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The mid-infrared photothermal microscope enables super-resolution imaging of living systems in water. However, the slow tuning of the laser limits spectroscopic imaging output to one color per second. To solve this, we developed a microsecond-scale spectroscopic detection scheme with a fast-tuning quantum cascade laser array. Each laser in the array emits at a slightly different wavelength, operating independently. A sequential emission from 32 lasers is completed within 4 microseconds. The absorption spectrum is acquired by capturing the temperature rise curve and calculating the first derivative. This improved spectroscopic imaging covers 150 cm-1 wavenumbers at 5 cm-1 resolution in one second, enabling real-time multiplexed molecular analysis.
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Jiaze Yin, Cheyenne Teng, Christian Pfluegl, Ji-Xin Cheng, "Microsecond-scale mid-infrared energy deposition (MIRED) spectroscopic imaging," Proc. SPIE PC12855, Advanced Chemical Microscopy for Life Science and Translational Medicine 2024, PC128550L (13 March 2024); https://doi.org/10.1117/12.3003536