Dr. Cristiano D'Andrea Profile

Dr. Cristiano D'Andrea

at Istituto di Fisica Applicata "Nello Carrara"

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Publications (5)

Proceedings Article | 9 December 2021 Paper

Label-free SERS/machine learning procedures for protein classification

Edoardo Farnesi, Andrea Barucci, Cristiano D'Andrea, Martina Banchelli, Chiara Amicucci, Marella de Angelis, Michael Schmitt, Paolo Matteini

Proceedings Volume 11920, 1192025 (2021) https://doi.org/10.1117/12.2615448

KEYWORDS: Proteins, Principal component analysis, Biological research, Statistical analysis, Data processing, Raman scattering, Photonics, Machine learning, Silver, Medicine

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SPIE Journal Paper | 2 July 2020 Open Access

Hollow core photonic crystal fiber-assisted Raman spectroscopy as a tool for the detection of Alzheimer’s disease biomarkers

Pinkie Eravuchira, Martina Banchelli, Cristiano D'Andrea, Marella De Angelis, Paolo Matteini, Israel Gannot

JBO, Vol. 25, Issue 07, 077001, (July 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.7.077001

KEYWORDS: Raman spectroscopy, Surface enhanced Raman spectroscopy, Photonic crystals, Alzheimer's disease, Proteins, Bioalcohols, Spectroscopy, Nanoparticles, Molecules

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Proceedings Article | 1 April 2020 Presentation

A SERS affinity bioassay based on ion-exchanged glass microrods (Conference Presentation)

Simone Berneschi, Cristiano D'Andrea, Ambra Giannetti, Marella De Angelis, Martina Banchelli, Andrea Barucci, Nadia Giovanna Boetti, Stefano Pelli, Francesco Baldini, Roberto Pini, Davide Janner, Diego Pugliese, Daniel Milanese, Paolo Matteini

Proceedings Volume 11361, 113610V (2020) https://doi.org/10.1117/12.2555817

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The well-known enhancement effect of surface-enhanced Raman spectroscopy (SERS) is associated with the presence of metallic nanostructures at the substrate surface. Different bottom-up and top-down processes have been proposed to impart the substrate with such a nanostructured layer. The former approaches are low cost but may suffer from reusability and stability. The latter strategies are expensive, time consuming and require special equipment that complicate the fabrication process. Here, we present the possibility to obtain stable and reusable SERS substrates by a low-cost silver-sodium ion-exchange process in soda-lime glass microrods. The microrods were obtained by cutting the tip of the ion-exchanged soda-lime fiber, resulting in disks of about few millimeters in length and one hundred microns in diameter. A thermal annealing post-process was applied to trigger the reduction of Ag+ ions into nanoparticles (AgNPs) within the ion-exchanged glass microrods. Afterwards, ion-exchange and thermal treatments were carefully tuned to assure the presence of silver NPs exposed on the surface of the microrods, without using any chemical etching. An AFM analysis confirmed the presence of AgNPs with size of tens of nm on the surface of the fiber probe. A SERS affinity bioassay was developed on the probe with the final aim of detecting microRNA fragments acting as biomarkers of different diseases. Specifically a DNA hybridization assay was built up by anchoring a molecular beacon containing a Raman tag on the Ag surface via thiol chemistry. Initial SERS experiments confirmed the presence of the beacon on the NPs embedded on the microrods surface, as monitored by detecting main spectral bands ascribed to the oligonucleotide chain. Finally, the ability of the platform to interact with the target microRNA sequence was assessed. The analysis was repeated on a number of miRNA sequences differing from the target to evaluate the specificity of the proposed assay.

Proceedings Article | 27 February 2019 Presentation + Paper

Fiber-enhanced Raman spectroscopy as a tool for an early detection of Alzheimer's disease biomarkers

P. Eravuchira, M. Banchelli, C. D'Andrea, M. De Angelis, P. Matteini, I. Gannot

Proceedings Volume 10872, 1087211 (2019) https://doi.org/10.1117/12.2516545

KEYWORDS: Raman spectroscopy, Alzheimer's disease, Spectroscopy, Raman scattering, Photonic crystal fibers, Liquids

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Proceedings Article | 13 February 2018 Paper

Plasmon-enhanced Raman detection of body-fluid components

Paolo Matteini, Martina Banchelli, Marella De Angelis, Cristiano D'Andrea, Roberto Pini

Proceedings Volume 10488, 104880W (2018) https://doi.org/10.1117/12.2295086

KEYWORDS: Raman spectroscopy, Surface enhanced Raman spectroscopy, Molecules, Plasmonics, Nanoparticles, Molecular assembly, Biological research, Biomedical optics

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