Mr. Yang Lou Profile

Yang Lou

Student at Washington Univ in St Louis

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Author

Publications (11)

Proceedings Article | 11 April 2018 Paper

Full-view 3D imaging system for functional and anatomical screening of the breast

Alexander Oraevsky, Richard Su, Ha Nguyen, James Moore, Yang Lou, Sayantan Bhadra, Luca Forte, Mark Anastasio, Wei Yang

Proceedings Volume 10494, 104942Y (2018) https://doi.org/10.1117/12.2318802

KEYWORDS: Breast, Optoacoustics, Imaging systems, Tumors, Transducers, Ultrasonography, Ultrasonics, 3D image processing, Diagnostics, Tomography

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Laser Optoacoustic Ultrasonic Imaging System Assembly (LOUISA-3D) was developed in response to demand of diagnostic radiologists for an advanced screening system for the breast to improve on low sensitivity of x-ray based modalities of mammography and tomosynthesis in the dense and heterogeneous breast and low specificity magnetic resonance imaging. It is our working hypothesis that co-registration of quantitatively accurate functional images of the breast vasculature and microvasculature, and anatomical images of breast morphological structures will provide a clinically viable solution for the breast cancer care. Functional imaging is LOUISA-3D is enabled by the full view 3D optoacoustic images acquired at two rapidly toggling laser wavelengths in the near-infrared spectral range. 3D images of the breast anatomical background is enabled in LOUISA-3D by a sequence of B-mode ultrasound slices acquired with a transducer array rotating around the breast. This creates the possibility to visualize distributions of the total hemoglobin and blood oxygen saturation within specific morphological structures such as tumor angiogenesis microvasculature and larger vasculature in proximity of the tumor. The system has four major components: (i) a pulsed dual wavelength laser with fiberoptic light delivery system, (ii) an imaging module with two arc shaped probes (optoacoustic and ultrasonic) placed in a transparent bowl that rotates around the breast, (iii) a multichannel electronic system with analog preamplifiers and digital data acquisition boards, and (iv) computer for the system control, data processing and image reconstruction. The most important advancement of this latest system design compared with previously reported systems is the full breast illumination accomplished for each rotational step of the optoacoustic transducer array using fiberoptic illuminator rotating around the breast independently from rotation of the detector probe. We report here a pilot case studies on one healthy volunteer and on patient with a suspicious small lesion in the breast. LOUISA3D visualized deoxygenated veins and oxygenated arteries of a healthy volunteer, indicative of its capability to visualize hypoxic microvasculature in cancerous tumors. A small lesion detected on optoacoustic image of a patient was not visible on ultrasound, potentially indicating high system sensitivity of the optoacoustic subsystem to small but aggressively growing cancerous lesions with high density angiogenesis microvasculature. The main breast vasculature (0.5-1 mm) was visible at depth of up to 40-mm with 0.3-mm resolution. The results of LOUISA-3D pilot clinical validation demonstrated the system readiness for statistically significant clinical feasibility study.

Proceedings Article | 10 March 2017 Paper

Task-based data-acquisition optimization for sparse image reconstruction systems

Yujia Chen, Yang Lou, Matthew Kupinski, Mark Anastasio

Proceedings Volume 10136, 101360Z (2017) https://doi.org/10.1117/12.2255536

KEYWORDS: Image restoration, Systems modeling, Imaging systems, Magnetic resonance imaging, Reconstruction algorithms, Information operations, Statistical modeling, Compressed sensing, Stochastic processes, Bayesian inference, Signal detection, Data acquisition, Statistical analysis

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Proceedings Article | 9 March 2017 Paper

Estimating posterior image variance with sparsity-based object priors for MRI

Yujia Chen, Yang Lou, Cihat Eldeniz, Hongyu An, Mark Anastasio

Proceedings Volume 10132, 101321J (2017) https://doi.org/10.1117/12.2255555

KEYWORDS: Magnetic resonance imaging, Bayesian inference, Image analysis, Reconstruction algorithms, Image restoration, Probability theory, Medical image reconstruction, Monte Carlo methods, Reliability, Optical imaging, Brain mapping, Imaging systems, Medical imaging, Brain, Image segmentation, Data modeling

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SPIE Journal Paper | 31 January 2017 Open Access

Generation of anatomically realistic numerical phantoms for photoacoustic and ultrasonic breast imaging

Yang Lou, Weimin Zhou, Thomas Matthews, Catherine Appleton, Mark Anastasio

JBO, Vol. 22, Issue 04, 041015, (January 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.4.041015

KEYWORDS: Breast, Skin, Photoacoustic tomography, Tissues, Tissue optics, Acoustics, Breast imaging, Binary data, Magnetic resonance imaging, Ultrasonics

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Proceedings Article | 29 March 2016 Paper

Advanced laser system for 3D optoacoustic tomography of the breast

Marc Klosner, Gary Chan, Chunbai Wu, Donald Heller, Richard Su, Sergey Ermilov, Hans Peter Brecht, Vassili Ivanov, Pratik Talole, Yang Lou, Mark Anastasio, Alexander Oraevsky

Proceedings Volume 9708, 97085B (2016) https://doi.org/10.1117/12.2209398

KEYWORDS: Breast, Laser systems engineering, Absorption, Imaging systems, Pulsed laser operation, Alexandrite lasers, Tissues, Blood, Breast imaging, Optical parametric oscillators

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Proceedings Article | 15 March 2016 Paper

Application of signal detection theory to assess optoacoustic imaging systems

Yang Lou, Alexander Oraevsky, Mark Anastasio

Proceedings Volume 9708, 97083Z (2016) https://doi.org/10.1117/12.2217928

KEYWORDS: Imaging systems, Detection theory, Tissues, Photoacoustic tomography, Breast, Monte Carlo methods, Signal detection, Tomography, Breast cancer, Mammography, Tumors, Signal to noise ratio, Computing systems, Tissue optics, Transducers, Computer simulations

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Proceedings Article | 15 March 2016 Paper

Generation of anatomically realistic numerical phantoms for optoacoustic breast imaging

Yang Lou, Kenji Mitsuhashi, Catherine Appleton, Alexander Oraevsky, Mark Anastasio

Proceedings Volume 9708, 97084O (2016) https://doi.org/10.1117/12.2217609

KEYWORDS: Breast, Image segmentation, Breast imaging, Imaging systems, Photoacoustic tomography, Breast cancer, Computer simulations, Computing systems, Tissues, Tissue optics, Skin, Acoustics, Binary data, Magnetic resonance imaging

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Proceedings Article | 17 March 2015 Paper

Sparsity-driven ideal observer for computed medical imaging systems

Kun Wang, Yang Lou, Matthew Kupinski, Mark Anastasio

Proceedings Volume 9416, 94161C (2015) https://doi.org/10.1117/12.2082316

KEYWORDS: Information operations, Imaging systems, Statistical analysis, Computing systems, Medical imaging, Statistical modeling, Data acquisition, Bayesian inference, Interference (communication), Magnetic resonance imaging

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Proceedings Article | 11 March 2015 Paper

Effect of rotating partial illumination on image reconstruction for optoacoustic breast tomography

Yang Lou, Vyacheslav Nadvoretskiy, Kun Wang, Sergey Emilov, Alexander Oraevsky, Mark Anastasio

Proceedings Volume 9323, 93233L (2015) https://doi.org/10.1117/12.2084909

KEYWORDS: Breast, Transducers, Monte Carlo methods, Image restoration, Absorption, Tomography, Acoustics, Mammography, Imaging systems, Data modeling

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Proceedings Article | 3 March 2014 Paper

Mouse brain imaging using photoacoustic computed tomography

Yang Lou, Jun Xia, Lihong Wang

Proceedings Volume 8943, 894340 (2014) https://doi.org/10.1117/12.2039669

KEYWORDS: Brain, Photoacoustic tomography, Neuroimaging, Brain imaging, Arteries, Acoustics, Transducers, In vivo imaging, Acquisition tracking and pointing, Blood

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Proceedings Article | 3 March 2014 Paper

Investigation of the adjoint-state method for ultrasound computed tomography: a numerical and experimental study

Fatima Anis, Yang Lou, André Conjusteau, Richard Su, Tanmayi Oruganti, Sergey Ermilov, Alexander Oraevsky, Mark Anastasio

Proceedings Volume 8943, 894337 (2014) https://doi.org/10.1117/12.2042636

KEYWORDS: Ultrasonography, Reconstruction algorithms, Computed tomography, Imaging systems, Breast imaging, Biomedical optics, Transducers, CT reconstruction, Image restoration, Tomography

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Showing 5 of 11 publications

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