Prof. Yan Yu Profile

Prof. Yan Yu

at Jefferson

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Proceedings Article | 8 January 2008 Paper

Sono-contrast spectroscopy for breast cancer detection

Yan Yu, Lydia Liao

Proceedings Volume 6826, 68260F (2008) https://doi.org/10.1117/12.779460

KEYWORDS: Ultrasonography, Tumors, Tissues, Breast, Spectroscopy, Tissue optics, Breast cancer, Diagnostics, Near infrared, Blood circulation

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In a preclinical study, we demonstrated that blood flow and tissue oxygenation could be manipulated by focused ultrasound; the effects of such manipulation were interrogated via optical spectroscopy at wavelengths where oxy- and deoxy-hemoglobin display different extinction properties. We have designed a clinical breast scanner based on these noninvasive techniques. In addition to the focused ultrasound field intersecting with the volume of optical illumination and points of spectral collection, a diagnostic quality breast imaging probe is incorporated into the scanhead to achieve image guidance. Experimental confirmation of the system performance of the focused ultrasound field properties, diagnostic imaging capabilities and NIR spectroscopy subsystem has been carried out to demonstrate readiness for a clinical study involving 200 patients who are scheduled to undergo ultrasound-guided biopsy to rule out breast cancers.

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