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4 October 2022 Ultrasensitive plasmonic sensing of single biomolecular complexes (Conference Presentation)
Taka-aki Yano, Ryo Kato, Takuo Tanaka
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Proceedings Volume PC12203, Enhanced Spectroscopies and Nanoimaging 2022; PC1220306 (2022) https://doi.org/10.1117/12.2634885
Event: SPIE Nanoscience + Engineering, 2022, San Diego, California, United States
Abstract
Plasmon-enhanced biosensing has attracted considerable attention due to its capability of highly sensitive biomolecular detection and analysis. Here, we demonstrate several types of gap-mode plasmon-enhanced spectroscopies for detection of biomolecular complexes. The first one is demonstrated with a nanometric gap between a silver tip and gold substrate, enabling to detect gap-enhanced Raman scattering from an inorganic-binding peptide and to spectroscopically elucidate the binding dynamics and mechanism. The other demonstration is based on gap-mode SPR sensing of coronavirus (SARS-CoV-2) in which antibody-functionalized gold nanoparticle with relatively large diameter played crucial plasmonic roles in detecting SARS-CoV-2 nucleocapsid proteins at femtomolar lever.
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Taka-aki Yano, Ryo Kato, and Takuo Tanaka "Ultrasensitive plasmonic sensing of single biomolecular complexes (Conference Presentation)", Proc. SPIE PC12203, Enhanced Spectroscopies and Nanoimaging 2022, PC1220306 (4 October 2022); https://doi.org/10.1117/12.2634885
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KEYWORDS
Biosensing
Plasmonics
Gold
Spectroscopy
Biological research
Nanoparticles
Proteins
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