The fabrication and characterization of a highly sensitive DNA biosensor based on thin-core fiber modal interferometer
(TCFMI) are presented. The TCFMI is made by using a thin-core fiber (TCF) with core diameter of ~3.0 μm and etched
by using Hydrofluoric (HF) acid solution for sensitivity enhancement. A thin layer of polymer (PLL, poly-L-lysine) was
coated on the sensor surface and experimentally demonstrated for the detection of hybridization of deoxyribonucleic acid
(DNA).
We present some novel periodic structures with different internal nanopatterns based on multi-exposure two-beam
interference lithography. Two-dimensional quasi-crystal structures are fabricated with precisely control of exposure
directions and doses as well as the total number of exposures. Experimental fabrication of microstructures are
demonstrated and comparied with numerical simulations of intensity distributions. The size of the fabricated samples is
around 1 square centimeter. The diffraction spectra of the fabricated samples are measured and tested. The experiment
results show such a fabrication technology is very promising for making diverse large-area microstructures with complex
internal nanopatterns.
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