Dr. Martial Guillaud Profile

Dr. Martial Guillaud

Scientist at BC Cancer Agency Research Ctr

SPIE Involvement:

Author

Publications (19)

Proceedings Article | 4 April 2022 Poster + Paper

Investigating intra-tumor heterogeneity in non-small cell lung cancer using multiplexed immunohistochemistry and deep learning

Kouther Noureddine, Paul Gallagher, Griffin Thomas, Sylvia Lam, Gavin MacAulay, Anna McGuire, John English, Martial Guillaud, Calum MacAulay

Proceedings Volume 12039, 120391P (2022) https://doi.org/10.1117/12.2624042

KEYWORDS: Image segmentation, Tissues, Multiplexing, Lung cancer, Cancer, Pathology, Tumors, Hyperspectral imaging, Biological research, Oncology

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SPIE Journal Paper | 10 May 2021 Open Access

Assessment of internal refractive index profile of stochastically inhomogeneous nuclear models via analysis of two-dimensional optical scattering patterns

Dizem Arifler, Martial Guillaud

JBO, Vol. 26, Issue 05, 055001, (May 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.5.055001

KEYWORDS: Refractive index, Scattering, Tissue optics, Spherical lenses, Light scattering, Statistical modeling, Finite-difference time-domain method, 3D modeling, Diagnostics, Tissues

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Proceedings Article | 19 July 2019 Paper

Identification of azimuthal light scattering signatures to selectively track changes in subnuclear refractive index profile of epithelial cell models

Dizem Arifler, Martial Guillaud

Proceedings Volume 11073, 110730P (2019) https://doi.org/10.1117/12.2526727

KEYWORDS: Refractive index, Light scattering, Scattering, Finite-difference time-domain method, Tumor growth modeling, Cancer, Tissue optics, Diagnostics, Tissues, Matrices

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SPIE Journal Paper | 19 August 2017 Open Access

Dual-mode endomicroscopy for detection of epithelial dysplasia in the mouth: a descriptive pilot study

Nico Bodenschatz, Catherine Poh, Sylvia Lam, Pierre Lane, Martial Guillaud, Calum MacAulay

JBO, Vol. 22, Issue 08, 086005, (August 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.8.086005

KEYWORDS: Backscatter, Reflectivity, Spatial frequencies, Tissues, Luminescence, Endomicroscopy, Mouth, Diagnostics, Tissue optics, Biopsy

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SPIE Journal Paper | 21 December 2016 Open Access

Fluorescence confocal endomicroscopy of the cervix: pilot study on the potential and limitations for clinical implementation

Colin Schlosser, Nico Bodenschatz, Sylvia Lam, Marette Lee, Jessica McAlpine, Dianne Miller, Dirk J. T. Van Niekerk, Michele Follen, Martial Guillaud, Calum MacAulay, Pierre Lane

JBO, Vol. 21, Issue 12, 126011, (December 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.12.126011

KEYWORDS: Tissues, Endomicroscopy, Luminescence, In vivo imaging, Cervix, Diagnostics, Confocal microscopy, Biopsy, Imaging systems, Optical fibers

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Proceedings Article | 23 March 2016 Paper

Automatic labeling of molecular biomarkers on a cell-by-cell basis in immunohistochemistry images using convolutional neural networks

Fahime Sheikhzadeh, Anita Carraro, Jagoda Korbelik, Calum MacAulay, Martial Guillaud, Rabab Ward

Proceedings Volume 9791, 97910R (2016) https://doi.org/10.1117/12.2217046

KEYWORDS: Convolutional neural networks, Neural networks, Tissues, Image analysis, Pathology, Cervical cancer, Clinical trials, Image classification, Computer aided diagnosis and therapy, Image segmentation, Convolution, Biopsy, Neurons, Image processing

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SPIE Journal Paper | 11 September 2015 Open Access

Geometrical and topological analysis of in vivo confocal microscopy images reveals dynamic maturation of epidermal structures during the first years of life

Jalil Bensaci, Zhao Yang Chen, M. Catherine Mack, Martial Guillaud, Georgios Stamatas

JBO, Vol. 20, Issue 09, 095004, (September 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.9.095004

KEYWORDS: Analytical research, Skin, Seaborgium, In vivo imaging, Confocal microscopy, Tissues, Image analysis, Statistical analysis, Cancer, Reflectivity

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Proceedings Article | 15 July 2015 Paper

Influence of structural length-scale variations on azimuth-resolved light scattering patterns of inhomogeneous cell models

Dizem Arifler, Martial Guillaud

Proceedings Volume 9537, 95370M (2015) https://doi.org/10.1117/12.2183690

KEYWORDS: Scattering, Light scattering, Tissue optics, Backscatter, Refractive index, Finite-difference time-domain method, Diagnostics, 3D modeling, Electromagnetic scattering, Imaging spectroscopy

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Proceedings Article | 27 April 2015 Paper

Confocal fluorescence microscopy for detection of cervical preneoplastic lesions

Fahime Sheikhzadeh, Rabab Ward, Anita Carraro, Zhaoyang Chen, Dirk van Niekerk, Calum MacAulay, Michele Follen, Pierre Lane, Martial Guillaud

Proceedings Volume 9420, 942009 (2015) https://doi.org/10.1117/12.2077268

KEYWORDS: Confocal microscopy, Tissues, Biopsy, Luminescence, Microscopy, Cancer, Cervical cancer, Image analysis, Cervix, Natural surfaces

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Proceedings Article | 4 March 2014 Paper

Diagnostic features in two-dimensional light scattering patterns of normal and dysplastic cervical cell nuclei

Dizem Arifler, Calum MacAulay, Michele Follen, Martial Guillaud

Proceedings Volume 8952, 89520W (2014) https://doi.org/10.1117/12.2041281

KEYWORDS: Light scattering, Scattering, Diagnostics, 3D modeling, Tumor growth modeling, Finite-difference time-domain method, Biopsy, Computer simulations, Data modeling, Cancer

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Proceedings Article | 3 March 2014 Paper

CI Slide: calibration slide for quantitative microscopy imaging in absorbance

Fahime Sheikhzadeh, Qian Ye, Nasir Zulkafly, Anita Carraro, Jagoda Korbelic, Zhaoyang Chen, Alan Harrison, Michele Follen, Calum MacAulay, Rabab Ward, Martial Guillaud

Proceedings Volume 8945, 894507 (2014) https://doi.org/10.1117/12.2041310

KEYWORDS: Scanners, Image segmentation, Imaging systems, Calibration, Error analysis, Cancer, Statistical analysis, Microscopy, Process control, Absorbance

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Proceedings Article | 18 June 2013 Paper

Numerical analysis of dysplasia-associated changes in depth-dependent light scattering profile of cervical epithelium

Dizem Arifler, Calum MacAulay, Michele Follen, Martial Guillaud

Proceedings Volume 8798, 879809 (2013) https://doi.org/10.1117/12.2031564

KEYWORDS: Scattering, Light scattering, Tumor growth modeling, Diagnostics, 3D modeling, Finite-difference time-domain method, Backscatter, Image segmentation, Biopsy, Numerical analysis

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SPIE Journal Paper | 7 August 2012 Open Access

High throughput image cytometry for detection of suspicious lesions in the oral cavity

Calum MacAulay, Catherine Poh, Martial Guillaud, Pamella Williams, Denise Laronde, Lewei Zhang, Miriam Rosin

JBO, Vol. 17, Issue 8, 086004, (August 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.8.086004

KEYWORDS: Cancer, Tissues, Statistical analysis, Visualization, Luminescence, Detection and tracking algorithms, Inflammation, Genetics, Cell biology, Biopsy

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SPIE Journal Paper | 1 March 2007 Open Access

Real-time reflectance confocal microscopy: comparison of two-dimensional images and three-dimensional image stacks for detection of cervical precancer

Thomas Collier, Martial Guillaud, Anais Malpica, Michelle Follen, Rebecca Richards-Kortum

JBO, Vol. 12, Issue 02, 024021, (March 2007) https://doi.org/10.1117/12.10.1117/1.2717899

KEYWORDS: Biopsy, 3D image processing, Confocal microscopy, Image segmentation, Tissues, Scattering, Reflectivity, 3D acquisition, Feature extraction, Image processing

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(Partial Abstract) Confocal microscopy can provide real-time, 2-D and 3-D images of the cellular morphology and tissue architecture features that pathologists use to detect precancerous lesions without the need for tissue removal, sectioning, and staining. The utility of 3-D confocal image stacks of epithelial tissue for detecting dysplasia has not yet been explored. We aim to extract morphometry and tissue architecture information from 2-D confocal reflectance images and 3-D image stacks from fresh, unstained cervical biopsies and compare their potential for detecting dysplasia. Nine biopsies are obtained from eight patients; confocal images are acquired pre- and postacetic acid at multiple epithelial depths in 1.5 µm-intervals. Postacetic acid images are processed to segment cell nuclei; after segmentation, 2-D images taken at 50 um below the tissue surface, and the entire 3-D image stacks are processed to extract morphological and architectural features. Data are analyzed to determine which features gave the best separation between normal and high-grade cervical precancer. Most significant differences are obtained from parameters extracted from the 3-D image stacks. However, in all cases where the 2-D features were multiplicatively scaled by the depth of acquisition divided by the epithelial thickness or scaled by the scattering coefficient, the significance level is equal to or greater than the comparable feature extracted from the 3-D image stacks. A linear discriminant function previously developed to separate 19 samples of normal tissue and high-grade cervical precancer based on the nuclear-to-cytoplasm (N/C) ratio and epithelial scattering coefficient is prospectively applied to the nine biopsies examined to determine the accuracy with which it could separate normal tissue from cervical intra epithelial neoplasia (CIN) 2/3. For the entire data set of 28 biopsies, a sensitivity and specificity of 100% is produced using this discriminant function;

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Proceedings Article | 19 February 2007 Paper

Hyperspectral imaging and spectral unmixing of stained tissue sections using a spectrally programmable light engine

N. MacKinnon, M. Khojasteh, P. Lane, C. MacAulay, M. Guillaud, U. Stange

Proceedings Volume 6441, 64410A (2007) https://doi.org/10.1117/12.702159

KEYWORDS: Tissues, Hyperspectral imaging, Tissue optics, Imaging systems, Control systems, RGB color model, Optical filters, Image segmentation, Image filtering, Lamps

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SPIE Journal Paper | 1 July 2003 Open Access

Light scattering from normal and dysplastic cervical cells at different epithelial depths: finite-difference time-domain modeling with a perfectly matched layer boundary condition

Dizem Arifler, Martial Guillaud, Anita Carraro, Anais Malpica, Michele Follen, Rebecca Richards-Kortum

JBO, Vol. 8, Issue 03, (July 2003) https://doi.org/10.1117/12.10.1117/1.1578640

KEYWORDS: Scattering, Light scattering, Finite-difference time-domain method, Refractive index, Mie scattering, Confocal microscopy, Cancer, Biopsy, Diagnostics, Dielectrics

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SPIE Journal Paper | 1 January 2003 Open Access

Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture

Rebekah Drezek, Martial Guillaud, Thomas Collier, Iouri Boiko, Anais Malpica, Calum MacAulay, Michele Follen, Rebecca Richards-Kortum

JBO, Vol. 8, Issue 01, (January 2003) https://doi.org/10.1117/12.10.1117/1.1528950

KEYWORDS: Scattering, Light scattering, Refractive index, Tissues, Finite-difference time-domain method, Data modeling, Reflectivity, Confocal microscopy, Tissue optics, Scatter measurement

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Proceedings Article | 27 April 2000 Paper

Quantitative architectural analysis of bronchial intraepithelial neoplasia

Martial Guillaud, Calum MacAulay, Jean Le Riche, Chris Dawe, Jagoda Korbelik, Stephen Lam

Proceedings Volume 3921, (2000) https://doi.org/10.1117/12.384231

KEYWORDS: Biopsy, Pathology, Tissues, Biological research, Cancer, Lung cancer, Statistical analysis, Lung, Feature extraction, Visualization

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Proceedings Article | 29 April 1998 Paper

Intermediate endpoint biomarkers for lung cancer chemoprevention

Calum MacAulay, Stephen Lam, Helga Klein-Parker, Adi Gazdar, Martial Guillaud, Peter Payne, Jean Le Riche, Chris Dawe, Pierre Band, Branko Palcic

Proceedings Volume 3260, (1998) https://doi.org/10.1117/12.307094

KEYWORDS: Biopsy, Lung cancer, Cancer, Tissues, Genetics, Luminescence, Visualization, Proteins, Cervical cancer, Endoscopy

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Showing 5 of 19 publications

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