Dr. William W. Mantulin Profile

Dr. William W. Mantulin

Adjunct Professor at Beckman Laser Institute and Medical Clinic

SPIE Involvement:

Author

Publications (24)

Proceedings Article | 25 March 2013 Open Access

Open Access

Paper

Development of quality control and instrumentation performance metrics for diffuse optical spectroscopic imaging instruments in the multi-center clinical environment

Samuel Keene, Albert Cerussi, Robert Warren, Brian Hill, Darren Roblyer, Anaїs Leproux, Amanda Durkin, Thomas O'Sullivan, Hosain Haghany, William Mantulin, Bruce Tromberg

Proceedings Volume 8578, 85782M (2013) https://doi.org/10.1117/12.2008009

KEYWORDS: Diodes, Tumors, Tissue optics, Diffuse optical imaging, Optical imaging, Optical spectroscopy, Data processing, Imaging spectroscopy, Optical spectroscopy imaging, Spectroscopes

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SPIE Journal Paper | 8 November 2012 Open Access

Open Access

Deep tissue fluorescence imaging and in vivo biological applications

Viera Crosignani, Alexander Dvornikov, Jose Aguilar, Chiara Stringari, Robert Edwards, William Mantulin, Enrico Gratton

JBO, Vol. 17, Issue 11, 116023, (November 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.11.116023

KEYWORDS: Luminescence, Photons, In vivo imaging, Tissues, Tissue optics, Colon, Sensors, Stem cells, Intestine, Microscopes

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Proceedings Article | 9 February 2012 Paper

Paper

In vivo deep tissue fluorescence imaging of the murine small intestine and colon

Viera Crosignani, Alexander Dvornikov, Jose Aguilar, Chiara Stringari, Roberts Edwards, Williams Mantulin, Enrico Gratton

Proceedings Volume 8226, 822609 (2012) https://doi.org/10.1117/12.912841

KEYWORDS: Luminescence, Colon, Intestine, Tissues, Sensors, In vivo imaging, Deep tissue imaging, Stem cells, Microscopes, Imaging systems

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SPIE Journal Paper | 1 March 2010 Open Access

Open Access

Scanning laser image correlation for measurement of flow

Molly Rossow, William Mantulin, Enrico Gratton

JBO, Vol. 15, Issue 02, 026003, (March 2010) https://doi.org/10.1117/12.10.1117/1.3365946

KEYWORDS: Particles, Microfluidics, Velocity measurements, Blood vessels, Speckle, Blood circulation, Microscopes, Blood, Diffusion, Laser scanners

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Proceedings Article | 25 February 2010 Open Access

Open Access

Paper

Quality control and assurance for validation of DOS/I measurements

Albert Cerussi, Amanda Durkin, Richard Kwong, Timothy Quang, Brian Hill, Bruce Tromberg, Nick MacKinnon, William Mantulin

Proceedings Volume 7567, 756703 (2010) https://doi.org/10.1117/12.842755

KEYWORDS: Calibration, Data acquisition, Databases, Breast, Standards development, Clinical trials, Optical imaging, Breast cancer, Data archive systems, Optical properties

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SPIE Journal Paper | 1 March 2009 Open Access

Open Access

Spatiotemporal image correlation spectroscopy measurements of flow demonstrated in microfluidic channels

Molly Rossow, William Mantulin, Enrico Gratton

JBO, Vol. 14, Issue 02, 024014, (March 2009) https://doi.org/10.1117/12.10.1117/1.3088203

KEYWORDS: Blood vessels, Blood circulation, Particles, Imaging spectroscopy, Speckle, Blood, Spectroscopy, Doppler effect, Velocity measurements, Microfluidics

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SPIE Journal Paper | 1 January 2009 Open Access

Open Access

Book Review: Handbook of Biomedical Nonlinear Optical Microscopy

William Mantulin, Barry Masters, Peter So

JBO, Vol. 14, Issue 01, 019901, (January 2009) https://doi.org/10.1117/12.10.1117/1.3077566

KEYWORDS: Microscopy, Biomedical optics, Luminescence, Optical microscopy, Harmonic generation, Optical spectroscopy, Multiphoton microscopy, Tissues, Spectroscopy, Spectroscopes

SPIE Journal Paper | 1 November 2006 Open Access

Open Access

Effects of vasodilation on intrinsic optical signals in the mammalian brain: a phantom study

Kandice Tanner, Erin Beitel, Enrico D'Amico, William Mantulin, Enrico Gratton

JBO, Vol. 11, Issue 06, 064020, (November 2006) https://doi.org/10.1117/12.10.1117/1.2398920

KEYWORDS: Scattering, Absorption, Opacity, Brain, Tissue optics, Absorbance, Chromophores, Tissues, Intrinsic optical signal, Blood vessels

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SPIE Journal Paper | 1 November 2005 Open Access

Open Access

Spectrally resolved neurophotonics: a case report of hemodynamics and vascular components in the mammalian brain

Kandice Tanner, Enrico D'Amico, Amy Kaczmarowski, Shwayta Kukreti, Joe Malpeli, William Mantulin, Enrico Gratton

JBO, Vol. 10, Issue 06, 064009, (November 2005) https://doi.org/10.1117/12.10.1117/1.2137291

KEYWORDS: Scattering, Tissues, Visualization, Brain, Tissue optics, Hemodynamics, Visual cortex, Light scattering, Sensors, Spectroscopy

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SPIE Journal Paper | 1 November 2004 Open Access

Open Access

Mitigating thermal mechanical damage potential during two-photon dermal imaging

Barry Masters, Peter So, Christof Buehler, Nicholas Barry, Jason Sutin, William Mantulin, Enrico Gratton

JBO, Vol. 9, Issue 06, (November 2004) https://doi.org/10.1117/12.10.1117/1.1806135

KEYWORDS: Pulsed laser operation, Skin, Two photon imaging, Absorption, Laser energy, Cavitation, Luminescence, Laser damage threshold, In vivo imaging, Infrared radiation

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SPIE Journal Paper | 1 January 2004 Open Access

Open Access

Noninvasive determination of the optical properties of adult brain: near-infrared spectroscopy approach

Jee Choi, Martin Wolf, Vladislav Toronov, Ursula Wolf, Chiara Polzonetti, Dennis Hueber, Larisa Safonova, Rajarsi Gupta, Antonios Michalos, William Mantulin, Enrico Gratton

JBO, Vol. 9, Issue 01, (January 2004) https://doi.org/10.1117/12.10.1117/1.1628242

KEYWORDS: Brain, Optical properties, Oxygen, Sensors, Head, Absorption, Tissue optics, Scattering, Near infrared spectroscopy, Skull

Proceedings Article | 18 August 1997 Paper

Paper

Optical study of the skeletal muscle during exercise with a second-generation frequency-domain tissue oximeter

Maria-Angela Franceschini, Don Wallace, Beniamino Barbieri, Sergio Fantini, William Mantulin, Simone Pratesi, Gian Paolo Donzelli, Enrico Gratton

Proceedings Volume 2979, (1997) https://doi.org/10.1117/12.280229

KEYWORDS: Tissue optics, Prototyping, Oximeters, Light emitting diodes, Semiconductor lasers, Light sources, In vivo imaging, Tissues, Electronics, Optical fibers

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Proceedings Article | 18 August 1997 Paper

Paper

Chromophore detection by fluorescence spectroscopy in tissue-like phantoms

Albert Cerussi, Sergio Fantini, John Maier, William Mantulin, Enrico Gratton

Proceedings Volume 2979, (1997) https://doi.org/10.1117/12.280240

KEYWORDS: Luminescence, Tissues, Fluorescence spectroscopy, Absorption, Rhodamine, Scattering, Tissue optics, Spectroscopy, Diffusion, Interference filters

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Proceedings Article | 23 May 1997 Open Access

Open Access

Paper

Cell damage in UVA and cw/femtosecond NIR microscopes

Karsten Koenig, Hong Liang, Sol Kimel, Lars Svaasand, Bruce Tromberg, Tatiana Krasieva, Michael Berns, Karl-Juergen Halbhuber, Peter So, William Mantulin, Enrico Gratton

Proceedings Volume 2983, (1997) https://doi.org/10.1117/12.274337

KEYWORDS: Near infrared, Femtosecond phenomena, Microscopes, Continuous wave operation, Luminescence, Objectives, Absorption, Optical tweezers, Microscopy, Cell death

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Proceedings Article | 6 December 1996 Paper

Paper

Cell damage in two-photon microscopes

Karsten Koenig, Peter So, William Mantulin, Enrico Gratton

Proceedings Volume 2926, (1996) https://doi.org/10.1117/12.260794

KEYWORDS: Near infrared, Femtosecond phenomena, Luminescence, Microscopes, Photons, Objectives, Microscopy, Nondestructive evaluation, Plasma, 3D image processing

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Proceedings Article | 15 January 1996 Open Access

Open Access

Paper

Two-photon excited cellular autofluorescence induced by cw and femtosecond NIR microradiation

Karsten Koenig, Peter So, William Mantulin, Enrico Gratton, Tatiana Krasieva, Michael Berns, Bruce Tromberg

Proceedings Volume 2628, (1996) https://doi.org/10.1117/12.229988

KEYWORDS: Luminescence, Near infrared, Continuous wave operation, Laser scanners, Absorption, Femtosecond phenomena, Microscopes, Optical tweezers, Auto-fluorescence imaging

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Proceedings Article | 30 May 1995 Paper

Paper

Multichannel optical instrument for near-infrared imaging of tissue

Maria-Angela Franceschini, Sergio Fantini, Scott Walker, John Maier, William Mantulin, Enrico Gratton

Proceedings Volume 2389, (1995) https://doi.org/10.1117/12.209975

KEYWORDS: Scattering, Optical properties, Absorption, Sensors, Tissue optics, Modulation, Optical spheres, Light sources, Glasses, Light scattering

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Proceedings Article | 1 May 1995 Paper

Paper

Tissue optical parameter map generated with frequency-domain spectroscopy

William Mantulin, Sergio Fantini, Maria Angela Franceschini, Scott Walker, John Maier, Enrico Gratton

Proceedings Volume 2396, (1995) https://doi.org/10.1117/12.208420

KEYWORDS: Tissue optics, Scattering, Geometrical optics, Light scattering, Absorption, Sensors, Modulation, Image processing, Optical imaging, Spectroscopy

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Proceedings Article | 12 April 1995 Paper

Paper

In vivo study of human tissues with a portable near-IR tissue spectrometer

John Maier, Beniamino Barbieri, Arun Chervu, Indira Chervu, Sergio Fantini, Maria-Angela Franceschini, Moshe Levi, William Mantulin, Adam Rosenberg, Scott Walker, Enrico Gratton

Proceedings Volume 2387, (1995) https://doi.org/10.1117/12.206828

KEYWORDS: Tissues, Blood, Sensors, Absorption, Spectroscopy, Scattering, Ischemia, Vascular diseases, In vivo imaging, Head

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Proceedings Article | 28 June 1994 Paper

Paper

Spectroscopic innovations at the laboratory for fluorescence dynamics

William Mantulin, Enrico Gratton

Proceedings Volume 2100, (1994) https://doi.org/10.1117/12.178995

KEYWORDS: Luminescence, Sensors, Microchannel plates, Modulation, Signal processing, Fluorescence spectroscopy, Signal detection, Biological research, Heterodyning, Phase shift keying

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Proceedings Article | 28 June 1994 Paper

Paper

Absorption spectra of a chromophore in highly scattering media

Sergio Fantini, Maria-Angela Franceschini, Joshua Fishkin, William Mantulin, Enrico Gratton

Proceedings Volume 2100, (1994) https://doi.org/10.1117/12.178989

KEYWORDS: Scattering, Absorption, Light scattering, Modulation, Tissue optics, Diffusion, Chromophores, Tissues, Diodes, Optical properties

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Proceedings Article | 14 September 1993 Paper

Paper

Quantitative diffusive wave spectroscopy in tissues

William Mantulin, Joshua Fishkin, Peter So, Enrico Gratton, John Maier

Proceedings Volume 1888, (1993) https://doi.org/10.1117/12.154661

KEYWORDS: Absorption, Scattering, Modulation, Tissues, Photons, Phase shift keying, Scattering media, Light scattering, Spectroscopy, Diffusion

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Proceedings Article | 7 July 1993 Paper

Paper

Optical imaging in the frequency domain

William Mantulin, Todd French, Enrico Gratton

Proceedings Volume 1892, (1993) https://doi.org/10.1117/12.147495

KEYWORDS: Modulation, Sensors, Phase shift keying, Cameras, Laser systems engineering, Microchannel plates, Phase shifts, Image intensifiers, Imaging systems, Heterodyning

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Proceedings Article | 1 May 1991 Paper

Paper

Diffusion of intensity modulated near-infrared light in turbid media

Joshua Fishkin, Enrico Gratton, Martin vandeVen, William Mantulin

Proceedings Volume 1431, (1991) https://doi.org/10.1117/12.44184

KEYWORDS: Modulation, Scattering, Signal detection, Diffusion, Imaging spectroscopy, Particles, Light scattering, Time resolved spectroscopy, Tissues, Absorption

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Showing 5 of 24 publications

Conference Committee Involvement (3)

Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III

22 January 2011 | San Francisco, California, United States

Design and Performance Validation of Phantoms used in Conjunction with Optical Measurement of Tissue

23 January 2010 | San Francisco, California, United States

Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurements of Tissue

19 January 2008 | San Jose, California, United States

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