Dr. Ziver Kardasheva Profile

Dr. Ziver Kardasheva

at A N Kosygin Russian State Univ

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Proceedings Article | 4 March 2019 Paper

Evaluation of metastatic potential of circulating tumor cells using quantitative phase imaging (QPI)

Irina Vasilenko, Vladislav Metelin, Ziver Kardasheva, Andrey Balkanov, Roman Lifenko

Proceedings Volume 10887, 1088724 (2019) https://doi.org/10.1117/12.2510383

KEYWORDS: Tumors, Blood, Cancer, Phase imaging, Oncology, Cell death, Microscopes, Visualization, Molecules, Biological research

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Revealing and characterization of circulating tumor cells (CTCs) is one of the most actively investigated field of oncology. It was established by the past time studies that some of these cells were in condition of apoptosis and so couldn’t initiate formation of a clinically significant metastasis. The novel opportunities associated with development of computer technologies and interferential microscopes facilitate the solution of many medico-biological problems. One of them is a method of determination of CTCs functional condition based on the phase-interferential characteristics of their nuclear structures which reflect cellular metabolic and proliferative activity and are the markers of their malignant transformation.

The analysis was carried out of the morphodensitometric biomarkers of the metastatic activity of circulating tumorous cells including conformational alterations of their nuclear structures. The reference collection of phase images of metastatic cells was created as well as the data of the morphodensitometric parameters of their metabolic activity was received.

A new information was received about heterogeneity of the circulating tumorous cells with different metastatic activity which allows the broadening of fundamental scientific knowledge concerning cancerogenesis, individualization of the observation and treatment of patients, improvement of the quality of treatment, and optimization of its cost.

Proceedings Article | 23 February 2018 Paper

Quantitative phase imaging of platelets in patients with chronic renal failure treated with hemodialysis

Irina Vasilenko, Elizaveta Vlasova, Vladislav Metelin, Ziver Kardasheva

Proceedings Volume 10503, 105031N (2018) https://doi.org/10.1117/12.2291416

KEYWORDS: Blood, Phase imaging, Kidney, Refractive index, Failure analysis, Microscopes, Statistical analysis, Collagen, Clinical research, Medicine

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The development of robust non-invasive laboratory screening methods for early diagnosis on the out-patient basis seems quite relevant for practical medicine. It is known, that platelet is an original biosensor, a detector of early changes in hemostasis condition. The aim of this study was to assess a potential of the quantitative phase imaging (QPI) technique for real time evaluation the influence of low-molecular weight and unfractionated heparin on platelets in patients with the end-stage of chronic renal failure, who were treated with program hemodialysis (PHD).

The main group consisted of 21 patients who were administered a low-molecular weight heparin for hypocoagulation during the procedure of hemodialysis. The control group (15 patients) received unfractionated heparin. Morphodensitometric state of living platelets we evaluated by QPI using computer phase-interference microscope MIM (Moscow, Russia). We analyzed the optical–geometrical parameters and the morphological features of living platelets which reflected the degree of their activation at the beginning of PHD (before administration of heparin), in 15 minutes after it and at the end of the procedure. The results allow us to conclude that the use of low-molecular weight heparin provides better ratio of efficacy/safety and causes a reduction of the platelet activation during the hemodialysis procedure. Practical implementation of QPI for clinical monitoring of platelets makes it possible to obtain important information on hemostasis cell. It opens new opportunities to assess the efficacy of treatment, as well as for early diagnosis of complications for disease.

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