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16 March 2023 Stand-off system for remote Raman detection of miRNA biomarkers using shifted excitation Raman difference spectroscopy (Conference Presentation)
Ren A. Odion, Vanessa Cupil-Garcia, Hsin-Neng Wang, Aidan Canning, Jianhong Hu, Martin Maiwald, Bernd Sumpf, Tai-Ping Sun, Tuan Vo-Dinh
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Proceedings Volume PC12396, Plasmonics in Biology and Medicine XX; PC1239601 (2023) https://doi.org/10.1117/12.2650554
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
MicroRNAs (miRNAs) have increasingly become an important biomarker target for applications ranging from clinical diagnostics to biofuel production monitoring. However, the current state of the art for the detection of such markers requires tedious processing and amplification techniques such as polymerase chain reaction (PCR). In an effort to create a relatively simple biosensing platform, we have developed a combined plasmonic biosensing method based on a Surface-Enhanced Raman Spectroscopy (SERS) platform called the inverse Molecular Sentinel (iMS) to directly detect in vivo miRNA such as miR858a. With Shifted Excitation Raman Difference Spectroscopy (SERDS), we can remotely detect these targets in the field in the presence of interfering background signal. The application of such technology can pave the way not just for biofuel monitoring but early and non-invasive disease detection and diagnostics.
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Ren A. Odion, Vanessa Cupil-Garcia, Hsin-Neng Wang, Aidan Canning, Jianhong Hu, Martin Maiwald, Bernd Sumpf, Tai-Ping Sun, and Tuan Vo-Dinh "Stand-off system for remote Raman detection of miRNA biomarkers using shifted excitation Raman difference spectroscopy (Conference Presentation)", Proc. SPIE PC12396, Plasmonics in Biology and Medicine XX, PC1239601 (16 March 2023); https://doi.org/10.1117/12.2650554
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KEYWORDS
Raman spectroscopy
Spectroscopy
Biofuels
Biosensing
Diagnostics
Surface enhanced Raman spectroscopy
Target detection
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