Structure-inherent targeting for biophotonic imaging and targeted therapy

Hak Soo Choi; Atsushi Yamashita; Seung Hun Park; Kai Bao; Homan Kang; Satoshi Kashiwagi; Wesley R. Stiles

doi:10.1117/12.2653853

17 March 2023 Structure-inherent targeting for biophotonic imaging and targeted therapy

Hak Soo Choi, Atsushi Yamashita, Seung Hun Park, Kai Bao, Homan Kang, Satoshi Kashiwagi, Wesley R. Stiles

Proceedings Volume PC12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX; PC123610E (2023) https://doi.org/10.1117/12.2653853
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

While ICG-based NIR imaging has shown great potential in intraoperative surgery, there are two fundamental and unsolved problems facing medical imaging: 1) nonspecific uptake of intravenously administered diagnostic and/or therapeutic agents by normal tissues and organs and 2) incomplete elimination of unbound targeted agents from the body. These problems make image-guided cancer surgery extremely difficult because the background signal is high, and therefore the TBR is low. Designing a targeted contrast agent that shows fast clearance from the background tissues and eventually from the body after complete targeting is the key to the success of image-guided interventions. “Structure-Inherent Targeting” is a strategy that combines tissue-specific targeting components and imaging domain into a single molecule for targeting and imaging specific tissues in real-time, where the compact structural design enables the unbound contrast agent to be easily cleared from the body after targeting.

Conference Presentation

Citation Download Citation

Hak Soo Choi, Atsushi Yamashita, Seung Hun Park, Kai Bao, Homan Kang, Satoshi Kashiwagi, and Wesley R. Stiles "Structure-inherent targeting for biophotonic imaging and targeted therapy", Proc. SPIE PC12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX, PC123610E (17 March 2023); https://doi.org/10.1117/12.2653853

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