Proof-of-concept of fluorescence lifetime endoscopy using a novel nanosecond time-gated CAPS camera

Pooria Iranian; Thomas Lapauw; Thomas Van den Dries; Sevada Sahakian; Hans Ingelberts; Maarten Kuijk; Valery Ann Jacobs

doi:10.1117/12.3000945

19 March 2024 Proof-of-concept of fluorescence lifetime endoscopy using a novel nanosecond time-gated CAPS camera

Pooria Iranian, Thomas Lapauw, Thomas Van den Dries, Sevada Sahakian, Hans Ingelberts, Maarten Kuijk, Valery Ann Jacobs

Proceedings Volume PC12820, Endoscopic Microscopy XIX; PC1282002 (2024) https://doi.org/10.1117/12.3000945
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Fluorescence imaging has been widely used in fields like (pre)clinical imaging, as well as in other domains. With advancements in imaging technology and the development of new fluorescent labels, fluorescence lifetime imaging is gradually gaining recognition. Our research department is developing the CAPS camera, based on the Current-Assisted Photonic Sampler, to achieve real-time fluorescence lifetime imaging in the NIR (700-900nm) region. Incorporating fluorescence lifetime into endoscopy would further differentiate malignant and benign cells based on their distinct lifetimes. Therefore, the capabilities of the system are demonstrated using a rigid endoscope involving various phantoms and various lifetime processing approaches to get the uniform lifetime image because of the independence of fluorescence lifetime to the intensity when the intensity image is not.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Pooria Iranian, Thomas Lapauw, Thomas Van den Dries, Sevada Sahakian, Hans Ingelberts, Maarten Kuijk, and Valery Ann Jacobs "Proof-of-concept of fluorescence lifetime endoscopy using a novel nanosecond time-gated CAPS camera", Proc. SPIE PC12820, Endoscopic Microscopy XIX, PC1282002 (19 March 2024); https://doi.org/10.1117/12.3000945

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