Atopic dermatitis (AD) is a common inflammatory skin disorder which affects ~20% of children and ~3% adults worldwide. There lacks a direct, non-invasive method of evaluating atopic dermatitis (AD) accurately. Here, the use a multispectral raster-scanning optoacoustic mesoscopy (MS-RSOM) as an objective imaging tool for AD is proposed. MS-RSOM is a novel, non-invasive optoacoustic imaging modality which can provide label-free, high resolution imaging up to 1.5 mm below the skin. It can provide useful information on melanin, oxyhemoglobin (HbO2), deoxyhemoglobin (Hb) and oxygen saturation (sO2) from the skin layers. This preliminary study was conducted on 4 AD patients and 2 healthy volunteers using MS-RSOM system. From the MS-RSOM images, the epidermis thickness and oxygen saturation were computed from the healthy volunteers as well as from the non-lesional and eczema lesional areas of the eczema subjects.
Inflammatory skin disorder, eczema, is usually assessed by subjective disease scoring systems such as SCORAD and EASI. These scoring systems are based on clinical observations and questionnaires and hence it is subjected to inter and intra-assessor variability. Here, for the first time, we used optoacoustic imaging to image the structural and morphological changes of the skin in a non-invasive manner. Through a clinical study, we computed specific metrics such as epidermis thickness, total blood volume, vessel diameter in the dermis, ratio of low and high frequency signals. We trained a linear kernel-based support vector machine model for eczema classification using these metrics. We could achieve an accuracy of 86.6% and high sensitivity and specificity of 96.2% and 82.1% respectively. We also formulated a novel Eczema Vascular and Structural Index (EVSI) to objectively assess the severity of eczema.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.