Plasmon-enhanced Electronic and Vibrational Raman Spectroscopy in multiresonant nanolaminate nano-optoelectrodes enables monitoring of voltage-driven Faradaic and non-Faradaic processes at electrode-electrolyte interfaces, paving the way for advances in optical voltage biosensing, hybrid electronics-photonics signal transduction, and interfacial electrochemical monitoring.
Despite its ultrasensitive detection capability, surface-enhanced Raman spectroscopy (SERS) faces challenges as a quantitative biochemical analysis due to the significant dependence of local field enhancement on nanoscale geometric variations. Significant efforts have been devoted to develop SERS calibration methods by introducing Raman tags as internal standards. Raman tags undergo similar SERS enhancement, and ratiometric signals for target analytes can be generated with reduced SERS enhancement variations. However, using Raman tags still faces challenges for label-free applications, including spatial competition between the analyte and tags in hotspots, spectral interference, limited long-term stability due to laser-induced photo-degradation. We demonstrate that electronic Raman scattering (ERS) signals from metallic nanostructures at hotspots can serve as the internal calibration standard to enable quantitative SERS analysis and improve biostatistical analysis. ERS is omnipresent in any plasmonic construct and shown as a broad continuous background in SERS measurements. Both ERS and SERS processes experience the |E|4 local enhancements during the excitation and inelastic scattering transitions. We demonstrate that ERS-calibrated SERS signals are insensitive to variations from different hotspots and thus can enable more accurate quantitative SERS analysis. For validation, we performed label-free SERS analysis of living biological systems using four different cancer cell lines cultured on SERS devices and their drug responses. Remarkably, after ERS calibration, the statistical scatter plots are more similar to the intrinsic biological properties of cancer subtype categorization and their known drug responses. Therefore, we envision that ERS calibrated SERS can find crucial opportunities in label-free molecular profiling of complicated biological systems.
Plasmonic nanocavities can control light flows and enhance light-mater interactions at subwavelength scale, and thus can potentially be used as nanoscale components in integrated optics systems either for passive optical coupling, or for active optical modulation and emission. In this work, we investigated a new type of multilayered metal-insulator optical nanocavities that can support multiple localized plasmon resonances with ultra-small mode volumes. The total number of resonance peaks and their resonance wavelengths can be freely and accurately controlled by simple geometric design rules. Multi-resonance plasmonic nanocavities can serve as a nanoscale wavelength-multiplexed optical components in integrated optics systems, such as optical couplers, light emitters, nanolasers, optical sensors, and optical modulators.
We report our recent development in pursuing high Quality-Factor (high-Q factor) plasmonic resonances, with vertically
aligned two dimensional (2-D) periodic nanorod arrays. The 2-D vertically aligned nano-antenna array can have high-Q
resonances varying arbitrarily from near infrared to terahertz regime, as the antenna resonances of the nanorod are highly
tunable through material properties, the length of the nanorod, and the orthogonal polarization direction with respect to
the lattice surface,. The high-Q in combination with the small optical mode volume gives a very high Purcell factor,
which could potentially be applied to various enhanced nonlinear photonics or optoelectronic devices. The 'hot spots'
around the nanorods can be easily harvested as no index-matching is necessary. The resonances maintain their high-Q
factor with the change of the environmental refractive index, which is of great interest for molecular sensing.
Conference Committee Involvement (10)
Organic Photonic Materials and Devices XXV
1 February 2023 | San Francisco, California, United States
Organic Photonic Materials and Devices XXIV
26 January 2022 | San Francisco, California, United States
Organic Photonic Materials and Devices XXIII
6 March 2021 | Online Only, California, United States
Organic Photonic Materials and Devices XXII
5 February 2020 | San Francisco, California, United States
Integrated Optics: Devices, Materials, and Technologies XXIV
3 February 2020 | San Francisco, California, United States
Organic Photonic Materials and Devices XXI
5 February 2019 | San Francisco, California, United States
Integrated Optics: Devices, Materials, and Technologies XXIII
4 February 2019 | San Francisco, California, United States
Organic Photonic Materials and Devices XX
31 January 2018 | San Francisco, California, United States
Integrated Optics: Devices, Materials, and Technologies XXII
29 January 2018 | San Francisco, California, United States
Organic Photonic Materials and Devices XIX
30 January 2017 | San Francisco, California, United States
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