Experimental comparison of parametric attenuation models in optical coherence tomography

Gavrielle R. Untracht; Morgane Zimmer; Lars Lindvold; Dominik Marti; Peter E. Andersen

doi:10.1117/12.3005423

13 March 2024 Experimental comparison of parametric attenuation models in optical coherence tomography

Gavrielle R. Untracht, Morgane Zimmer, Lars Lindvold, Dominik Marti, Peter E. Andersen

Proceedings Volume PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; PC128302R (2024) https://doi.org/10.1117/12.3005423
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Parametric imaging of attenuation using optical coherence tomography (OCT) is a powerful tool for assessing changes in tissue morphology associated with disease. Several models are available for extracting the optical properties of tissue from OCT images. However, the accuracy of these models and their dependence on the tissue optical properties has yet to be established. Here, we investigate the accuracy of several OCT models and assess their suitability for extracting optical properties. We establish that the single scattering models produce more precise results (lower variance), but the EHF model is more accurate. Furthermore, the accuracy of the single scattering model degrades as the scattering coefficient and thickness of the tissue increase. We intend that the results of this study will aid in the development of standardized protocols for extracting optical properties from OCT images.

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Gavrielle R. Untracht, Morgane Zimmer, Lars Lindvold, Dominik Marti, and Peter E. Andersen "Experimental comparison of parametric attenuation models in optical coherence tomography", Proc. SPIE PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, PC128302R (13 March 2024); https://doi.org/10.1117/12.3005423

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KEYWORDS

Optical coherence tomography

Attenuation

Scattering

Tissues

Optical properties

Absorption

Extremely high frequency

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