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15 March 2023 Multi-centimeter fascicle tracing in ex-vivo porcine vagus nerve using PS-OCT (Conference Presentation)
Yong-Chul Yoon, Ilyas Saytashev, Rex Chin-Hao Chen, Fernando P. S. Guastaldi, Abigail L. Gregg, Kip A. Luwdig, Daniel X. Hammer, Benjamin J. Vakoc
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Proceedings Volume PC12382, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2023; PC1238207 (2023) https://doi.org/10.1117/12.2657585
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Vagus nerve stimulation (VNS) yields promising therapeutic benefits but is often limited by off-target effects. Imaging tools that reveal the fascicular organization within the nerve can be used to better direct stimulation energy to the intended target. Here, we demonstrate polarization-sensitive (PS)-OCT imaging of an intact 7.5 cm ex-vivo porcine vagus nerve. The limited OCT penetration depth was overcome by using a dual-scanning microscope configured to simultaneously acquire B-scans from the upper and lower segments of a nerve sample. Three-dimensional maps of the complex fascicular organization in these nerves were generated.
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Yong-Chul Yoon, Ilyas Saytashev, Rex Chin-Hao Chen, Fernando P. S. Guastaldi, Abigail L. Gregg, Kip A. Luwdig, Daniel X. Hammer, and Benjamin J. Vakoc "Multi-centimeter fascicle tracing in ex-vivo porcine vagus nerve using PS-OCT (Conference Presentation)", Proc. SPIE PC12382, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2023, PC1238207 (15 March 2023); https://doi.org/10.1117/12.2657585
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KEYWORDS
Nerve
Image compression
Optical coherence tomography
Tissue optics
Image resolution
Microscopes
Modulation
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