A phosphorescent microneedle array for measurement of oxygen partial pressure in tissue

Matthias Müller; Juan Pedro Cascales Sandoval; Haley L. Marks; Michael Wang-Evers; Dieter Manstein; Conor L. Evans

doi:10.1117/12.2649485

6 March 2023 A phosphorescent microneedle array for measurement of oxygen partial pressure in tissue

Matthias Müller, Juan Pedro Cascales Sandoval, Haley L. Marks, Michael Wang-Evers, Dieter Manstein, Conor L. Evans

Proceedings Volume PC12375, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables IV; PC1237505 (2023) https://doi.org/10.1117/12.2649485
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

An oxygen-sensing microneedle array (MNA) was developed to monitor oxygen partial pressure in tissue in a minimally invasive fashion. The working principle is based on the quenching of emission intensity and phosphorescence lifetime of a Pt-core porphyrin embedded into the MNA. It was shown that the MNA is sufficiently robust to puncture human skin and to detect changes in oxygenation within the physiologically relevant range of 0-160 mmHg. Moreover, it was demonstrated that the MNA can be implemented into a wearable wireless optical readout system rendering the MNA a novel and user-friendly technique to monitor oxygen partial pressure in tissue.

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Citation Download Citation

Matthias Müller, Juan Pedro Cascales Sandoval, Haley L. Marks, Michael Wang-Evers, Dieter Manstein, and Conor L. Evans "A phosphorescent microneedle array for measurement of oxygen partial pressure in tissue", Proc. SPIE PC12375, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables IV, PC1237505 (6 March 2023); https://doi.org/10.1117/12.2649485

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KEYWORDS

Oxygen

Tissues

Skin

Blood

Phosphorescence

Electrodes

Heart

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