morrison, Mahlon Johnson, P. Jayakar, W.-C. Lin

Proceedings Volume 6424, 642427 (2007) https://doi.org/10.1117/12.700717

KEYWORDS: Brain, Luminescence, Diffuse reflectance spectroscopy, In vivo imaging, Epilepsy, Electroencephalography, Tissue optics, Spectroscopy, Optical spectroscopy, Surgery

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Proceedings Article | 7 February 2007 Paper

In vivo optical detection of brain tumor and tumor margin: a combined autofluorescence and diffuse reflectance spectroscopic study

Anita Mahadevan-Jansen, Shovan Majumder, Steven Gebhart, Mahlon Johnson, Reid Thompson, Kyle Weaver, Wei-Chiang Lin

Proceedings Volume 6430, 64300F (2007) https://doi.org/10.1117/12.724875

KEYWORDS: Tumors, Brain, Tissues, Diffuse reflectance spectroscopy, Algorithm development, Diagnostics, In vivo imaging, Spectroscopy, Luminescence, Reflectance spectroscopy

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Proceedings Article | 22 November 2005 Paper

Decline in NAD(P)H autofluorescence precedes apoptotic cell death from chemotherapy

Osman Muhammad, Steven Toms, Heather Jackson, Wei-Chiang Lin

Proceedings Volume 6009, 60090Q (2005) https://doi.org/10.1117/12.630711

KEYWORDS: Luminescence, Cell death, Tissue optics, Tumors, Tissues, Fluorescence spectroscopy, Mass spectrometry, Spectroscopy, Optical spectroscopy, Magnetic resonance imaging

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SPIE Journal Paper | 1 September 2004 Open Access

In vivo assessment of thermal damage in the liver using optical spectroscopy

Clay Buttemere, Ravi Chari, Christopher Anderson, Kay Washington, Anita Mahadevan-Jansen, Wei-Chiang Lin

JBO, Vol. 9, Issue 05, (September 2004) https://doi.org/10.1117/12.10.1117/1.1779627

KEYWORDS: Luminescence, Tissues, Diffuse reflectance spectroscopy, Tissue optics, Liver, In vivo imaging, Blood, Absorption, In vitro testing, Spectroscopy

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Proceedings Article | 22 July 2003 Paper

Feedback control of liver thermotherapy using optical spectroscopy

Clay Buttemere, Ravi Chari, Christopher Anderson, Anita Mahadevan-Jansen, Wei-Chiang Lin

Proceedings Volume 4958, (2003) https://doi.org/10.1117/12.479803

KEYWORDS: Tissues, Luminescence, Liver, Tissue optics, Diffuse reflectance spectroscopy, In vivo imaging, In vitro testing, Heat therapy, Thermal modeling, Tumors

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Proceedings Article | 2 July 2003 Paper

Characterization of a spectral imaging system

Wei-Chiang Lin, Anita Mahadevan-Jansen, Steven Gebhart

Proceedings Volume 4959, (2003) https://doi.org/10.1117/12.479856

KEYWORDS: Imaging systems, Imaging spectroscopy, Luminescence, Tumors, Spatial resolution, Tissue optics, Spectral resolution, Tissues, Brain, Calibration

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SPIE Journal Paper | 1 April 2003 Open Access

Feasibility study using surface-enhanced Raman spectroscopy for the quantitative detection of excitatory amino acids

Patrick O'Neal, Massoud Motamedi, Jefferson Chen, Gerard Coté, Wei-Chiang Lin

JBO, Vol. 8, Issue 02, (April 2003) https://doi.org/10.1117/12.10.1117/1.1563261

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SPIE Journal Paper | 1 January 2003 Open Access

Feasibility study using surface-enhanced Raman spectroscopy for the quantitative detection of excitatory amino acids

Patrick O'Neal, Massoud Motamedi, Wei-Chiang Lin, Jefferson Chen, Gerard Cote

JBO, Vol. 8, Issue 01, (January 2003) https://doi.org/10.1117/12.10.1117/1.1528208

KEYWORDS: Surface enhanced Raman spectroscopy, Silver, Brain, Raman spectroscopy, Particles, Injuries, Head, In vivo imaging, Microfluidics, Calibration

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Proceedings Article | 2 July 2001 Paper

Brain tissue charcterization using spectral imaging: a potential clinical tool

E. Duco Jansen, Anita Mahadevan-Jansen, David Mongin, Dawn Pedrotty, Wei-Chiang Lin

Proceedings Volume 4259, (2001) https://doi.org/10.1117/12.432484

KEYWORDS: Brain, Tissues, Imaging spectroscopy, Tumors, Luminescence, Neuroimaging, Imaging systems, Tissue optics, Data acquisition, Optical spectroscopy

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Proceedings Article | 4 June 2001 Paper

Intraoperative spectroscopic-guided brain tumor resection: reduction of blood contamination effects on tissue optical spectra

Anita Mahadevan-Jansen, Wei-Chiang Lin, E. Duco Jansen

Proceedings Volume 4254, (2001) https://doi.org/10.1117/12.427932

KEYWORDS: Blood, Tissue optics, Luminescence, Contamination, Tumors, Brain, Diffuse reflectance spectroscopy, Tissues, Monte Carlo methods, Optical spectroscopy

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Proceedings Article | 3 May 2000 Paper

Spectroscopic-guided brain tumor resection

Anita Mahadevan-Jansen, Steven Toms, E. Duco Jansen, Wei-Chiang Lin

Proceedings Volume 3911, (2000) https://doi.org/10.1117/12.384896

KEYWORDS: Tumors, Brain, Tissues, Electroluminescence, Luminescence, Diffuse reflectance spectroscopy, Spectroscopy, In vivo imaging, Optical spectroscopy, Algorithm development

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SPIE Journal Paper | 1 April 2000 Open Access

Brain tumor demarcation using optical spectroscopy: an in vitro study

Wei-Chiang Lin, Steven Toms, Massoud Motamedi, E. Duco Jansen, Anita Mahadevan-Jansen

JBO, Vol. 5, Issue 02, (April 2000) https://doi.org/10.1117/12.10.1117/1.429989

KEYWORDS: Brain, Tumors, Tissues, Luminescence, Diffuse reflectance spectroscopy, Algorithm development, In vitro testing, Reflectivity, Optical spectroscopy, Spectroscopy

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Proceedings Article | 16 June 1997 Paper

Thermally induced refractive nonlinearity in scattering media

Massoud Motamedi, James Wicksted, Wei-Chiang Lin, Ashley Welch

Proceedings Volume 2975, (1997) https://doi.org/10.1117/12.275512

KEYWORDS: Scattering, Laser scattering, Transmittance, Light scattering, Monte Carlo methods, Thermal effects, Laser therapeutics, Laser tissue interaction, Pulsed laser operation, Laser energy

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Proceedings Article | 17 August 1994 Paper

Dynamics of tissue reflectance and transmittance during laser irradiation

Ashley Welch, Wei-Chiang Lin, Massoud Motamedi

Proceedings Volume 2134, (1994) https://doi.org/10.1117/12.182947

KEYWORDS: Tissues, Transmittance, Reflectivity, Laser irradiation, Optical properties, Argon, Nd:YAG lasers, Natural surfaces, High power lasers, Tissue optics

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Showing 5 of 21 publications

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