Prof. William M. Whelan Profile

Prof. William M. Whelan

Professor at Univ of Prince Edward Island

SPIE Involvement:

Author

Area of Expertise:

laser therapeutics , optoacoustics , optical spectroscopy , Raman spectroscopy , Optofluidics

Publications (23)

SPIE Journal Paper | 9 May 2014 Open Access

Optoacoustic characterization of prostate cancer in an in vivo transgenic murine model

Michelle Patterson, Christopher Riley, Michael Kolios, William Whelan

JBO, Vol. 19, Issue 05, 056008, (May 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.5.056008

KEYWORDS: Tumors, Tissues, Control systems, Signal attenuation, Prostate, Prostate cancer, Ultrasonography, Tumor growth modeling, Transducers, In vivo imaging

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SPIE Journal Paper | 1 May 2014 Open Access

Feasibility of interstitial near-infrared radiance spectroscopy platform for ex vivo canine prostate studies: optical properties extraction, hemoglobin and water concentration, and gold nanoparticles detection

Serge Grabtchak, Logan Montgomery, William Whelan

JBO, Vol. 19, Issue 05, 057003, (May 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.5.057003

KEYWORDS: Prostate, Gold, Tissues, Absorption, Optical properties, Spectroscopy, Scattering, Chromophores, In vivo imaging, Nanoparticles

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SPIE Journal Paper | 17 July 2013 Open Access

Optical detection of gold nanoparticles in a prostate-shaped porcine phantom

Serge Grabtchak, Elena Tonkopi, William Whelan

JBO, Vol. 18, Issue 07, 077005, (July 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.7.077005

KEYWORDS: Gold, Sensors, Tissues, Nanoparticles, Target detection, Tissue optics, Prostate, Biomedical optics, Plasmons, Absorption

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Proceedings Article | 29 March 2013 Paper

Interstitial detection of gold nanoparticles in deep tissues with optical radiance using porcine phantom

Serge Grabtchak, Elena Tonkopi, William Whelan

Proceedings Volume 8672, 86721E (2013) https://doi.org/10.1117/12.2008962

KEYWORDS: Gold, Tissues, Nanoparticles, Spectroscopy, Plasmons, Tissue optics, Prostate, Sensors, Absorption, Diagnostics

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SPIE Journal Paper | 8 June 2012 Open Access

Experimental spectro-angular mapping of light distribution in turbid media

Serge Grabtchak, Tyler Palmer, Florian Foschum, Andre Liemert, Alwin Kienle, William Whelan

JBO, Vol. 17, Issue 06, 067007, (June 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.6.067007

KEYWORDS: Scattering, Absorption, Tissues, Tissue optics, Light scattering, Sensors, Signal attenuation, Photons, Distance measurement, Diagnostics

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Proceedings Article | 8 May 2012 Paper

Spectro-angular mapping of localized gold inclusions in Intralipid phantoms

Serge Grabtchak, Tyler Palmer, William Whelan

Proceedings Volume 8427, 84271R (2012) https://doi.org/10.1117/12.927986

KEYWORDS: Gold, Sensors, Optical testing, Spectroscopy, Absorption, Mineralogy, Prostate, Scattering, Target detection, Nanoparticles

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Proceedings Article | 23 February 2012 Paper

Frequency analysis of optoacoustic signals in laser heated tissues

Annie Ladéroute, Michelle Patterson, Michael Kolios, William Whelan

Proceedings Volume 8223, 822341 (2012) https://doi.org/10.1117/12.910217

KEYWORDS: Tissues, Transducers, Laser therapeutics, Ultrasonography, Calibration, Spectral calibration, Signal analyzers, Semiconductor lasers, Pulsed laser operation, Natural surfaces

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SPIE Journal Paper | 1 July 2011 Open Access

Detection of localized inclusions of gold nanoparticles in Intralipid-1% by point-radiance spectroscopy

Serge Grabtchak, Tyler Palmer, William Whelan

JBO, Vol. 16, Issue 07, 077003, (July 2011) https://doi.org/10.1117/12.10.1117/1.3597624

KEYWORDS: Gold, Scattering, Sensors, Absorption, Nanoparticles, Spectroscopy, Tissues, Light scattering, Particles, Water

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Proceedings Article | 18 February 2011 Paper

Dynamics of laser induced thermoelastic expansion of native and coagulated ex vivo soft tissue samples and their optical and thermo-mechanical properties

Behrouz Soroushian, William Whelan, Michael Kolios

Proceedings Volume 7899, 78990Z (2011) https://doi.org/10.1117/12.876011

KEYWORDS: Tissue optics, Kidney, Liver, Tissues, Soft tissue optics, Natural surfaces, Signal attenuation, Thermography, Laser tissue interaction, Interferometry

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Proceedings Article | 16 February 2011 Paper

Spatially-resolved probing of biological phantoms by point-radiance spectroscopy

Serge Grabtchak, Tyler Palmer, William Whelan

Proceedings Volume 7894, 78940A (2011) https://doi.org/10.1117/12.874042

KEYWORDS: Gold, Sensors, Scattering, Chromophores, Spectroscopy, Light scattering, Tissues, Water, Absorption, Nanoparticles

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SPIE Journal Paper | 1 November 2010 Open Access

Study of laser-induced thermoelastic deformation of native and coagulated ex-vivo bovine liver tissues for estimating their optical and thermomechanical properties

Behrouz Soroushian, William Whelan, Michael Kolios

JBO, Vol. 15, Issue 06, 065002, (November 2010) https://doi.org/10.1117/12.10.1117/1.3517455

KEYWORDS: Tissues, Liver, Natural surfaces, Tissue optics, Signal attenuation, Thermography, Pulsed laser operation, Numerical analysis, Soft tissue optics, Interferometry

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SPIE Journal Paper | 1 November 2010 Open Access

Assessment of thermal coagulation in ex-vivo tissues using Raman spectroscopy

Matthew Rodrigues, Robert Weersink, William Whelan

JBO, Vol. 15, Issue 06, 068001, (November 2010) https://doi.org/10.1117/12.10.1117/1.3512231

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Proceedings Article | 24 February 2010 Paper

Optoacoustic imaging of an animal model of prostate cancer

Michelle Patterson, Michel Arsenault, Chris Riley, Michael Kolios, William Whelan

Proceedings Volume 7564, 75641B (2010) https://doi.org/10.1117/12.842873

KEYWORDS: Prostate cancer, Tissues, Prostate, Animal model studies, Tumor growth modeling, Cancer, Imaging systems, Acoustics, Signal generators, Signal detection

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Proceedings Article | 24 February 2010 Paper

Dynamics of thermoelastic expansion for native and coagulated ex vivo bovine liver tissues

Behrouz Soroushian, William Whelan, Michael Kolios

Proceedings Volume 7564, 75641N (2010) https://doi.org/10.1117/12.843042

KEYWORDS: Liver, Tissues, Tissue optics, Signal attenuation, Natural surfaces, Pulsed laser operation, Thermography, Laser energy, Physics, Ultrasonography

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Proceedings Article | 25 February 2009 Paper

Assessment of opto-mechanical behavior of biological samples by interferometry

Behrouz Soroushian, William Whelan, Michael Kolios

Proceedings Volume 7177, 71771X (2009) https://doi.org/10.1117/12.809094

KEYWORDS: Tissue optics, Tissues, Interferometry, Optical parametric oscillators, Signal attenuation, Absorption, Pulsed laser operation, Ultrasonography, Scattering, Beam splitters

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Proceedings Article | 25 February 2009 Paper

Optoacoustic detection of thermal lesions

Michel Arsenault, Michael Kolios, William Whelan

Proceedings Volume 7177, 71771V (2009) https://doi.org/10.1117/12.810913

KEYWORDS: Tissues, Liver, Natural surfaces, Tissue optics, Thermography, Imaging systems, Absorption, Ultrasonography, Physics, Acoustics

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Proceedings Article | 11 March 2008 Paper

Photoacoustic detection of protein coagulation in albumen-based phantoms

Robin Castelino, William Whelan, Michael Kolios

Proceedings Volume 6856, 685626 (2008) https://doi.org/10.1117/12.764305

KEYWORDS: Tissue optics, Photoacoustic spectroscopy, Signal detection, Absorption, Tissues, Ultrasonography, Proteins, Optical parametric oscillators, Acquisition tracking and pointing, Soft tissue optics

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SPIE Journal Paper | 1 November 2007 Open Access

Determination of the optical properties of turbid media using relative interstitial radiance measurements: Monte Carlo study, experimental validation, and sensitivity analysis

Lee Chin, Arthur Worthington, William Whelan, I. Alex Vitkin

JBO, Vol. 12, Issue 06, 064027, (November 2007) https://doi.org/10.1117/12.10.1117/1.2821406

KEYWORDS: Optical properties, Sensors, Scattering, Absorption, Monte Carlo methods, Tissues, Signal attenuation, Diffusion, Photons, Error analysis

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Proceedings Article | 8 March 2006 Paper

Examination of contrast mechanisms in optoacoustic imaging of thermal lesions

Christian Richter, Gloria Spirou, Alexander Oraevsky, William Whelan, Michael Kolios

Proceedings Volume 6086, 60861K (2006) https://doi.org/10.1117/12.650692

KEYWORDS: Absorption, Liver, Tissue optics, Tissues, Scattering, Optical properties, Signal detection, Acoustics, Transducers, Laser tissue interaction

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Optoacoustic Imaging is based on the thermal expansion of tissue caused by a temperature rise due to absorption of short laser pulses. At constant laser fluence, optoacoustic image contrast is proportional to differences in optical absorption and the thermoacoustic efficiency, expressed by the Grueuneisen parameter, Γ. Γ is proportional to the thermal expansion coefficient, the sound velocity squared and the inverse heat capacity at constant pressure. In thermal therapies, these parameters may be modified in the treated area. In this work experiments were performed to examine the influence of these parameters on image contrast. A Laser Optoacoustic Imaging System (LOIS, Fairway Medical Technologies, Houston, Texas) was used to image tissue phantoms comprised of cylindrical Polyvinyl Chloride Plastisol (PVCP) optical absorbing targets imbedded in either gelatin or PVCP as the background medium. Varying concentrations of Black Plastic Color (BPC) and titanium dioxide (TiO₂) were added to targets and background to yield desired tissue relevant optical absorption and effective scattering coefficients, respectively. In thermal therapy experiments, ex-vivo bovine liver was heated with laser fibres (805nm laser at 5 W for 600s) to create regions of tissue coagulation. Lesions formed in the liver tissue were visible using the LOIS system with reasonable correspondence to the actual region of tissue coagulation. In the phantom experiments, contrast could be seen with low optical absorbing targets (μ_a of 0.50cm^-1 down to 0.13cm-1) embedded in a gelatin background (see manuscript for formula). Therefore, the data suggest that small objects (< 5mm) with low absorption coefficients (in the range < 1cm^-1) can be imaged using LOIS. PVCP-targets in gelatin were visible, even with the same optical properties as the gelatin, but different Γ. The enhanced contrast may also be caused by differences in the mechanical properties between the target and the surrounding medium. PVCP-targets imbedded in PVCP produced poorer image contrast than PVCP-targets in gelatin with comparable optical properties. The preliminary investigation in tissue equivalent phantoms indicates that in addition to tissue optical properties, differences in mechanical properties between heated and unheated tissues may be responsible for image contrast. Furthermore, thermal lesions in liver tissue, ex-vivo, can be visualized using an optoacoustic system.

Proceedings Article | 12 July 2004 Paper

Development and testing of an optoacoustic imaging system for monitoring and guiding prostate cancer therapies

Gloria Spirou, I. Alex Vitkin, B. Wilson, William Whelan, Paul Henrichs, Ketan Mehta, Tom Miller, Andrew Yee, James Meador, Alexander Oraevsky

Proceedings Volume 5320, (2004) https://doi.org/10.1117/12.535360

KEYWORDS: Tissue optics, Absorption, Transducers, Tissues, Optical properties, Prostate, Therapeutics, Photodynamic therapy, Acoustics, Imaging systems

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Proceedings Article | 12 July 2004 Paper

Three-dimensional photothermoacoustic depth-profilometric imaging by use of a linear frequency sweep lock-in heterodyne method

Ying Fan, Andreas Mandelis, Gloria Spirou, I. Alex Vitkin, William Whelan

Proceedings Volume 5320, (2004) https://doi.org/10.1117/12.537856

KEYWORDS: Acoustics, Solids, Absorption, Biomedical optics, Tissue optics, Transducers, Modulation, Imaging systems, Scattering, Interfaces

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Proceedings Article | 27 June 2002 Paper

Evaluation of a fuzzy logic controller for laser thermal therapy

Vanessa Choy, Alireza Sadeghian, Michael Sherar, William Whelan

Proceedings Volume 4617, (2002) https://doi.org/10.1117/12.472510

KEYWORDS: Tissues, Temperature metrology, Laser therapeutics, Fuzzy logic, Blood, Tissue optics, Device simulation, Optical properties, Liver, Thermography

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Proceedings Article | 6 June 2002 Paper

Treatment planning platform for photodynamic therapy: architecture, function, and validation

Brian Wilson, William Whelan, Sean Davidson, Robert Weersink, Michael Sherar

Proceedings Volume 4612, (2002) https://doi.org/10.1117/12.469335

KEYWORDS: Photodynamic therapy, Optical fibers, Tissue optics, Tissues, Prostate, Optical properties, Finite element methods, Light, Prostate cancer, Tumors

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