Noise performance of the high speed image sensor is a bottle neck for its low illumination applications. As the foremost stage circuit, pixel noise is an important portion of high speed image sensor system. This paper has discussed and analyzed the different noise source of the 4T pixel and influence on the image quality of high speed image sensor in detail. We proposed circuit model of pixel with ideal correlated double sampler to simulate the noise source distribution in the pixel and noise reducing methods. Pixel random readout noise can be effectively reduced to 5.44e by optimizing the gate size of the reset transistor.