Dr. Yusung Jin Profile

Dr. Yusung Jin

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 9 September 2019 Presentation

Photoluminescent silicon nanoparticles as a self-reporting nanomedicine (Conference Presentation)

Yusung Jin, Goun Lee, Chan-Gi Pack, Jun Ki Kim, Jinmyoung Joo

Proceedings Volume 11087, 1108703 (2019) https://doi.org/10.1117/12.2530145

KEYWORDS: Silicon, Nanoparticles, Nanomedicine, Tissues, Optical tracking, Luminescence, Molecules, In vivo imaging, Visualization

Read Abstract +

Porous silicon nanoparticles (PSiNPs) have attracted increasing interest for imaging and treatment of diseases due to biocompatibility, large specific capacity for drug loading, non-toxic degradation products, and intrinsic photoluminescence (PL). In particular, the PL lifetime is typically on the order of microseconds, significantly longer than the nanosecond lifetimes exhibited by fluorescent molecules naturally presented in cells and tissues, thus allows discrimination of the silicon nanoparticle from the tissue autofluorescence. Herein, the long-lived PL is employed to monitor the status of drug payload elution, associated with biodegradation of the silicon nanocarriers, and demonstrated as a “self-reporting” system. Dissolution of the silicon matrix in physiological environment triggers drug release, along with decreasing intensity and blue shift of the PL spectra. Furthermore, by tracking the PL lifetime, the drug releasing status and the residual lifespan of the silicon nanocarriers are correspondingly acquired. The PL lifetime is a physically intensive property that can report only the inherent characteristics of the PSiNPs regardless of surrounding noise while the intensity-based reporting is substantially affected by many unwanted factors. We investigate a unique means to inform the lifespan of the PSiNPs as a biodegradable drug nanocarrier in vivo. This study presents a promising potential of the photoluminescent PSiNPs toward advanced drug delivery systems for translational medical platform including theranostics and visualized drug delivery tracking.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years