We design an effective microsystem by integrating ultra thin Ag film patterned with two-dimensional nanodisk array with a microfluidic channel. The refractive index of liquid, which flowing through the channel, is determined by measuring the transmission spectra of this integrated microfluidic device. We systematically simulated the influence of structure parameters to refractive index sensitivity. By adjusting the structure parameters of two-dimensional nanodisk array, such as period, thickness and duty cycle, the sensitivity of refractive index can be improved. The results indicated that the refractive index sensitivity can reach up to 308 nm / refractive index unit (RIU) with proper design. By this way, we can achieve intuitive, convenient and non-polluted refractive index measurement.
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