Dr. Wolfgang Beyer Profile

Dr. Wolfgang Beyer

at Ludwig-Maximilians-Univ München

SPIE Involvement:

Author

Publications (24)

Proceedings Article | 29 April 2017 Paper

Photodynamic diagnosis and related optical techniques for the management of malignant glioma

R. Sroka, H. Stepp, W. Beyer, N. Markwardt, A. Rühm

Proceedings Volume 10340, 1034014 (2017) https://doi.org/10.1117/12.2270006

KEYWORDS: Tumors, Tissues, Phototherapy, Tissue optics, Luminescence, Reliability, Integrated optics, Safety

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Proceedings Article | 24 March 2014 Paper

5-ALA based photodynamic management of glioblastoma

Adrian Rühm, Herbert Stepp, Wolfgang Beyer, Georg Hennig, Thomas Pongratz, Ronald Sroka, Oliver Schnell, Jörg-Christian Tonn, Friedrich-Wilhelm Kreth

Proceedings Volume 8928, 89280E (2014) https://doi.org/10.1117/12.2040268

KEYWORDS: Luminescence, Optical fibers, Tumors, Photodynamic therapy, Diffusers, Spectroscopy, Biopsy, Oxygen, Fluorescence spectroscopy, Absorption

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Proceedings Article | 4 March 2014 Paper

Investigation on the smoke development during Laparoscopic surgery

Ronald Sroka, Sebastian Fiedler, Thomas Pongratz, Wolfgang Beyer, Georg Hennig, Adrian Rühm, Wael Khoder

Proceedings Volume 8926, 89261D (2014) https://doi.org/10.1117/12.2037852

KEYWORDS: Tissues, Laparoscopy, Laser ablation, Surgery, Light scattering, Laser therapeutics, Laser tissue interaction, Tissue optics, Autoregressive models, Glasses

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Proceedings Article | 18 February 2012 Paper

Fluorescence guidance during stereotactic biopsy

Herbert Stepp, Wolfgang Beyer, David Brucker, Andre Ehrhardt, Stefan Fischer, Werner Goebel, Marcus Goetz, Bettina Guenther, Georg Hennig, Jochen Herms, Klaus-Martin Irion, Ann Johansson, Yvonne Kienast, Gesa Kniebuehler, Pan Li, Adrian Ruehm, Sabine Sandner

Proceedings Volume 8207, 82074H (2012) https://doi.org/10.1117/12.915751

KEYWORDS: Luminescence, Tumors, Tissues, Brain, Tissue optics, Biopsy, Blood vessels, Fluorescence spectroscopy, Capillaries, Signal detection

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Proceedings Article | 6 April 2011 Paper

Fluorescence and reflectance spectroscopy for protoporphyrin IX quantification in tissue-like media

Gesa Palte, Ann Johansson, Georg Hennig, Wolfgang Beyer, Herbert Stepp

Proceedings Volume 7883, 788340 (2011) https://doi.org/10.1117/12.879768

KEYWORDS: Luminescence, Tissue optics, Absorption, Scattering, Brain, Tissues, Reflectivity, Photodynamic therapy, Fluorescence spectroscopy, Optical properties

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Proceedings Article | 17 May 2010 Paper

Protoporphyrin IX for photodynamic therapy of brain tumours

A. Johansson, F. Kreth, A. Ardeshiri, W. Stummer, O. Schnell, J. Herms, G. Palte, W. Beyer, H. Stepp

Proceedings Volume 7715, 77151M (2010) https://doi.org/10.1117/12.854335

KEYWORDS: Tissues, Photodynamic therapy, Brain, Luminescence, Magnetic resonance imaging, Oxygen, Fluorescence spectroscopy, Surgery, Biopsy, Semiconductor lasers

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Proceedings Article | 13 July 2009 Paper

Photodynamic management of bladder cancer

A. Johansson, H. Stepp, W. Beyer, T. Pongratz, R. Sroka, M. Bader, M. Kriegmair, D. Zaak, R. Waidelich, A. Karl, A. Hofstetter, C. Stief, R. Baumgartner

Proceedings Volume 7380, 73801S (2009) https://doi.org/10.1117/12.828315

KEYWORDS: Bladder, Photodynamic therapy, Luminescence, Cystoscopy, Bladder cancer, Tissue optics, Light sources, Backscatter, Absorption, Light

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Proceedings Article | 13 July 2009 Paper

ALA-mediated fluorescence-guided resection (FGR) and PDT of glioma

Ann Johansson, Herbert Stepp, Tobias Beck, Wolfgang Beyer, Thomas Pongratz, Ronald Sroka, Thomas Meinel, Walter Stummer, Friedrich-Wilhelm Kreth, Jörg-Christian Tonn, Reinhold Baumgartner

Proceedings Volume 7380, 73801D (2009) https://doi.org/10.1117/12.822962

KEYWORDS: Photodynamic therapy, Luminescence, Tissues, Tissue optics, Brain, Semiconductor lasers, Spectroscopy, Silver, Light sources, Magnetic resonance imaging

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A summary of clinical trials employing photodynamic diagnosis (PDD) and photodynamic therapy (PDT) for the diagnosis and treatment of brain malignancies is presented. Intra-cavity PDT has been performed within the surgical cavity following FGR, employing oral administration of 5-aminolevulinic acid (5-ALA), either targeting fluorescing tissue regions that were not removed during FGR due to safety reasons (referred to as focal PDT, n=20) or illuminating the entire resection cavity (referred to as integral PDT, n=9). Both approaches proved technically feasible and safe. Spectroscopic measurements performed pre-, during and post-PDT revealed Protoporphyrin IX (PpIX)-photobleaching of more than 95% after the delivery of 200 J/cm². This light dose did not induce any side effects. Furthermore, interstitial PDT (iPDT) has been employed within one feasibility trial (n=10) and one Phase I/II trial (n=15). Here, three to six cylindrical light diffusors (20-30 mm length, 200 mW/cm, 720 J/cm) were positioned within the target tissue under stereotactic guidance. Pre-treatment planning was performed with the intent to target the entire tumour volume with a sufficient light dose while also minimising the risk of any light-induced temperature increase. For the feasibility trial patients with small, recurrent gliomas were included, resulting in a median survival of 15 months as well as some unexpected longterm survivals (up to 5 years). The Phase I/II trial employed the same clinical procedures. Here, the 12-month survival was 35% and the median progression-free survival was 6 months. In summary, stereotactic iPDT in combination with treatment-planning could be shown to be a safe and feasible treatment modality. These trials are presently being extended to also include on-line monitoring of PpIX fluorescence and photobleaching kinetics. Preliminary data has revealed dramatically different PpIX levels and photobleaching kinetics. Such data could possibly be employed for realtime treatment monitoring and as an early prognostic marker for the PDT response.

Proceedings Article | 23 March 2007 Paper

Ex-vivo investigations on endoluminal vein treatment procedures

R. Sroka, C. Burgmeier, Oliver Meissner, Katrin Hunger, Gregor Barbaryka, W. Beyer, T. Beck, B. Steckmeier, C. Schmedt

Proceedings Volume 6424, 64240M (2007) https://doi.org/10.1117/12.700213

KEYWORDS: Veins, Tissues, Laser therapeutics, Optical coherence tomography, Blood, Absorption, Laser energy, Thermal modeling, Systems modeling, Fiber lasers

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Proceedings Article | 6 March 2006 Paper

Measurement of fluorophore concentration in scattering media by one single optical fiber

Herbert Stepp, Tobias Beck, Wolfgang Beyer, Christian Pfaller, Ronald Sroka, Reinhold Baumgartner

Proceedings Volume 6139, 61390S (2006) https://doi.org/10.1117/12.646144

KEYWORDS: Optical fibers, Tissue optics, Absorption, Photodynamic therapy, Liquids, Luminescence, Scattering, Monte Carlo methods, Scattering media, Light scattering

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Proceedings Article | 25 April 2005 Paper

Fluorescence-guided resections and photodynamic therapy for malignant gliomas using 5-aminolevulinic acid

Herbert Stepp, Tobias Beck, Wolfgang Beyer, Thomas Pongratz, Ronald Sroka, Reinhold Baumgartner, Walter Stummer, Bernhard Olzowy, Jan Mehrkens, Joerg Tonn, Hans Reulen

Proceedings Volume 5686, (2005) https://doi.org/10.1117/12.591526

KEYWORDS: Tumors, Luminescence, Photodynamic therapy, Tissues, Magnetic resonance imaging, Brain, Tissue optics, Optical fibers, Surgery, Fluorescence spectroscopy

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Proceedings Article | 25 April 2005 Paper

Integral photodynamic therapy of bladder cancer using 5-ALA and white light

Reinhold Baumgartner, Raphaela Waidelich, Wolfgang Beyer, Herbert Stepp, Ruth Knuechel-Clarke, Alfons Hofstetter

Proceedings Volume 5686, (2005) https://doi.org/10.1117/12.609197

KEYWORDS: Bladder, Photodynamic therapy, Bladder cancer, Tumors, Tissue optics, Light sources, Absorption, Lamps, Xenon, Light scattering

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Proceedings Article | 15 October 2003 Paper

Clinical determination of tissue optical properties in vivo by spatially resolved reflectance measurements

Tobias Beck, Wolfgang Beyer, Thomas Pongratz, Walter Stummer, Raphaela Waidelich, Herbert Stepp, Simon Wagner, Reinhold Baumgartner

Proceedings Volume 5138, (2003) https://doi.org/10.1117/12.508664

KEYWORDS: Tissue optics, Tissues, In vivo imaging, Bladder, Diffuse reflectance spectroscopy, Brain, Reflectivity, Monte Carlo methods, Optical properties, Tumors

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Proceedings Article | 29 December 1998 Paper

Dosimetric analysis for low-level laser therapy (LLLT) of the human inner ear at 593 nm and 633 nm

Wolfgang Beyer, Reinhold Baumgartner, Stefan Tauber

Proceedings Volume 3569, (1998) https://doi.org/10.1117/12.334384

KEYWORDS: Ear, Acoustics, Microlens, Laser therapeutics, Monte Carlo methods, Helium neon lasers, Refraction, Bone, Sensors, Backscatter

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Proceedings Article | 19 May 1998 Paper

New balloon catheter system used for PDT in the human urinary bladder: accuracy of light distribution

Rolf Eichenauer, Gereon Huettmann, Stephan Woermer, Norbert Koop, Wolfgang Beyer, Dieter Jocham

Proceedings Volume 3247, (1998) https://doi.org/10.1117/12.308141

KEYWORDS: Bladder, Photodynamic therapy, Sensors, Blood, Optical testing, Ultrasonography, Scattering, In vitro testing, Light scattering, Phototherapy

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Proceedings Article | 27 December 1995 Paper

Fluorescence imaging and spectroscopy of ALA-induced protoporphyrin IX preferentially accumulated in tumor tissue

Herbert Stepp, Reinhold Baumgartner, Wolfgang Beyer, Ruth Knuechel, T. Koerner, M. Kriegmair, Kai Rick, Pia Steinbach, Alfons Hofstetter

Proceedings Volume 2627, (1995) https://doi.org/10.1117/12.228884

KEYWORDS: Luminescence, Tissue optics, Absorption, Tissues, Image processing, Plasma, Blood, Imaging spectroscopy, Tumors, Skin

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Proceedings Article | 12 April 1995 Paper

Pharmacokinetics of endogenous porphyrins induced by 5-aminolevulinic acid as observed by means of laser-induced fluorescence from several organs of tumor-bearing mice

Ronald Sroka, Reinhold Baumgartner, Wolfgang Beyer, Liebwin Gossner, T. Sassy, Susanne Stocker

Proceedings Volume 2387, (1995) https://doi.org/10.1117/12.206833

KEYWORDS: Luminescence, Tissues, Photodynamic therapy, Liver, Colon, Kidney, Mathematical modeling, Skin, Tumors, Bladder

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Proceedings Article | 4 January 1995 Paper

Bladder tissue diagnostics utilizing Protoporphyrin IX fluorescence detection

Herbert Stepp, Reinhold Baumgartner, Wolfgang Beyer, Ruth Knuechel, Kai Rick, Pia Steinbach, M. Kriegmair

Proceedings Volume 2324, (1995) https://doi.org/10.1117/12.198739

KEYWORDS: Luminescence, Tumors, Tissues, Tissue optics, Cystoscopy, Bladder, Absorption, Scattering, Blood, Monte Carlo methods

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Proceedings Article | 1 March 1994 Paper

Light dosimetry for photodynamic therapy of superficial tumors in the bladder

Wolfgang Beyer, T. Pongratz, Alfons Hofstetter, Dieter Jocham, Eberhard Unsoeld

Proceedings Volume 2078, (1994) https://doi.org/10.1117/12.168714

KEYWORDS: Bladder, Sensors, Photodynamic therapy, Reflectivity, Signal detection, Tumors, Tissues, Calibration, Tissue optics, Light scattering

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Proceedings Article | 1 March 1994 Paper

Computer modeling of light distributions for diverse photodynamic therapy applicators

Dagmar Kobe, Stefan Spaniol, Wolfgang Beyer, Wolfgang Ertmer

Proceedings Volume 2078, (1994) https://doi.org/10.1117/12.168708

KEYWORDS: Tissue optics, Monte Carlo methods, Tissues, Scattering, 3D modeling, Natural surfaces, Photons, Photodynamic therapy, Absorption, Reflection

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Proceedings Article | 1 August 1992 Paper

Fiber optic probes for tissue illumination in photodynamic diagnosis and therapy

Reinhold Baumgartner, Wolfgang Beyer, G. Friedsam, Dieter Jocham, Axel Noack, Ronald Sroka, Herbert Stepp, Eberhard Unsoeld

Proceedings Volume 1649, (1992) https://doi.org/10.1117/12.60226

KEYWORDS: Endoscopes, Photodynamic therapy, Fiber optics, Tissue optics, Microlens, Luminescence, Optical fibers, Lenses, Lung, Tumors

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Proceedings Article | 1 July 1990 Paper

Light monitoring by isotropic and by integrated fiber detectors

Ronald Sroka, Reinhold Baumgartner, Wolfgang Beyer, Christian Ell, G. Gebhardt, Armin Heinze, Dieter Jocham, Eberhard Unsoeld

Proceedings Volume 1201, (1990) https://doi.org/10.1117/12.17552

KEYWORDS: Sensors, Optical spheres, Photons, Fiber lasers, Optical fibers, Backscatter, Photodiodes, Signal detection, Medicine, Laser tissue interaction

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Proceedings Article | 1 July 1990 Paper

Modified fiber tips for light application in hollow organs

Armin Heinze, Wolfgang Beyer, M. Krug, K. Schaarschmidt, Ronald Sroka, Herbert Stepp, Eberhard Unsoeld, G. Willital

Proceedings Volume 1201, (1990) https://doi.org/10.1117/12.17550

KEYWORDS: Light scattering, Scattering, Photodynamic therapy, Optical fibers, Medicine, Esophagus, Mirrors, Refraction, Bladder, Tissues

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Proceedings Article | 1 July 1990 Paper

Uniform light distribution in hollow organs by means of backscattering layers

Wolfgang Beyer, Reinhold Baumgartner, Christian Ell, Armin Heinze, Dieter Jocham, Ronald Sroka, Herbert Stepp, Eberhard Unsoeld

Proceedings Volume 1201, (1990) https://doi.org/10.1117/12.17549

KEYWORDS: Backscatter, Homogenization, Spherical lenses, Tissue optics, Scattering, Tumors, Tissues, Bladder, Optical fibers, Medicine

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Showing 5 of 24 publications

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