Dr. Xin Zhou Profile

Dr. Xin Zhou

at Univ. of British Columbia

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Author

Publications (11)

Proceedings Article | 13 March 2024 Presentation

Multi-modal comparison of polarization and coherence-based skin measurement techniques: preliminary results

Daniel Louie, Sina Maloufi, Mitra Mirsalehi, Xin Zhou, Shuo Tang, Tim Lee

Proceedings Volume PC12816, PC1281603 (2024) https://doi.org/10.1117/12.3000555

KEYWORDS: Polarization, Skin, Physical coherence, Tissues, Speckle, Optical coherence tomography, Surface roughness, Optical coherence, Depolarization, Color

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Proceedings Article | 13 March 2024 Presentation + Paper

Analysis of attenuation coefficient and polarization-based contrasts in skin using polarization-sensitive optical coherence tomography

Sina Maloufi, Xin Zhou, Daniel Louie, Tim Lee, Shuo Tang, Mitra Mirsalehi

Proceedings Volume 12816, 128160D (2024) https://doi.org/10.1117/12.3001991

KEYWORDS: Optical coherence tomography, Skin, Attenuation, Absorption, Signal attenuation, Scattering, Tissues, Polarization, In vivo imaging, Image segmentation

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Proceedings Article | 17 March 2023 Presentation

Characterizing skin properties non-invasively by polarization-sensitive optical coherence tomography

Xin Zhou, Daniel Louie, Sina Maloufi, Yuheng Wang, Tim Lee, Shuo Tang

Proceedings Volume PC12352, PC123520S (2023) https://doi.org/10.1117/12.2649446

KEYWORDS: Skin, Optical coherence tomography, Tissues, Surface roughness, Polarization, Image segmentation, Collagen, Birefringence, Tissue optics, Statistical analysis

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Proceedings Article | 8 March 2023 Presentation + Paper

Epidermal-dermal segmentation and polarization feature analysis using advanced Jones matrix optical coherence tomography

Sina Maloufi, Xin Zhou, Shuo Tang, Daniel Louie, Tim Lee, Mitra Mirsalehi

Proceedings Volume 12367, 123670O (2023) https://doi.org/10.1117/12.2653006

KEYWORDS: Skin, Optical coherence tomography, Birefringence, Polarization, Image segmentation, Depolarization, Matrices, Collagen, Tissues, Diseases and disorders

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Proceedings Article | 7 March 2022 Poster + Paper

Skin layer structure characterization via multi-contrast polarization-sensitive optical coherence tomography

Sina Maloufi, Xin Zhou, Shuo Tang

Proceedings Volume 11948, 119480H (2022) https://doi.org/10.1117/12.2613256

KEYWORDS: Polarization, Skin, Optical coherence tomography, Birefringence, Skin cancer, Tissues, Phase measurement, Melanoma, Light scattering, Visualization

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Skin cancer is one of the most prevalent types of cancer in the world, with a steadily increasing incidence rate and associated health burden [1, 2]. While it is generally treatable when detected, survival rates decrease dramatically as the disease progresses – highlighting the importance of early detection [3]. Unfortunately, the current gold standard in diagnosing skin cancers involves taking biopsies followed by histopathology, which is invasive and time consuming. Some studies have shown that the majority of biopsies ordered by primary care providers were found to be benign, meaning that biopsies are often performed when there is no cancer present [4]. Given this, there is a great interest in developing noninvasive diagnostic tools for skin imaging. Optical coherence tomography (OCT) is an imaging modality that is particularly well suited for this area, owing to its ability to provide high-resolution (3-15 μm) volumetric data at a penetration depth of up to 1.5 mm [5]. In a manner analogous to ultrasound, it provides cross-sectional images which can be comparable to histology slides [6]. However, conventional intensity-based OCT only provides structural information with no functional contrast, and as a result it has encountered difficulty in diagnosing specific cancers such as melanoma [7]. Polarization sensitive optical coherence tomography (PS-OCT) is a functional extension of OCT which can characterize polarization properties such as the birefringence of tissue samples – birefringence specifically occurs in fibrous structures such as collagen [8]. Several groups have investigated birefringence in skin tissue using PS-OCT, but little work has been done with the more recently defined degree of polarization uniformity (DOPU) contrast. The functional contrast provided by DOPU PS-OCT imaging can provide localized, depth-resolved information on the polarization scrambling properties of samples. A specific example of this is in ophthalmic imaging, where DOPU contrast in PS-OCT imaging demonstrated the ability to segment the retinal pigment epithelium – a layer otherwise hard to differentiate in intensity-based OCT imaging [9]. To our knowledge, very few if any groups have investigated PS-OCT imaging with DOPU contrast in understanding the layered-structure of skin. We have recently investigated the DOPU in skin tissue phantoms and reported that DOPU is sensitive to surface roughness – an important factor in differentiating skin cancers from benign lesions. Our group has a previously reported PS-OCT system that can simultaneously acquire reflectance, phase retardation (birefringence), and DOPU images that we aim to use in this study to expand on our previous work and further investigate polarization properties in skin in vivo [10].

Proceedings Article | 19 February 2020 Paper

Polarization sensitive optical coherence tomography for assessing skin roughness

Xin Zhou, Daniel Louie, Sina Maloufi, Qihao Liu, Lioudmila Tchvialeva, Tim Lee, Shuo Tang, Lin Huang

Proceedings Volume 11211, 112110A (2020) https://doi.org/10.1117/12.2547139

KEYWORDS: Skin, Polarization, Optical coherence tomography, Melanoma, Natural surfaces, Skin cancer, Surface roughness, Tissues, Scattering, Absorption

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SPIE Journal Paper | 14 March 2019 Open Access

Slope-based segmentation of articular cartilage using polarization-sensitive optical coherence tomography phase retardation image

Xin Zhou, Myeong Jin Ju, Lin Huang, Shuo Tang

JBO, Vol. 24, Issue 03, 036006, (March 2019) https://doi.org/10.1117/12.10.1117/1.JBO.24.3.036006

KEYWORDS: Image segmentation, Cartilage, Birefringence, Tissues, Collagen, Natural surfaces, Optical coherence tomography, Second-harmonic generation, Phase measurement, Tissue optics

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Proceedings Article | 26 February 2019 Presentation + Paper

Multimodal imaging with optical coherence tomography and multiphoton microscopy of human hip joint osteoarthritis

Xin Zhou, Hanadi Alousaimi, Ruochen Wen, Lin Huang, Rizhi Wang, Shuo Tang

Proceedings Volume 10868, 1086809 (2019) https://doi.org/10.1117/12.2511012

KEYWORDS: Cartilage, Collagen, Natural surfaces, Tissues, Optical coherence tomography, Birefringence, Bone, Multimodal imaging, Photography, Multiphoton microscopy

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SPIE Journal Paper | 21 December 2018 Open Access

Optimization of frequency-doubled Er-doped fiber laser for miniature multiphoton endoscopy

Lin Huang, Xin Zhou, Shuo Tang

JBO, Vol. 23, Issue 12, 126503, (December 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.12.126503

KEYWORDS: Single mode fibers, Endoscopy, Fiber lasers, Picosecond phenomena, Imaging systems, Tissues, Oscillators, Pulsed laser operation, Dispersion, Femtosecond phenomena

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Proceedings Article | 14 February 2018 Paper

Investigation in clinical potential of polarization sensitive optical coherence tomography in laryngeal tumor model study

Yeh-Chan Ahn, Sung Won Kim, Shuo Tang, Xin Zhou, Chulho Oak

Proceedings Volume 10483, 1048339 (2018) https://doi.org/10.1117/12.2292021

KEYWORDS: Tissues, Tumors, Birefringence, Collagen, Optical coherence tomography, Cancer, Phase measurement, Polarization, Optical fibers, Tissue optics

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Proceedings Article | 17 February 2017 Presentation + Paper

Correlation between polarization sensitive optical coherence tomography and SHG microscopy in articular cartilage

Xin Zhou, Myeong Jin Ju, Lin Huang, Shuo Tang

Proceedings Volume 10053, 1005319 (2017) https://doi.org/10.1117/12.2254929

KEYWORDS: Cartilage, Collagen, Second-harmonic generation, Tissues, Optical coherence tomography, Microscopy, Optical fibers, Natural surfaces, Image segmentation, Birefringence

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Showing 5 of 11 publications

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