The structural characteristics of bile duct tissue can indirectly reflect the physiological function of the bile duct, so understanding the pathological process of bile duct tissue can improve the prognosis of intrahepatic cholangiocarcinoma. However, the existing technology cannot accurately and quickly determine the stage of the bile duct tissue lesion, which will have a certain impact on the treatment. In this study, normal bile ducts, inflammatory bile ducts, and intrahepatic cholangiocarcinoma were distinguished using label-free multiphoton microscopy (MPM). The experimental results show that high-resolution images can clearly distinguish normal bile duct, inflammatory bile duct and intrahepatic cholangiocarcinoma through cell morphology and tissue structure. Therefore, MPM can be used as an effective optical tool for the diagnosis of intrahepatic cholangiocarcinoma in unstained histological sections. It is expected in the future that MPM can play a greater role in the clinic.
A multichannel all fiber current sensor that can be used to measure currents at different positions simultaneously is presented in the paper. Each sensor head uses single-polarization single-mode devices and loop scheme to realize current measurement. All the sensor heads are connected via a series structure and the measured results are received by only one photo-detector based on the principle of time-division multiplexing. Theory and experiment prove that the sensor is feasible.
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